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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets

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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets Datasets Gene Ranking

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Gene Page: NCOA2

Summary

GeneID

10499

Symbol

NCOA2

Synonyms

GRIP1|KAT13C|MGC138808|NCoA-2|TIF2

Description

nuclear receptor coactivator 2

See related

HGNC:7669|MIM:601993|HPRD:09066|

Locus tag

Gene type

protein-coding

Map location

8q13.3

Gene in Data Sources

Gene set name

Method of gene set

Evidence

Info

GO_Annotation

Mapping neuro-related keywords to Gene Ontology annotations

Hits with neuro-related keywords: 1

General Gene Expression (microarray) ?

Gene Expression in Brain Regions (new)

Top co-expressed genes in Brain Regions (new)

Gene

Pearson's Correlation

Spearman's Correlation

Top 10 positively co-expressed genes

Top 10 negatively co-expressed genes

Gene Ontology

Molecular function

GO term

Evidence

Neuro keywords

PubMed ID

GO:0005102

receptor binding

IEA

Neurotransmitter (GO term level: 4)

GO:0004871

signal transducer activity

IEA

GO:0003713

transcription coactivator activity

NAS

9430642

GO:0005509

calcium ion binding

IEA

GO:0016564

transcription repressor activity

IEA

GO:0035257

nuclear hormone receptor binding

IEA

GO:0030375

thyroid hormone receptor coactivator activity

IEA

Biological process

GO term

Evidence

Neuro keywords

PubMed ID

GO:0000122

negative regulation of transcription from RNA polymerase II promoter

IEA

GO:0006355

regulation of transcription, DNA-dependent

NAS

8670870

GO:0007165

signal transduction

IEA

GO:0030518

steroid hormone receptor signaling pathway

IEA

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

IEA

Cellular component

GO term

Evidence

Neuro keywords

PubMed ID

GO:0005634

nucleus

NAS

GO:0005737

cytoplasm

IEA

Protein-protein Interactions

Shown by network

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
AHR	-	aryl hydrocarbon receptor	Affinity Capture-Western	BioGRID	12024042
AHR	-	aryl hydrocarbon receptor	AHR interacts with NCOA2 (TIF2).	BIND	15641800
ANKRD11	ANCO-1 \| LZ16 \| T13	ankyrin repeat domain 11	ANCO-1 interacts with TIF2. This interaction was modeled on a demonstrated interaction between human ANCO-1 and TIF2 from an unspecified species.	BIND	15184363
ANKRD11	ANCO-1 \| LZ16 \| T13	ankyrin repeat domain 11	-	HPRD,BioGRID	15184363
AR	AIS \| DHTR \| HUMARA \| KD \| NR3C4 \| SBMA \| SMAX1 \| TFM	androgen receptor	Affinity Capture-Western Protein-peptide Reconstituted Complex Two-hybrid	BioGRID	12612084 \|12810069 \|14593076 \|14966121
			GRIP1 interacts with AR. This interaction was modeled on a demonstrated interaction between mouse GRIP1 and human AR.	BIND	10454563
			-	HPRD	9717843
			-	HPRD	9717843 \|12588987
ARNT	HIF-1beta \| HIF1B \| HIF1BETA \| TANGO \| bHLHe2	aryl hydrocarbon receptor nuclear translocator	-	HPRD,BioGRID	12024042
BRCA1	BRCAI \| BRCC1 \| IRIS \| PSCP \| RNF53	breast cancer 1, early onset	Protein-peptide Reconstituted Complex	BioGRID	11085509 \|14578343
CCNT1	CCNT \| CYCT1	cyclin T1	Cyclin T1 interacts with GRIP1.	BIND	11704662
EP300	KAT3B \| p300	E1A binding protein p300	GRIP1 interacts with p300. This interaction was modeled on a demonstrated interaction between mouse GRIP1 and human p300.	BIND	9920895
ESR1	DKFZp686N23123 \| ER \| ESR \| ESRA \| Era \| NR3A1	estrogen receptor 1	ER alpha interacts with TIF2. This interaction was modeled on a demonstrated interaction between TIF2 from an unspecified source and human ER alpha.	BIND	10706629
ESR1	DKFZp686N23123 \| ER \| ESR \| ESRA \| Era \| NR3A1	estrogen receptor 1	-	HPRD,BioGRID	11937504
ESRRB	DFNB35 \| ERR2 \| ERRb \| ERRbeta \| ERRbeta-2 \| ESRL2 \| NR3B2	estrogen-related receptor beta	Reconstituted Complex	BioGRID	10598588
GMEB1	P96PIF \| PIF96	glucocorticoid modulatory element binding protein 1	-	HPRD	10692587
HNF4A	FLJ39654 \| HNF4 \| HNF4a7 \| HNF4a8 \| HNF4a9 \| MODY \| MODY1 \| NR2A1 \| NR2A21 \| TCF \| TCF14	hepatocyte nuclear factor 4, alpha	-	HPRD,BioGRID	9812974
MAGEA11	MAGE-11 \| MAGE11 \| MAGEA-11 \| MGC10511	melanoma antigen family A, 11	Affinity Capture-Western	BioGRID	15684378
NCOA1	F-SRC-1 \| KAT13A \| MGC129719 \| MGC129720 \| NCoA-1 \| RIP160 \| SRC-1 \| SRC1 \| bHLHe42	nuclear receptor coactivator 1	Affinity Capture-MS in vitro	BioGRID	11514567 \|11971985
NCOA3	ACTR \| AIB-1 \| AIB1 \| CAGH16 \| CTG26 \| KAT13B \| MGC141848 \| RAC3 \| SRC3 \| TNRC14 \| TNRC16 \| TRAM-1 \| pCIP	nuclear receptor coactivator 3	Affinity Capture-MS	BioGRID	11971985
NKX2-1	BCH \| BHC \| NK-2 \| NKX2.1 \| NKX2A \| TEBP \| TITF1 \| TTF-1 \| TTF1	NK2 homeobox 1	Two-hybrid	BioGRID	10617585
NR3C1	GCCR \| GCR \| GR \| GRL	nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)	-	HPRD,BioGRID	12151000
NR3C1	GCCR \| GCR \| GR \| GRL		GR-alpha interacts with GRIP1.	BIND	11704662
PPARG	NR1C3 \| PPARG1 \| PPARG2 \| PPARgamma	peroxisome proliferator-activated receptor gamma	-	HPRD,BioGRID	10944516
PPFIA1	FLJ41337 \| FLJ42630 \| FLJ43474 \| LIP.1 \| LIP1 \| LIPRIN \| MGC26800	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1	-	HPRD,BioGRID	11931740
PPFIA4	-	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4	Reconstituted Complex Two-hybrid	BioGRID	11931740
PRMT1	ANM1 \| HCP1 \| HRMT1L2 \| IR1B4	protein arginine methyltransferase 1	-	HPRD,BioGRID	11050077
RARA	NR1B1 \| RAR	retinoic acid receptor, alpha	GRIP1 interacts with RAR. This interaction was modeled on a demonstrated interaction between mouse GRIP1 and human RAR.	BIND	9920895
RORA	DKFZp686M2414 \| MGC119326 \| MGC119329 \| NR1F1 \| ROR1 \| ROR2 \| ROR3 \| RZR-ALPHA \| RZRA	RAR-related orphan receptor A	-	HPRD	10478845
RXRA	FLJ00280 \| FLJ00318 \| FLJ16020 \| FLJ16733 \| MGC102720 \| NR2B1	retinoid X receptor, alpha	GRIP1 interacts with RXR. This interaction was modeled on a demonstrated interaction between mouse GRIP1 and human RXR.	BIND	9920895
RXRA		retinoid X receptor, alpha	Reconstituted Complex Two-hybrid	BioGRID	11851396 \|12612084
SRCAP	DOMO1 \| EAF1 \| FLJ44499 \| KIAA0309 \| SWR1	Snf2-related CREBBP activator protein	-	HPRD	14500758
THRB	ERBA-BETA \| ERBA2 \| GRTH \| MGC126109 \| MGC126110 \| NR1A2 \| PRTH \| THR1 \| THRB1 \| THRB2	thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian)	-	HPRD,BioGRID	11518802
THRB			GRIP1 interacts with TR. This interaction was modeled on a demonstrated interaction between mouse GRIP1 and human TR.	BIND	10454563
VDR	NR1I1	vitamin D (1,25- dihydroxyvitamin D3) receptor	Affinity Capture-Western Reconstituted Complex Two-hybrid	BioGRID	10748178 \|12612084 \|12837248
VDR	NR1I1	vitamin D (1,25- dihydroxyvitamin D3) receptor	GRIP1 interacts with VDR. This interaction was modeled on a demonstrated interaction between mouse GRIP1 and human VDR.	BIND	9920895
YWHAH	YWHA1	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide	-	HPRD	11266503

miRNA Targets ?

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-137	1244	1251	1A,m8	hsa-miR-137	UAUUGCUUAAGAAUACGCGUAG
miR-181	313	320	1A,m8	hsa-miR-181a^brain	AACAUUCAACGCUGUCGGUGAGU
				hsa-miR-181b^SZ	AACAUUCAUUGCUGUCGGUGGG
				hsa-miR-181c^brain	AACAUUCAACCUGUCGGUGAGU
				hsa-miR-181d^brain	AACAUUCAUUGUUGUCGGUGGGUU
miR-186	1535	1541	m8	hsa-miR-186	CAAAGAAUUCUCCUUUUGGGCUU
miR-199	379	385	m8	hsa-miR-199a	CCCAGUGUUCAGACUACCUGUUC
miR-199	379	385	m8	hsa-miR-199b	CCCAGUGUUUAGACUAUCUGUUC
miR-200bc/429	1337	1344	1A,m8	hsa-miR-200b	UAAUACUGCCUGGUAAUGAUGAC
				hsa-miR-200c	UAAUACUGCCGGGUAAUGAUGG
				hsa-miR-429	UAAUACUGUCUGGUAAAACCGU
miR-330	391	397	m8	hsa-miR-330^brain	GCAAAGCACACGGCCUGCAGAGA
miR-448	1489	1495	m8	hsa-miR-448	UUGCAUAUGUAGGAUGUCCCAU

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.