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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets

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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets Datasets Gene Ranking

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Gene Page: CDK2

Summary

GeneID

1017

Symbol

CDK2

Synonyms

p33(CDK2)

Description

cyclin-dependent kinase 2

Locus tag

Gene type

protein-coding

Map location

12q13

Gene in Data Sources

Gene set name

Method of gene set

Evidence

Info

GO_Annotation

Mapping neuro-related keywords to Gene Ontology annotations

Hits with neuro-related keywords: 2

Network

Shortest path distance of core genes in the Human protein-protein interaction network

Contribution to shortest path in PPI network: 0.0763

General Gene Expression (microarray) ?

Gene Expression in Brain Regions (new)

Top co-expressed genes in Brain Regions (new)

Gene

Pearson's Correlation

Spearman's Correlation

Top 10 positively co-expressed genes

EBNA1BP2

0.83

0.78

PSMC2

0.81

0.75

PSMD6

0.80

0.74

RG9MTD1

0.80

0.82

FKBP3

0.80

0.82

GGPS1

0.79

0.77

FARSB

0.79

0.72

EAPP

0.78

0.77

PSMA5

0.78

0.73

ORC4L

0.78

0.75

Top 10 negatively co-expressed genes

AF347015.2

-0.70

-0.50

AF347015.8

-0.67

-0.48

AF347015.26

-0.66

-0.49

AF347015.15

-0.66

-0.49

AF347015.18

-0.65

-0.45

AF347015.33

-0.65

-0.49

MT-CYB

-0.65

-0.48

MT-CO2

-0.64

-0.44

AF347015.31

-0.61

-0.46

AF347015.27

-0.60

-0.45

Gene Ontology

Molecular function

GO term

Evidence

Neuro keywords

PubMed ID

GO:0004693

cyclin-dependent protein kinase activity

EXP

neuron (GO term level: 8)

10548110

GO:0004693

cyclin-dependent protein kinase activity

TAS

neuron (GO term level: 8)

1653904

GO:0000166

nucleotide binding

IEA

GO:0005524

ATP binding

IEA

GO:0004674

protein serine/threonine kinase activity

IEA

GO:0016740

transferase activity

IEA

GO:0042802

identical protein binding

IPI

17353931

GO:0035173

histone kinase activity

IDA

8692841

Biological process

GO term

Evidence

Neuro keywords

PubMed ID

GO:0000086

G2/M transition of mitotic cell cycle

TAS

1653904

GO:0006468

protein amino acid phosphorylation

IEA

GO:0006275

regulation of DNA replication

TAS

9933170

GO:0007049

cell cycle

IEA

GO:0007067

mitosis

IEA

GO:0007089

traversing start control point of mitotic cell cycle

TAS

9933170

GO:0008284

positive regulation of cell proliferation

TAS

10767298

GO:0051301

cell division

IEA

Cellular component

GO term

Evidence

Neuro keywords

PubMed ID

GO:0000307

cyclin-dependent protein kinase holoenzyme complex

IDA

8692841

GO:0005829

cytosol

EXP

1312467 |7799941 |9840943
|11907280

GO:0005634

nucleus

IDA

16109376

GO:0005654

nucleoplasm

EXP

1396589 |7629134 |9840943
|10323868 |10339564
|10454565 |10548110
|11231585 |11340163
|11907280 |11931757
|1522

GO:0005737

cytoplasm

TAS

10767298

Protein-protein Interactions

Shown by network

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
BCCIP	TOK-1 \| TOK1	BRCA2 and CDKN1A interacting protein	Affinity Capture-Western	BioGRID	10878006
BCL2	Bcl-2	B-cell CLL/lymphoma 2	-	HPRD	15619620
BIRC5	API4 \| EPR-1	baculoviral IAP repeat-containing 5	Affinity Capture-Western	BioGRID	11069302
BRCA1	BRCAI \| BRCC1 \| IRIS \| PSCP \| RNF53	breast cancer 1, early onset	BRCA1 associates with CDK2	BIND	9244350 \|10373534
BRCA1	BRCAI \| BRCC1 \| IRIS \| PSCP \| RNF53	breast cancer 1, early onset	Affinity Capture-Western Reconstituted Complex	BioGRID	8764100 \|9244350 \|10373534
C12orf30	DKFZp667K2112 \| FLJ13089 \| MDM20	chromosome 12 open reading frame 30	Affinity Capture-MS	BioGRID	17353931
CABLES1	CABLES \| FLJ35924 \| HsT2563 \| IK3-1	Cdk5 and Abl enzyme substrate 1	-	HPRD	11585773
CASP4	ICE(rel)II \| ICEREL-II \| ICH-2 \| Mih1/TX \| TX	caspase 4, apoptosis-related cysteine peptidase	Affinity Capture-MS	BioGRID	17353931
CCNA1	-	cyclin A1	-	HPRD,BioGRID	9041194 \|10559988
CCNA1	-	cyclin A1	CCNA1 (CYCA) interacts with unspecified isoform of CDK2.	BIND	8463339
CCNA2	CCN1 \| CCNA	cyclin A2	Interaction between Cyclin A2 (PDB ID: 1JST_D) and CDK2 (PDB ID: 1JST_A).	BIND	8756328
			Interaction between CDK2 (PDB ID: 1JST_C) and Cyclin A2 (PDB ID: 1JST_B).	BIND	8756328
			Affinity Capture-Western	BioGRID	12853968
			Interaction between Cyclin A2 (PDB ID: 1JST_D) and CDK2 (PDB ID: 1JST_C).	BIND	8756328
			CDK2 interacts with CCNA2 (cyclin A) to form a complex.	BIND	8475101
			-	HPRD	10924145 \|11907280\|11907280
			CCNA2 (cyclin A) interacts with Cdk2.	BIND	8662825
			Cdk2 interacts with Cyc A.	BIND	15469821
			Cyclin A interacts with cdk2.	BIND	9632134
CCNB1	CCNB	cyclin B1	Affinity Capture-Western	BioGRID	9891079
CCNB3	-	cyclin B3	-	HPRD,BioGRID	12185076
CCNE1	CCNE	cyclin E1	-	HPRD,BioGRID	1388288
CCNE2	CYCE2	cyclin E2	-	HPRD,BioGRID	9858585
CCNE2	CYCE2	cyclin E2	-	HPRD	9858585 \|15232106
CDC25A	CDC25A2	cell division cycle 25 homolog A (S. pombe)	-	HPRD,BioGRID	8617791
CDC6	CDC18L \| HsCDC18 \| HsCDC6	cell division cycle 6 homolog (S. cerevisiae)	Affinity Capture-Western	BioGRID	9566895
CDK2AP1	DOC1 \| DORC1 \| ST19 \| doc-1 \| p12DOC-1	cyclin-dependent kinase 2 associated protein 1	-	HPRD,BioGRID	10938106
CDK6	MGC59692 \| PLSTIRE \| STQTL11	cyclin-dependent kinase 6	Co-purification	BioGRID	10934208
CDK7	CAK1 \| CDKN7 \| MO15 \| STK1 \| p39MO15	cyclin-dependent kinase 7	CDK7 phosphorylates an unspecified isoform of CDK2.	BIND	7629134
CDKN1A	CAP20 \| CDKN1 \| CIP1 \| MDA-6 \| P21 \| SDI1 \| WAF1 \| p21CIP1	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	p21WAF1 interacts with an unspecified isoform of Cdk2. This interaction was modelled on a demonstrated interaction between human p21WAF1 and Cdk2 from an unspecified species.	BIND	7780738
			p21 interacts with an unspecified isoform of Cdk2.	BIND	11302688
			p21 interacts with CDK2. This interaction was modeled on a demonstrated interaction between human p21 and hamster CDK2.	BIND	9467962
			p21 interacts with Cdk2.	BIND	9546435
			-	HPRD,BioGRID	12839982
CDKN1B	CDKN4 \| KIP1 \| MEN1B \| MEN4 \| P27KIP1	cyclin-dependent kinase inhibitor 1B (p27, Kip1)	p27 interacts with an unspecified isoform of CDK2.	BIND	15652749
			Cdk2 interacts with p27kip1.	BIND	15619620
			-	HPRD,BioGRID	12972555
			Cdk2 interacts with p27.	BIND	15469821
CDKN3	CDI1 \| CIP2 \| FLJ25787 \| KAP \| KAP1 \| MGC70625	cyclin-dependent kinase inhibitor 3	Affinity Capture-Western in vitro Two-hybrid	BioGRID	7569954 \|8127873 \|8242750 \|8242751 \|12745075
			-	HPRD	11463386 \|12745075
			-	HPRD	7569954 \|8242750 \|8242751
CEBPA	C/EBP-alpha \| CEBP	CCAAT/enhancer binding protein (C/EBP), alpha	-	HPRD,BioGRID	11684017
CHAF1B	CAF-1 \| CAF-IP60 \| CAF1 \| CAF1A \| CAF1P60 \| MPHOSPH7 \| MPP7	chromatin assembly factor 1, subunit B (p60)	-	HPRD	10938080
CKS1B	CKS1 \| PNAS-16 \| PNAS-18 \| ckshs1	CDC28 protein kinase regulatory subunit 1B	-	HPRD,BioGRID	8601310 \|12140288
CNOT7	CAF1 \| hCAF-1	CCR4-NOT transcription complex, subunit 7	-	HPRD,BioGRID	10602502
E2F1	E2F-1 \| RBAP1 \| RBBP3 \| RBP3	E2F transcription factor 1	-	HPRD,BioGRID	7969176
EPB41	4.1R \| EL1 \| HE	erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)	Affinity Capture-MS	BioGRID	17353931
FAM113A	C20orf81 \| DKFZp547L054 \| FLJ22376 \| bA12M19.1	family with sequence similarity 113, member A	Affinity Capture-MS	BioGRID	17353931
FBL	FIB \| FLRN \| RNU3IP1	fibrillarin	Affinity Capture-MS	BioGRID	17353931
FEN1	FEN-1 \| MF1 \| RAD2	flap structure-specific endonuclease 1	-	HPRD,BioGRID	12853968
HIST1H1B	H1 \| H1.5 \| H1F5 \| MGC126630 \| MGC126632	histone cluster 1, H1b	An unspecified isoform of CDK2 phosphorylates H1.	BIND	7629134
INCA1	HSD45 \| MGC148150 \| MGC148151	inhibitor of CDK interacting with cyclin A1	Biochemical Activity	BioGRID	15159402
LYN	FLJ26625 \| JTK8	v-yes-1 Yamaguchi sarcoma viral related oncogene homolog	-	HPRD,BioGRID	8806683 \|10432313
MCM3	HCC5 \| MGC1157 \| P1-MCM3 \| P1.h \| RLFB	minichromosome maintenance complex component 3	-	HPRD	15232106
MITF	MI \| WS2A \| bHLHe32	microphthalmia-associated transcription factor	MITF interacts with the CDK2 promoter.	BIND	15607961
MS4A3	CD20L \| HTM4	membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)	-	HPRD,BioGRID	11781350
MYBL2	B-MYB \| BMYB \| MGC15600	v-myb myeloblastosis viral oncogene homolog (avian)-like 2	Biochemical Activity	BioGRID	11264176
NEDD8	FLJ43224 \| MGC104393 \| MGC125896 \| MGC125897 \| Nedd-8	neural precursor cell expressed, developmentally down-regulated 8	Affinity Capture-MS	BioGRID	17353931
NPDC1	CAB \| CAB- \| CAB-1 \| CAB1 \| DKFZp586J0523	neural proliferation, differentiation and control, 1	-	HPRD,BioGRID	11042687
OGT	FLJ23071 \| HRNT1 \| MGC22921 \| O-GLCNAC	O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)	Affinity Capture-MS	BioGRID	17353931
ORC1L	HSORC1 \| ORC1 \| PARC1	origin recognition complex, subunit 1-like (yeast)	Affinity Capture-Western Biochemical Activity	BioGRID	11931757
ORC2L	ORC2	origin recognition complex, subunit 2-like (yeast)	-	HPRD	15232106
ORC2L	ORC2	origin recognition complex, subunit 2-like (yeast)	Biochemical Activity	BioGRID	11931757
PCNA	MGC8367	proliferating cell nuclear antigen	-	HPRD,BioGRID	10930425
PFTK2	ALS2CR7	PFTAIRE protein kinase 2	Affinity Capture-MS	BioGRID	17353931
POLA1	DKFZp686K1672 \| POLA \| p180	polymerase (DNA directed), alpha 1, catalytic subunit	Biochemical Activity	BioGRID	10877824
PPM1B	MGC21657 \| PP2C-beta-X \| PP2CB \| PP2CBETA \| PPC2BETAX	protein phosphatase 1B (formerly 2C), magnesium-dependent, beta isoform	Biochemical Activity Co-purification	BioGRID	10934208
PPP2CA	PP2Ac \| PP2CA \| RP-C	protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform	Biochemical Activity Co-purification	BioGRID	10934208
PRKCH	MGC26269 \| MGC5363 \| PKC-L \| PKCL \| PRKCL \| nPKC-eta	protein kinase C, eta	-	HPRD,BioGRID	11175348
PTMA	MGC104802 \| TMSA	prothymosin, alpha	-	HPRD	11310559
PTP4A3	PRL-3 \| PRL-R \| PRL3	protein tyrosine phosphatase type IVA, member 3	Affinity Capture-MS	BioGRID	17353931
RADIL	FLJ10324 \| KIAA1849 \| MGC161589	Rap GTPase interactor	Affinity Capture-MS	BioGRID	17353931
RB1	OSRC \| RB \| p105-Rb \| pRb \| pp110	retinoblastoma 1	CDK2 phosphorylates Rb carboxy-terminus.	BIND	15241418
RB1	OSRC \| RB \| p105-Rb \| pRb \| pp110	retinoblastoma 1	Biochemical Activity	BioGRID	10938106
RBL1	CP107 \| MGC40006 \| PRB1 \| p107	retinoblastoma-like 1 (p107)	Biochemical Activity in vitro in vivo	BioGRID	9891079 \|11884610
RBL1	CP107 \| MGC40006 \| PRB1 \| p107	retinoblastoma-like 1 (p107)	-	HPRD	8230483\|11884610
RBL2	FLJ26459 \| P130 \| Rb2	retinoblastoma-like 2 (p130)	-	HPRD,BioGRID	9188854
RBM4	DKFZp547K0918 \| LARK \| MGC75138 \| RBM4A \| ZCCHC21 \| ZCRB3A	RNA binding motif protein 4	Biochemical Activity	BioGRID	15159402
REL	C-Rel	v-rel reticuloendotheliosis viral oncogene homolog (avian)	Affinity Capture-Western	BioGRID	9731206
RRN3	DKFZp566E104 \| MGC104238 \| TIFIA	RRN3 RNA polymerase I transcription factor homolog (S. cerevisiae)	Reconstituted Complex	BioGRID	15004009
SKP2	FBL1 \| FBXL1 \| FLB1 \| MGC1366	S-phase kinase-associated protein 2 (p45)	Affinity Capture-Western Reconstituted Complex	BioGRID	10559858 \|15355997
SKP2	FBL1 \| FBXL1 \| FLB1 \| MGC1366	S-phase kinase-associated protein 2 (p45)	-	HPRD	10386600
SMAD2	JV18 \| JV18-1 \| MADH2 \| MADR2 \| MGC22139 \| MGC34440 \| hMAD-2 \| hSMAD2	SMAD family member 2	CDK2 phosphorylates Smad2. This interaction was modelled on a demonstrated interaction between Smad2 from an unspecified species and human CDK2.	BIND	15241418
SMAD3	DKFZp586N0721 \| DKFZp686J10186 \| HSPC193 \| HsT17436 \| JV15-2 \| MADH3 \| MGC60396	SMAD family member 3	CDK2 phosphorylates Smad3 on Thr8, Thr179, Ser204, Ser208 and Ser213. This interaction was modelled on a demonstrated interaction between Smad3 from an unspecified species and human CDK2.	BIND	15241418
SORT1	Gp95 \| NT3	sortilin 1	Affinity Capture-MS	BioGRID	17353931
SPDYA	MGC110856 \| MGC57218 \| Ringo3 \| SPDY1 \| SPY1	speedy homolog A (Drosophila)	-	HPRD	11980914 \|12839962
SPDYA	MGC110856 \| MGC57218 \| Ringo3 \| SPDY1 \| SPY1	speedy homolog A (Drosophila)	Affinity Capture-Western	BioGRID	12972555
TP53	FLJ92943 \| LFS1 \| TRP53 \| p53	tumor protein p53	Biochemical Activity	BioGRID	10884347
TSC22D1	DKFZp686O19206 \| MGC17597 \| RP11-269C23.2 \| TGFB1I4 \| TSC22	TSC22 domain family, member 1	Affinity Capture-MS	BioGRID	17353931
UBE2M	UBC-RS2 \| UBC12 \| hUbc12	ubiquitin-conjugating enzyme E2M (UBC12 homolog, yeast)	Affinity Capture-MS	BioGRID	17353931
UBTF	NOR-90 \| UBF	upstream binding transcription factor, RNA polymerase I	-	HPRD	11698641
UHRF2	DKFZp434B0920 \| DKFZp686G0837 \| MGC33463 \| NIRF \| RNF107 \| URF2	ubiquitin-like with PHD and ring finger domains 2	-	HPRD	15178429
VHL	HRCA1 \| RCA1 \| VHL1	von Hippel-Lindau tumor suppressor	Affinity Capture-MS	BioGRID	17353931
WDR8	FLJ20430 \| MGC99569	WD repeat domain 8	Affinity Capture-MS	BioGRID	17353931
XRCC6	CTC75 \| CTCBF \| G22P1 \| KU70 \| ML8 \| TLAA	X-ray repair complementing defective repair in Chinese hamster cells 6	Biochemical Activity	BioGRID	15159402

miRNA Targets ?

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-93.hd/291-3p/294/295/302/372/373/520	205	211	1A	hsa-miR-93^brain	AAAGUGCUGUUCGUGCAGGUAG
				hsa-miR-302a	UAAGUGCUUCCAUGUUUUGGUGA
				hsa-miR-302b	UAAGUGCUUCCAUGUUUUAGUAG
				hsa-miR-302c	UAAGUGCUUCCAUGUUUCAGUGG
				hsa-miR-302d	UAAGUGCUUCCAUGUUUGAGUGU
				hsa-miR-372	AAAGUGCUGCGACAUUUGAGCGU
				hsa-miR-373	GAAGUGCUUCGAUUUUGGGGUGU
				hsa-miR-520e	AAAGUGCUUCCUUUUUGAGGG
				hsa-miR-520a	AAAGUGCUUCCCUUUGGACUGU
				hsa-miR-520b	AAAGUGCUUCCUUUUAGAGGG
				hsa-miR-520c	AAAGUGCUUCCUUUUAGAGGGUU
				hsa-miR-520d	AAAGUGCUUCUCUUUGGUGGGUU

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.