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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets

Gene Ranking Integration

Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets Datasets Gene Ranking

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Gene Page: TOB1

Summary

GeneID

10140

Symbol

TOB1

Synonyms

APRO6|MGC104792|MGC34446|PIG49|TOB|TROB|TROB1

Description

transducer of ERBB2, 1

Locus tag

Gene type

protein-coding

Map location

17q21

Gene in Data Sources

Gene set name

Method of gene set

Evidence

Info

Network

Shortest path distance of core genes in the Human protein-protein interaction network

Contribution to shortest path in PPI network: 0.0021

General Gene Expression (microarray) ?

Gene Expression in Brain Regions (new)

Top co-expressed genes in Brain Regions (new)

Gene

Pearson's Correlation

Spearman's Correlation

Top 10 positively co-expressed genes

MORF4L2

0.89

0.88

PPP2CA

0.88

0.85

DNAJA2

0.86

UBE2V2

0.86

0.87

AC018845.1

0.86

0.84

PPID

0.86

NDUFA5

0.86

0.89

TPM3

0.84

0.83

RAB2A

0.84

0.80

ZC3H15

0.83

0.86

Top 10 negatively co-expressed genes

MT-CO2

-0.62

-0.48

AF347015.2

-0.62

-0.47

HIGD1B

-0.60

-0.49

AF347015.26

-0.60

-0.45

MT-CYB

-0.59

-0.47

AF347015.9

-0.58

-0.50

AF347015.18

-0.57

-0.41

AF347015.33

-0.57

-0.46

AF347015.31

-0.57

-0.46

FXYD1

-0.56

-0.49

Gene Ontology

Molecular function

GO term

Evidence

Neuro keywords

PubMed ID

GO:0003714

transcription corepressor activity

IEA

GO:0005070

SH3/SH2 adaptor activity

TAS

8632892

GO:0046332

SMAD binding

IEA

Biological process

GO term

Evidence

Neuro keywords

PubMed ID

GO:0007184

SMAD protein nuclear translocation

IEA

GO:0008285

negative regulation of cell proliferation

TAS

8632892

GO:0030514

negative regulation of BMP signaling pathway

IEA

GO:0045668

negative regulation of osteoblast differentiation

IEA

Cellular component

GO term

Evidence

Neuro keywords

PubMed ID

GO:0005737

cytoplasm

IEA

Protein-protein Interactions

Shown by network

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
CNOT7	CAF1 \| hCAF-1	CCR4-NOT transcription complex, subunit 7	Affinity Capture-Western Reconstituted Complex	BioGRID	10602502 \|18056425
ERBB2	CD340 \| HER-2 \| HER-2/neu \| HER2 \| NEU \| NGL \| TKR1	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	-	HPRD	8632892
MAPK1	ERK \| ERK2 \| ERT1 \| MAPK2 \| P42MAPK \| PRKM1 \| PRKM2 \| p38 \| p40 \| p41 \| p41mapk	mitogen-activated protein kinase 1	-	HPRD,BioGRID	12151396
MAPK9	JNK-55 \| JNK2 \| JNK2A \| JNK2ALPHA \| JNK2B \| JNK2BETA \| PRKM9 \| SAPK \| p54a \| p54aSAPK	mitogen-activated protein kinase 9	Affinity Capture-Western Biochemical Activity Reconstituted Complex	BioGRID	12151396
MARCKS	80K-L \| FLJ14368 \| FLJ90045 \| MACS \| MRACKS \| PKCSL \| PRKCSL	myristoylated alanine-rich protein kinase C substrate	-	HPRD,BioGRID	11327693
PABPC1	PAB1 \| PABP \| PABP1 \| PABPC2 \| PABPL1	poly(A) binding protein, cytoplasmic 1	Affinity Capture-Western	BioGRID	18056425
SCMH1	Scml3	sex comb on midleg homolog 1 (Drosophila)	Two-hybrid	BioGRID	16169070
SETDB1	ESET \| KG1T \| KIAA0067 \| KMT1E	SET domain, bifurcated 1	Two-hybrid	BioGRID	16169070
SMAD1	BSP1 \| JV4-1 \| JV41 \| MADH1 \| MADR1	SMAD family member 1	-	HPRD,BioGRID	11163184
SMAD2	JV18 \| JV18-1 \| MADH2 \| MADR2 \| MGC22139 \| MGC34440 \| hMAD-2 \| hSMAD2	SMAD family member 2	-	HPRD	11163184
SMAD3	DKFZp586N0721 \| DKFZp686J10186 \| HSPC193 \| HsT17436 \| JV15-2 \| MADH3 \| MGC60396	SMAD family member 3	-	HPRD	11163184
SMAD4	DPC4 \| JIP \| MADH4	SMAD family member 4	-	HPRD,BioGRID	11163184
SMAD5	DKFZp781C1895 \| DKFZp781O1323 \| Dwfc \| JV5-1 \| MADH5	SMAD family member 5	-	HPRD,BioGRID	11163184
SMAD9	MADH6 \| MADH9 \| SMAD8A \| SMAD8B	SMAD family member 9	Affinity Capture-Western	BioGRID	11163184

miRNA Targets ?

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-129-5p	551	557	1A	hsa-miR-129^brain	CUUUUUGCGGUCUGGGCUUGC
miR-129-5p	551	557	1A	hsa-miR-129-5p	CUUUUUGCGGUCUGGGCUUGCU
miR-182	153	159	m8	hsa-miR-182	UUUGGCAAUGGUAGAACUCACA
miR-186	740	747	1A,m8	hsa-miR-186	CAAAGAAUUCUCCUUUUGGGCUU
miR-200bc/429	225	231	m8	hsa-miR-200b	UAAUACUGCCUGGUAAUGAUGAC
				hsa-miR-200c	UAAUACUGCCGGGUAAUGAUGG
				hsa-miR-429	UAAUACUGUCUGGUAAAACCGU
miR-218	162	169	1A,m8	hsa-miR-218^brain	UUGUGCUUGAUCUAACCAUGU
miR-25/32/92/363/367	645	652	1A,m8	hsa-miR-25^brain	CAUUGCACUUGUCUCGGUCUGA
				hsa-miR-32	UAUUGCACAUUACUAAGUUGC
				hsa-miR-92	UAUUGCACUUGUCCCGGCCUG
				hsa-miR-367	AAUUGCACUUUAGCAAUGGUGA
				hsa-miR-92b^SZ	UAUUGCACUCGUCCCGGCCUC
miR-26	651	658	1A,m8	hsa-miR-26a^brain	UUCAAGUAAUCCAGGAUAGGC
miR-26	651	658	1A,m8	hsa-miR-26b^SZ	UUCAAGUAAUUCAGGAUAGGUU
miR-30-3p	446	452	m8	hsa-miR-30a-3p	CUUUCAGUCGGAUGUUUGCAGC
				hsa-miR-30e-3p	CUUUCAGUCGGAUGUUUACAGC
				hsa-miR-30a-3p	CUUUCAGUCGGAUGUUUGCAGC
				hsa-miR-30e-3p	CUUUCAGUCGGAUGUUUACAGC
miR-381	309	315	1A	hsa-miR-381	UAUACAAGGGCAAGCUCUCUGU
miR-409-3p	102	108	1A	hsa-miR-409-3p	CGAAUGUUGCUCGGUGAACCCCU
miR-486	498	505	1A,m8	hsa-miR-486	UCCUGUACUGAGCUGCCCCGAG

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.