Gene Page: NEK6

Summary
GeneID  10783
Symbol  NEK6
Synonyms  SID6-1512
Description  NIMA (never in mitosis gene a)-related kinase 6
See related  HGNC:7749|MIM:604884|Ensembl:ENSG00000119408|HPRD:05348|
Locus tag  RP11-101K10.6
Gene type  protein-coding
Map location  9q33.3-q34.11
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0531 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0000287magnesium ion bindingIDA14563848 
GO:0004871signal transducer activityIMP12761501 
GO:0005515protein bindingIPI16476580 |17353931 
GO:0005524ATP bindingIDA14563848 
GO:0004674protein serine/threonine kinase activityIDA14563848 
GO:0016740transferase activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006468protein amino acid phosphorylationIDA14563848 
GO:0007049cell cycleIEA-
GO:0007067mitosisIEA-
GO:0006915apoptosisIEA-
GO:0007059chromosome segregationIDA14563848 
GO:0051301cell divisionIEA-
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB cascadeIMP12761501 
GO:0030071regulation of mitotic metaphase/anaphase transitionIDA14563848 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusIDA12054534 
GO:0005737cytoplasmIDA12054534 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CCDC85BDIPAcoiled-coil domain containing 85BTwo-hybridBioGRID16189514 
CDC37P50CDC37cell division cycle 37 homolog (S. cerevisiae)Affinity Capture-MSBioGRID17353931 
DYNLL1DLC1 | DLC8 | DNCL1 | DNCLC1 | LC8 | LC8a | MGC126137 | MGC126138 | PIN | hdlc1dynein, light chain, LC8-type 1Affinity Capture-MSBioGRID17353931 
EML2ELP70 | EMAP-2 | EMAP2echinoderm microtubule associated protein like 2Affinity Capture-MSBioGRID17353931 
EML3ELP95 | FLJ35827 | MGC111422echinoderm microtubule associated protein like 3Affinity Capture-MSBioGRID17353931 
EML4C2orf2 | DKFZp686P18118 | ELP120 | FLJ10942 | FLJ32318 | ROPP120echinoderm microtubule associated protein like 4Affinity Capture-MSBioGRID17353931 
FANCIFLJ10719 | KIAA1794Fanconi anemia, complementation group IAffinity Capture-MSBioGRID17353931 
GCN1L1GCN1 | GCN1L | KIAA0219GCN1 general control of amino-acid synthesis 1-like 1 (yeast)Affinity Capture-MSBioGRID17353931 
IPO4FLJ23338 | Imp4 | MGC131665importin 4Affinity Capture-MSBioGRID17353931 
KDELR1ERD2 | ERD2.1 | HDEL | PM23KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1Affinity Capture-MSBioGRID17353931 
KIAA1967DBC-1 | DBC1KIAA1967Affinity Capture-MSBioGRID17353931 
LRPPRCCLONE-23970 | GP130 | LRP130 | LSFCleucine-rich PPR-motif containingAffinity Capture-MSBioGRID17353931 
MCM7CDABP0042 | CDC47 | MCM2 | P1.1-MCM3 | P1CDC47 | P85MCM | PNAS-146minichromosome maintenance complex component 7Affinity Capture-MSBioGRID17353931 
MYO1CFLJ23903 | MMI-beta | MMIb | NMI | myr2myosin ICAffinity Capture-MSBioGRID17353931 
NECAB2EFCBP2N-terminal EF-hand calcium binding protein 2Two-hybridBioGRID16189514 
NEK7-NIMA (never in mitosis gene a)-related kinase 7Affinity Capture-MSBioGRID17353931 
NEK9DKFZp434D0935 | MGC138306 | MGC16714 | NERCC | NERCC1 | Nek8NIMA (never in mitosis gene a)- related kinase 9-HPRD,BioGRID12101123 |12840024 
NUP93KIAA0095 | MGC21106nucleoporin 93kDaAffinity Capture-MSBioGRID17353931 
PCID2DKFZp686C20226 | F10 | FLJ11305 | FLJ99362 | MGC16774PCI domain containing 2Affinity Capture-MSBioGRID17353931 
PSMD2MGC14274 | P97 | Rpn1 | S2 | TRAP2proteasome (prosome, macropain) 26S subunit, non-ATPase, 2Affinity Capture-MSBioGRID17353931 
PTPLAD1B-IND1 | FLJ90376 | HSPC121protein tyrosine phosphatase-like A domain containing 1Affinity Capture-MSBioGRID17353931 
RUVBL2CGI-46 | ECP51 | INO80J | REPTIN | RVB2 | TIH2 | TIP48 | TIP49BRuvB-like 2 (E. coli)Affinity Capture-MSBioGRID17353931 
SLC1A5AAAT | ASCT2 | ATBO | FLJ31068 | M7V1 | M7VS1 | R16 | RDRCsolute carrier family 1 (neutral amino acid transporter), member 5Affinity Capture-MSBioGRID17353931 
SMC3BAM | BMH | CDLS3 | CSPG6 | HCAP | SMC3L1structural maintenance of chromosomes 3Affinity Capture-MSBioGRID17353931 
USP9XDFFRX | FAF | FAMubiquitin specific peptidase 9, X-linkedAffinity Capture-MSBioGRID17353931 
XPO5FLJ14239 | FLJ32057 | FLJ45606 | KIAA1291exportin 5Affinity Capture-MSBioGRID17353931 
 
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-128110311091Ahsa-miR-128aUCACAGUGAACCGGUCUCUUUU
hsa-miR-128bUCACAGUGAACCGGUCUCUUUC
miR-219234240m8hsa-miR-219brainUGAUUGUCCAAACGCAAUUCU
miR-233043111A,m8hsa-miR-23abrainAUCACAUUGCCAGGGAUUUCC
hsa-miR-23bbrainAUCACAUUGCCAGGGAUUACC
hsa-miR-23abrainAUCACAUUGCCAGGGAUUUCC
hsa-miR-23bbrainAUCACAUUGCCAGGGAUUACC
miR-264551m8hsa-miR-26abrainUUCAAGUAAUCCAGGAUAGGC
hsa-miR-26bSZUUCAAGUAAUUCAGGAUAGGUU
miR-27110311101A,m8hsa-miR-27abrainUUCACAGUGGCUAAGUUCCGC
hsa-miR-27bbrainUUCACAGUGGCUAAGUUCUGC
miR-323112311291Ahsa-miR-323brainGCACAUUACACGGUCGACCUCU
hsa-miR-323brainGCACAUUACACGGUCGACCUCU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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