Gene Page: RACK1
Summary ?
| GeneID | 10399 |
| Symbol | RACK1 |
| Synonyms | GNB2L1|Gnb2-rs1|H12.3|HLC-7|PIG21 |
| Description | receptor for activated C kinase 1 |
| Reference | MIM:176981|HGNC:HGNC:4399|Ensembl:ENSG00000204628|HPRD:01503|Vega:OTTHUMG00000163380 |
| Gene type | protein-coding |
| Map location | 5q35.3 |
| Support | Potential synaptic genes |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| PMID:cooccur | High-throughput literature-search | Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included. | |
| Literature | High-throughput literature-search | Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias | Click to show details |
Section I. Genetics and epigenetics annotation
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section III. Gene Ontology annotation
| Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0005102 | receptor binding | NAS | Neurotransmitter (GO term level: 4) | 12809483 |
| Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0043025 | cell soma | IEA | axon, dendrite (GO term level: 4) | - |
| GO:0005737 | cytoplasm | IEA | - |
Section IV. Protein-protein interaction annotation
| Interactors | Aliases B | Official full name B | Experimental | Source | PubMed ID |
|---|---|---|---|---|---|
| AGTRAP | ATRAP | MGC29646 | angiotensin II receptor-associated protein | - | HPRD,BioGRID | 11733189 |
| AR | AIS | DHTR | HUMARA | KD | NR3C4 | SBMA | SMAX1 | TFM | androgen receptor | - | HPRD,BioGRID | 12958311 |
| CCNA1 | - | cyclin A1 | Cyclin A1 interacts with RACK1. | BIND | 15159402 |
| CCNA1 | - | cyclin A1 | Reconstituted Complex Two-hybrid | BioGRID | 15159402 |
| CDKN1A | CAP20 | CDKN1 | CIP1 | MDA-6 | P21 | SDI1 | WAF1 | p21CIP1 | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | Two-hybrid | BioGRID | 16169070 |
| CSF2RB | CD131 | CDw131 | IL3RB | IL5RB | colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) | - | HPRD,BioGRID | 10490850 |
| DDX19B | DBP5 | DDX19 | RNAh | DEAD (Asp-Glu-Ala-As) box polypeptide 19B | Two-hybrid | BioGRID | 16169070 |
| DNM1 | DNM | dynamin 1 | - | HPRD | 12359736 |
| EIF6 | 2 | CAB | EIF3A | ITGB4BP | b | b(2)gcn | gcn | p27BBP | eukaryotic translation initiation factor 6 | - | HPRD,BioGRID | 14654845 |
| EIF6 | 2 | CAB | EIF3A | ITGB4BP | b | b(2)gcn | gcn | p27BBP | eukaryotic translation initiation factor 6 | eIF6 interacts with RACK1 | BIND | 14654845 |
| EPO | EP | MGC138142 | erythropoietin | - | HPRD | 12960323 |
| EPOR | MGC138358 | erythropoietin receptor | EPOR interacts with RACK-1. This interaction was modelled on a demonstrated interaction between EPOR from an unspecified species and human RACK-1. | BIND | 12960323 |
| EPOR | MGC138358 | erythropoietin receptor | - | HPRD,BioGRID | 12960323 |
| FYN | MGC45350 | SLK | SYN | FYN oncogene related to SRC, FGR, YES | - | HPRD,BioGRID | 11943848 |12524444 |
| GNB1 | - | guanine nucleotide binding protein (G protein), beta polypeptide 1 | - | HPRD | 12359736 |
| GOLM1 | C9orf155 | FLJ22634 | FLJ23608 | GOLPH2 | GP73 | PSEC0257 | bA379P1.3 | golgi membrane protein 1 | Two-hybrid | BioGRID | 16169070 |
| GRAP2 | GADS | GRAP-2 | GRB2L | GRBLG | GRID | GRPL | GrbX | Grf40 | Mona | P38 | GRB2-related adaptor protein 2 | GRAP2 (GRID) interacts with GNB2L1 (RACK-1). | BIND | 10820259 |
| GRAP2 | GADS | GRAP-2 | GRB2L | GRBLG | GRID | GRPL | GrbX | Grf40 | Mona | P38 | GRB2-related adaptor protein 2 | - | HPRD,BioGRID | 10820259 |
| GRIN2B | MGC142178 | MGC142180 | NMDAR2B | NR2B | hNR3 | glutamate receptor, ionotropic, N-methyl D-aspartate 2B | - | HPRD,BioGRID | 12524444 |
| HABP4 | IHABP4 | Ki-1/57 | MGC825 | SERBP1L | hyaluronan binding protein 4 | HABP4 (Ki-1/57) interacts with GNB2L1 (RACK1). | BIND | 14699138 |
| HABP4 | IHABP4 | Ki-1/57 | MGC825 | SERBP1L | hyaluronan binding protein 4 | - | HPRD,BioGRID | 14699138 |
| IFNAR2 | IFN-R | IFN-alpha-REC | IFNABR | IFNARB | interferon (alpha, beta and omega) receptor 2 | IFNR-beta-L interacts with RACK-1. | BIND | 12960323 |
| IFNAR2 | IFN-R | IFN-alpha-REC | IFNABR | IFNARB | interferon (alpha, beta and omega) receptor 2 | - | HPRD,BioGRID | 11046044 |
| IFNR | IFNGM | IFNGM2 | interferon production regulator | Reconstituted Complex | BioGRID | 12960323 |
| IGF1R | CD221 | IGFIR | JTK13 | MGC142170 | MGC142172 | MGC18216 | insulin-like growth factor 1 receptor | IGF-IR interacts with RACK1. | BIND | 11884618 |
| IGF1R | CD221 | IGFIR | JTK13 | MGC142170 | MGC142172 | MGC18216 | insulin-like growth factor 1 receptor | - | HPRD,BioGRID | 11884618 |
| IL2RB | CD122 | P70-75 | interleukin 2 receptor, beta | IL-2R-beta interacts with RACK-1. | BIND | 12960323 |
| IL2RB | CD122 | P70-75 | interleukin 2 receptor, beta | - | HPRD,BioGRID | 12960323 |
| IL4R | CD124 | IL4RA | interleukin 4 receptor | - | HPRD,BioGRID | 12960323 |
| IL4R | CD124 | IL4RA | interleukin 4 receptor | IL-4R-alpha interacts with RACK-1. This interaction was modelled on a demonstrated interaction between IL-4R-alpha from an unspecified species and human RACK-1. | BIND | 12960323 |
| ITGB1 | CD29 | FNRB | GPIIA | MDF2 | MSK12 | VLA-BETA | VLAB | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | beta-1 integrin interacts with RACK1. | BIND | 11884618 |
| ITGB1 | CD29 | FNRB | GPIIA | MDF2 | MSK12 | VLA-BETA | VLAB | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | - | HPRD,BioGRID | 9442085 |
| ITGB1 | CD29 | FNRB | GPIIA | MDF2 | MSK12 | VLA-BETA | VLAB | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | An unspecified isoform of integrin-beta-1 interacts with RACK1. | BIND | 15611085 |
| ITGB2 | CD18 | LAD | LCAMB | LFA-1 | MAC-1 | MF17 | MFI7 | integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) | - | HPRD,BioGRID | 9442085 |
| ITGB5 | FLJ26658 | integrin, beta 5 | - | HPRD | 9442085 |
| JAK1 | JAK1A | JAK1B | JTK3 | Janus kinase 1 (a protein tyrosine kinase) | RACK-1 interacts with Jak1. | BIND | 12960323 |
| JAK1 | JAK1A | JAK1B | JTK3 | Janus kinase 1 (a protein tyrosine kinase) | - | HPRD,BioGRID | 12960323 |
| LARP5 | DKFZp686M23113 | KIAA0217 | La ribonucleoprotein domain family, member 5 | Affinity Capture-MS | BioGRID | 12388589 |
| LRP12 | DKFZp781F1053 | FLJ12929 | ST7 | low density lipoprotein-related protein 12 | - | HPRD | 12809483 |
| NSMAF | FAN | neutral sphingomyelinase (N-SMase) activation associated factor | FAN interacts with RACK1. | BIND | 12391233 |
| NSMAF | FAN | neutral sphingomyelinase (N-SMase) activation associated factor | - | HPRD,BioGRID | 12391233 |
| PABPC1 | PAB1 | PABP | PABP1 | PABPC2 | PABPL1 | poly(A) binding protein, cytoplasmic 1 | - | HPRD,BioGRID | 12388589 |
| PDE4D | DPDE3 | HSPDE4D | PDE4DN2 | STRK1 | phosphodiesterase 4D, cAMP-specific (phosphodiesterase E3 dunce homolog, Drosophila) | - | HPRD,BioGRID | 10329691 |
| PDE4D | DPDE3 | HSPDE4D | PDE4DN2 | STRK1 | phosphodiesterase 4D, cAMP-specific (phosphodiesterase E3 dunce homolog, Drosophila) | RACK1 interacts with PDE4D5. | BIND | 10329691 |11516626 |12193273 |
| PLCG1 | PLC-II | PLC1 | PLC148 | PLCgamma1 | phospholipase C, gamma 1 | - | HPRD,BioGRID | 8290562 |
| PRKCA | AAG6 | MGC129900 | MGC129901 | PKC-alpha | PKCA | PRKACA | protein kinase C, alpha | Affinity Capture-Western | BioGRID | 12435334 |
| PRKCB | MGC41878 | PKC-beta | PKCB | PRKCB1 | PRKCB2 | protein kinase C, beta | Affinity Capture-Western Reconstituted Complex | BioGRID | 10480917 |
| PRKCD | MAY1 | MGC49908 | PKCD | nPKC-delta | protein kinase C, delta | PKC-delta interacts with RACK1. | BIND | 11884618 |
| PRKCE | MGC125656 | MGC125657 | PKCE | nPKC-epsilon | protein kinase C, epsilon | Affinity Capture-Western Far Western Reconstituted Complex | BioGRID | 11956211 |
| PRKD1 | PKC-MU | PKCM | PKD | PRKCM | protein kinase D1 | PKC-mu interacts with RACK1. | BIND | 11884618 |
| PTN | HARP | HBGF8 | HBNF | NEGF1 | pleiotrophin | Two-hybrid | BioGRID | 16169070 |
| PTPRM | MGC166994 | PTPRL1 | R-PTP-MU | RPTPM | RPTPU | hR-PTPu | protein tyrosine phosphatase, receptor type, M | Affinity Capture-Western Two-hybrid | BioGRID | 11278757 |11801604 |
| RASA1 | CM-AVM | CMAVM | DKFZp434N071 | GAP | PKWS | RASA | RASGAP | p120GAP | p120RASGAP | RAS p21 protein activator (GTPase activating protein) 1 | RACK1 interacts with p120GAP.This interaction was modeled on a demonstrated interaction between RACK1 from mouse and rat, and human p120GAP. | BIND | 11350068 |
| RASA1 | CM-AVM | CMAVM | DKFZp434N071 | GAP | PKWS | RASA | RASGAP | p120GAP | p120RASGAP | RAS p21 protein activator (GTPase activating protein) 1 | - | HPRD,BioGRID | 11350068 |
| RASA3 | GAP1IP4BP | GAPIII | MGC46517 | MGC47588 | RAS p21 protein activator 3 | - | HPRD,BioGRID | 11350068 |
| RB1 | OSRC | RB | p105-Rb | pRb | pp110 | retinoblastoma 1 | - | HPRD,BioGRID | 12761493 |
| RB1 | OSRC | RB | p105-Rb | pRb | pp110 | retinoblastoma 1 | RACK1 interacts with Rb | BIND | 12761493 |
| SFRS12 | DKFZp564B176 | MGC133045 | SRrp508 | SRrp86 | splicing factor, arginine/serine-rich 12 | - | HPRD | 14559993 |
| SLC27A6 | ACSVL2 | DKFZp779M0564 | FACVL2 | FATP6 | VLCS-H1 | solute carrier family 27 (fatty acid transporter), member 6 | Two-hybrid | BioGRID | 16169070 |
| SLC6A3 | DAT | DAT1 | solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 | DAT interacts with RACK1. | BIND | 15202772 |
| SLC9A3R1 | EBP50 | NHERF | NHERF1 | NPHLOP2 | solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1 | Affinity Capture-Western | BioGRID | 11956211 |
| SRC | ASV | SRC1 | c-SRC | p60-Src | v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) | - | HPRD,BioGRID | 9584165 |
| ST7 | DKFZp762O2113 | ETS7q | FAM4A | FAM4A1 | HELG | RAY1 | SEN4 | TSG7 | suppression of tumorigenicity 7 | Affinity Capture-Western Two-hybrid | BioGRID | 12809483 |
| STAT1 | DKFZp686B04100 | ISGF-3 | STAT91 | signal transducer and activator of transcription 1, 91kDa | - | HPRD,BioGRID | 11301323 |
| STAT1 | DKFZp686B04100 | ISGF-3 | STAT91 | signal transducer and activator of transcription 1, 91kDa | RACK-1 interacts with STAT1-beta. | BIND | 12960323 |
| STAT1 | DKFZp686B04100 | ISGF-3 | STAT91 | signal transducer and activator of transcription 1, 91kDa | RACK-1 interacts with STAT1-alpha. | BIND | 12960323 |
| TNFRSF1A | CD120a | FPF | MGC19588 | TBP1 | TNF-R | TNF-R-I | TNF-R55 | TNFAR | TNFR1 | TNFR55 | TNFR60 | p55 | p55-R | p60 | tumor necrosis factor receptor superfamily, member 1A | TNF-R55 interacts with RACK1. | BIND | 12391233 |
| TNFRSF1A | CD120a | FPF | MGC19588 | TBP1 | TNF-R | TNF-R-I | TNF-R55 | TNFAR | TNFR1 | TNFR55 | TNFR60 | p55 | p55-R | p60 | tumor necrosis factor receptor superfamily, member 1A | - | HPRD | 12391233 |
| TP63 | AIS | B(p51A) | B(p51B) | EEC3 | KET | LMS | NBP | OFC8 | RHS | SHFM4 | TP53CP | TP53L | TP73L | p40 | p51 | p53CP | p63 | p73H | p73L | tumor protein p63 | Two-hybrid | BioGRID | 12692135 |
| TP73 | P73 | tumor protein p73 | RACK1 interacts with p73. | BIND | 12761493 |
| TP73 | P73 | tumor protein p73 | - | HPRD,BioGRID | 12761493 |
| TSC22D4 | THG-1 | THG1 | TSC22 domain family, member 4 | Two-hybrid | BioGRID | 16189514 |
| TUBB2A | TUBB | TUBB2 | dJ40E16.7 | tubulin, beta 2A | - | HPRD | 12884273 |
| TYK2 | JTK1 | tyrosine kinase 2 | RACK-1 interacts with Tyk2. | BIND | 12960323 |
| TYK2 | JTK1 | tyrosine kinase 2 | Affinity Capture-Western Reconstituted Complex | BioGRID | 12960323 |