Gene Page: SH2B2

Summary
GeneID  10603
Symbol  SH2B2
Synonyms  APS
Description  SH2B adaptor protein 2
See related  HGNC:17381|MIM:605300|HPRD:16097|
Locus tag  -
Gene type  protein-coding
Map location  7q22
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0474 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005070SH3/SH2 adaptor activityIDA9233773 
GO:0005515protein bindingIEA-
GO:0008269JAK pathway signal transduction adaptor activityIDA10374881 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007242intracellular signaling cascadeIDA9233773 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005737cytoplasmIDA9989826 
GO:0005886plasma membraneIDA9989826 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
BTKAGMX1 | AT | ATK | BPK | IMD1 | MGC126261 | MGC126262 | PSCTK1 | XLABruton agammaglobulinemia tyrosine kinase-HPRD10872802 
CBLC-CBL | CBL2 | RNF55Cas-Br-M (murine) ecotropic retroviral transforming sequenceReconstituted ComplexBioGRID10374881 
FYNMGC45350 | SLK | SYNFYN oncogene related to SRC, FGR, YES-HPRD10872802 
GRB2ASH | EGFRBP-GRB2 | Grb3-3 | MST084 | MSTP084growth factor receptor-bound protein 2Affinity Capture-WesternBioGRID9856458 
INSRCD220 | HHF5insulin receptor-HPRD10196204 
JAK2JTK10Janus kinase 2 (a protein tyrosine kinase)Biochemical ActivityBioGRID10374881 
-HPRD10872802 
JAK3JAK-3 | JAK3_HUMAN | JAKL | L-JAK | LJAKJanus kinase 3 (a protein tyrosine kinase, leukocyte)-HPRD10872802 
KITC-Kit | CD117 | PBT | SCFRv-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog-HPRD10872802 
LYNFLJ26625 | JTK8v-yes-1 Yamaguchi sarcoma viral related oncogene homolog-HPRD10872802 
NTRK1DKFZp781I14186 | MTC | TRK | TRK1 | TRKA | p140-TrkAneurotrophic tyrosine kinase, receptor, type 1Affinity Capture-Western
Two-hybrid		BioGRID9856458 
SYKDKFZp313N1010 | FLJ25043 | FLJ37489spleen tyrosine kinase-HPRD10872802 
 


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