Gene Page: FRS2

Summary
GeneID  10818
Symbol  FRS2
Synonyms  FRS2A|FRS2alpha|SNT|SNT-1|SNT1
Description  fibroblast growth factor receptor substrate 2
See related  HGNC:16971|MIM:607743|Ensembl:ENSG00000166225|HPRD:06372|
Locus tag  -
Gene type  protein-coding
Map location  12q15
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 2 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005158insulin receptor bindingIEA-
GO:0005069transmembrane receptor protein tyrosine kinase docking protein activityIEA-
GO:0005068transmembrane receptor protein tyrosine kinase adaptor protein activityTAS9660748 
GO:0005515protein bindingIPI9660748 
GO:0016299regulator of G-protein signaling activityTAS9660748 
GO:0019211phosphatase activator activityTAS9660748 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007405neuroblast proliferationIEAneuron (GO term level: 8)-
GO:0030900forebrain developmentIEABrain (GO term level: 8)-
GO:0000187activation of MAPK activityIEA-
GO:0001702gastrulation with mouth forming secondIEA-
GO:0001759induction of an organIEA-
GO:0007186G-protein coupled receptor protein signaling pathwayTAS9660748 
GO:0007242intracellular signaling cascadeEXP9069267 
GO:0007185transmembrane receptor protein tyrosine phosphatase signaling pathwayTAS9660748 
GO:0008543fibroblast growth factor receptor signaling pathwayTAS9660748 
GO:0008595determination of anterior/posterior axis, embryoIEA-
GO:0046619optic placode formation involved in camera-type eyeIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0012505endomembrane systemIEA-
GO:0005624membrane fractionTAS9660748 
GO:0005737cytoplasmIEA-
GO:0005768endosomeEXP7806500 |9182757 |10629055 
|16284401 
GO:0005886plasma membraneIEA-
GO:0005887integral to plasma membraneTAS9660748 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CBLC-CBL | CBL2 | RNF55Cas-Br-M (murine) ecotropic retroviral transforming sequence-HPRD,BioGRID11997436 
CRKCRKIIv-crk sarcoma virus CT10 oncogene homolog (avian)Reconstituted ComplexBioGRID10092678 
DDR1CAK | CD167 | DDR | EDDR1 | MCK10 | NEP | NTRK4 | PTK3 | PTK3A | RTK6 | TRKEdiscoidin domain receptor tyrosine kinase 1-HPRD10783152 
FGFR1BFGFR | CD331 | CEK | FGFBR | FLG | FLJ99988 | FLT2 | HBGFR | KAL2 | N-SAMfibroblast growth factor receptor 1-HPRD,BioGRID11090629 |11877385 
GRB2ASH | EGFRBP-GRB2 | Grb3-3 | MST084 | MSTP084growth factor receptor-bound protein 2Affinity Capture-Western
Reconstituted Complex		BioGRID8780727 |9182757 
|10092678 |11997436 
-HPRD8780727|9182757|11997436 |12402043 
INSRCD220 | HHF5insulin receptor-HPRD,BioGRID10650943 
NTRK1DKFZp781I14186 | MTC | TRK | TRK1 | TRKA | p140-TrkAneurotrophic tyrosine kinase, receptor, type 1TrkA interacts with FRS2-alpha. This interaction was modelled on a demonstrated interaction between human TrkA and mouse FRS2-alpha.BIND10629055 
-HPRD,BioGRID10092678 
NTRK2GP145-TrkB | TRKBneurotrophic tyrosine kinase, receptor, type 2Reconstituted ComplexBioGRID10092678 
NTRK3TRKC | gp145(trkC)neurotrophic tyrosine kinase, receptor, type 3Reconstituted ComplexBioGRID10092678 
PRKCIDXS1179E | MGC26534 | PKCI | nPKC-iotaprotein kinase C, iotain vitro
in vivo
Two-hybrid		BioGRID10383403 
PTPN11BPTP3 | CFC | MGC14433 | NS1 | PTP-1D | PTP2C | SH-PTP2 | SH-PTP3 | SHP2protein tyrosine phosphatase, non-receptor type 11-HPRD9632781 |11447289 
-HPRD,BioGRID9632781 
PTPRFFLJ43335 | FLJ45062 | FLJ45567 | LARprotein tyrosine phosphatase, receptor type, F-HPRD10822386 
RETCDHF12 | HSCR1 | MEN2A | MEN2B | MTC1 | PTC | RET-ELE1 | RET51ret proto-oncogeneRET interacts with FRS2BIND11390647 
-HPRD,BioGRID11360177 
SOS1GF1 | GGF1 | GINGF | HGF | NS4son of sevenless homolog 1 (Drosophila)-HPRD,BioGRID9182757 
 
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
let-7/98307030761Ahsa-let-7abrainUGAGGUAGUAGGUUGUAUAGUU
hsa-let-7bbrainUGAGGUAGUAGGUUGUGUGGUU
hsa-let-7cbrainUGAGGUAGUAGGUUGUAUGGUU
hsa-let-7dbrainAGAGGUAGUAGGUUGCAUAGU
hsa-let-7ebrainUGAGGUAGGAGGUUGUAUAGU
hsa-let-7fbrainUGAGGUAGUAGAUUGUAUAGUU
hsa-miR-98brainUGAGGUAGUAAGUUGUAUUGUU
hsa-let-7gSZUGAGGUAGUAGUUUGUACAGU
hsa-let-7ibrainUGAGGUAGUAGUUUGUGCUGU
miR-1/206395539621A,m8hsa-miR-1UGGAAUGUAAAGAAGUAUGUA
hsa-miR-206SZUGGAAUGUAAGGAAGUGUGUGG
hsa-miR-613AGGAAUGUUCCUUCUUUGCC
miR-101399139971Ahsa-miR-101UACAGUACUGUGAUAACUGAAG
miR-124/50627822788m8hsa-miR-506UAAGGCACCCUUCUGAGUAGA
hsa-miR-124brainUAAGGCACGCGGUGAAUGCC
miR-144399039971A,m8hsa-miR-144UACAGUAUAGAUGAUGUACUAG
miR-14544694475m8hsa-miR-145GUCCAGUUUUCCCAGGAAUCCCUU
miR-15339984004m8hsa-miR-153UUGCAUAGUCACAAAAGUGA
miR-17-5p/20/93.mr/106/519.d7247301Ahsa-miR-17-5pCAAAGUGCUUACAGUGCAGGUAGU
hsa-miR-20abrainUAAAGUGCUUAUAGUGCAGGUAG
hsa-miR-106aAAAAGUGCUUACAGUGCAGGUAGC
hsa-miR-106bSZUAAAGUGCUGACAGUGCAGAU
hsa-miR-20bSZCAAAGUGCUCAUAGUGCAGGUAG
hsa-miR-519dCAAAGUGCCUCCCUUUAGAGUGU
hsa-miR-17-5pCAAAGUGCUUACAGUGCAGGUAGU
hsa-miR-20abrainUAAAGUGCUUAUAGUGCAGGUAG
hsa-miR-106aAAAAGUGCUUACAGUGCAGGUAGC
hsa-miR-106bSZUAAAGUGCUGACAGUGCAGAU
hsa-miR-20bSZCAAAGUGCUCAUAGUGCAGGUAG
hsa-miR-519dCAAAGUGCCUCCCUUUAGAGUGU
miR-182199520011Ahsa-miR-182UUUGGCAAUGGUAGAACUCACA
hsa-miR-182UUUGGCAAUGGUAGAACUCACA
hsa-miR-182UUUGGCAAUGGUAGAACUCACA
miR-200bc/42910401046m8hsa-miR-200bUAAUACUGCCUGGUAAUGAUGAC
hsa-miR-200cUAAUACUGCCGGGUAAUGAUGG
hsa-miR-429UAAUACUGUCUGGUAAAACCGU
miR-204/2111431501A,m8hsa-miR-204brainUUCCCUUUGUCAUCCUAUGCCU
hsa-miR-211UUCCCUUUGUCAUCCUUCGCCU
miR-21448544921A,m8hsa-miR-21brainUAGCUUAUCAGACUGAUGUUGA
hsa-miR-590GAGCUUAUUCAUAAAAGUGCAG
miR-221/222419341991Ahsa-miR-221brainAGCUACAUUGUCUGCUGGGUUUC
hsa-miR-222brainAGCUACAUCUGGCUACUGGGUCUC
miR-25/32/92/363/36732343240m8hsa-miR-25brainCAUUGCACUUGUCUCGGUCUGA
hsa-miR-32UAUUGCACAUUACUAAGUUGC
hsa-miR-92UAUUGCACUUGUCCCGGCCUG
hsa-miR-367AAUUGCACUUUAGCAAUGGUGA
hsa-miR-92bSZUAUUGCACUCGUCCCGGCCUC
miR-33368536911Ahsa-miR-33GUGCAUUGUAGUUGCAUUG
hsa-miR-33bGUGCAUUGCUGUUGCAUUGCA
miR-3353543601Ahsa-miR-335brainUCAAGAGCAAUAACGAAAAAUGU
miR-374378337891Ahsa-miR-374UUAUAAUACAACCUGAUAAGUG
miR-381374437501Ahsa-miR-381UAUACAAGGGCAAGCUCUCUGU
hsa-miR-381UAUACAAGGGCAAGCUCUCUGU
hsa-miR-381UAUACAAGGGCAAGCUCUCUGU
miR-409-3p39543960m8hsa-miR-409-3pCGAAUGUUGCUCGGUGAACCCCU
miR-496435143571Ahsa-miR-496AUUACAUGGCCAAUCUC
miR-53939643970m8hsa-miR-539GGAGAAAUUAUCCUUGGUGUGU
miR-96390039061Ahsa-miR-96brainUUUGGCACUAGCACAUUUUUGC
hsa-miR-96brainUUUGGCACUAGCACAUUUUUGC
hsa-miR-96brainUUUGGCACUAGCACAUUUUUGC
hsa-miR-96brainUUUGGCACUAGCACAUUUUUGC
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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