Gene Page: RUVBL2

Summary
GeneID  10856
Symbol  RUVBL2
Synonyms  CGI-46|ECP51|INO80J|REPTIN|RVB2|TIH2|TIP48|TIP49B
Description  RuvB-like 2 (E. coli)
See related  HGNC:10475|MIM:604788|Ensembl:ENSG00000183207|HPRD:16070|
Locus tag  -
Gene type  protein-coding
Map location  19q13.3
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0089 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
YWHAQ0.910.92
LEPROTL10.910.92
BFAR0.910.94
DDB10.910.91
MARCH50.910.93
SEC61A10.910.92
DYM0.910.91
NUP1330.900.92
WDR40A0.900.93
PRUNE0.900.93
Top 10 negatively co-expressed genes
MT-CO2-0.75-0.85
AF347015.33-0.73-0.82
AF347015.31-0.73-0.82
AF347015.27-0.72-0.82
FXYD1-0.72-0.81
AF347015.8-0.72-0.84
MT-CYB-0.71-0.81
AF347015.21-0.69-0.82
C5orf53-0.68-0.72
AF347015.2-0.68-0.82
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0003684damaged DNA bindingIEA-
GO:0004003ATP-dependent DNA helicase activityTAS10428817 
GO:0005524ATP bindingIEA-
GO:0016787hydrolase activityIEA-
GO:0016887ATPase activityIDA10966108 
GO:0051082unfolded protein bindingTAS10524211 
GO:0042802identical protein bindingIDA10966108 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0001558regulation of cell growthIEA-
GO:0006355regulation of transcription, DNA-dependentIEA-
GO:0006350transcriptionIEA-
GO:0006310DNA recombinationTAS10428817 
GO:0006457protein foldingTAS10524211 
GO:0006281DNA repairTAS10428817 
GO:0016568chromatin modificationIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005829cytosolTAS10524211 
GO:0005622intracellularIDA11256614 
GO:0005634nucleusIDA10524211 
GO:0005737cytoplasmIEA-
GO:0016020membraneIEA-
GO:0016363nuclear matrixIEA-
GO:0035267NuA4 histone acetyltransferase complexIDA10966108 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ATF2CRE-BP1 | CREB2 | HB16 | MGC111558 | TREB7activating transcription factor 2-HPRD,BioGRID11713276 
BCAS1AIBC1 | NABC1breast carcinoma amplified sequence 1Affinity Capture-MSBioGRID17353931 
BCL3BCL4 | D19S37B-cell CLL/lymphoma 3RUVBL2 (reptin) interacts with BCL3.BIND15829968 
C19orf2FLJ10575 | NNX3 | RMP | URIchromosome 19 open reading frame 2-HPRD14615539 
C2orf44FLJ21945 | PP384chromosome 2 open reading frame 44Affinity Capture-MSBioGRID17353931 
CD824F9 | C33 | GR15 | IA4 | KAI1 | R2 | SAR2 | ST6 | TSPAN27CD82 moleculeRUVBL2 (reptin) interacts with the CD82 (KAI1) promoter.BIND15829968 
CTNNB1CTNNB | DKFZp686D02253 | FLJ25606 | FLJ37923catenin (cadherin-associated protein), beta 1, 88kDaCTNNB1 (beta-catenin) interacts with RUVBL2 (reptin).BIND15829968 
DNASE2DNASE2A | DNL | DNL2deoxyribonuclease II, lysosomalAffinity Capture-MSBioGRID17353931 
EP400CAGH32 | DKFZP434I225 | FLJ42018 | FLJ45115 | P400 | TNRC12E1A binding protein p400Affinity Capture-MSBioGRID11509179 
FASALPS1A | APO-1 | APT1 | CD95 | FAS1 | FASTM | TNFRSF6Fas (TNF receptor superfamily, member 6)RUVBL2 (reptin) interacts with the FAS promoter.BIND15829968 
FDFT1DGPT | ERG9 | SQS | SSfarnesyl-diphosphate farnesyltransferase 1Two-hybridBioGRID16169070 
HDAC1DKFZp686H12203 | GON-10 | HD1 | RPD3 | RPD3L1histone deacetylase 1RUVBL2 (reptin) interacts with HDAC1.BIND15829968 
HDAC4HA6116 | HD4 | HDAC-A | HDACA | KIAA0288histone deacetylase 4RUVBL2 (reptin) interacts with HDAC4.BIND15829968 
HDAC5FLJ90614 | HD5 | NY-CO-9histone deacetylase 5RUVBL2 (reptin) interacts with an unspecified isoform of HDAC5.BIND15829968 
IKBKEIKK-i | IKKE | IKKI | KIAA0151 | MGC125294 | MGC125295 | MGC125297inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilonAffinity Capture-MSBioGRID17353931 
MAP3K14FTDCR1B | HS | HSNIK | NIKmitogen-activated protein kinase kinase kinase 14-HPRD14743216 
MAP3K3MAPKKK3 | MEKK3mitogen-activated protein kinase kinase kinase 3-HPRD14743216 
MAP3K7TAK1 | TGF1amitogen-activated protein kinase kinase kinase 7-HPRD14743216 
MAP3K7IP2FLJ21885 | KIAA0733 | TAB2mitogen-activated protein kinase kinase kinase 7 interacting protein 2-HPRD14743216 
MYCbHLHe39 | c-Mycv-myc myelocytomatosis viral oncogene homolog (avian)Co-purificationBioGRID11839798 
NEK6SID6-1512NIMA (never in mitosis gene a)-related kinase 6Affinity Capture-MSBioGRID17353931 
NFKB1DKFZp686C01211 | EBP-1 | KBF1 | MGC54151 | NF-kappa-B | NFKB-p105 | NFKB-p50 | p105nuclear factor of kappa light polypeptide gene enhancer in B-cells 1-HPRD14743216 
NFKB1 (p50) interacts with RUVBL2 (reptin).BIND15829968 
NFKB2LYT-10 | LYT10nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)-HPRD14743216 
NFKBIEIKBEnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon-HPRD14743216 
NME2MGC111212 | NDPK-B | NDPKB | NM23-H2 | NM23B | pufnon-metastatic cells 2, protein (NM23B) expressed inAffinity Capture-MSBioGRID17353931 
NOP5/NOP58HSPC120nucleolar protein NOP5/NOP58-HPRD12417735 
PCNAMGC8367proliferating cell nuclear antigenAffinity Capture-MSBioGRID12171929 
PLOD2LH2 | TLHprocollagen-lysine, 2-oxoglutarate 5-dioxygenase 2Affinity Capture-MSBioGRID17353931 
PON2-paraoxonase 2Affinity Capture-MSBioGRID17353931 
RELAMGC131774 | NFKB3 | p65v-rel reticuloendotheliosis viral oncogene homolog A (avian)-HPRD14743216 
RGS20RGSZ1 | ZGAP1regulator of G-protein signaling 20Affinity Capture-MSBioGRID17353931 
RIOK3DKFZp779L1370 | SUDDRIO kinase 3 (yeast)Affinity Capture-MSBioGRID17353931 
RP11-529I10.4DKFZp566F084deleted in a mouse model of primary ciliary dyskinesiaAffinity Capture-MS
Two-hybrid		BioGRID16189514 |17353931 
RPS11-ribosomal protein S11Affinity Capture-MSBioGRID17353931 
RUVBL1ECP54 | INO80H | NMP238 | PONTIN | Pontin52 | RVB1 | TIH1 | TIP49 | TIP49ARuvB-like 1 (E. coli)Affinity Capture-MSBioGRID17353931 
SSSCA1p27Sjogren syndrome/scleroderma autoantigen 1Affinity Capture-MSBioGRID17353931 
STAP1BRDG1 | STAP-1signal transducing adaptor family member 1Affinity Capture-MSBioGRID14615539 
TBK1FLJ11330 | NAK | T2KTANK-binding kinase 1-HPRD14743216 
TRAF2MGC:45012 | TRAP | TRAP3TNF receptor-associated factor 2-HPRD14743216 
UQCRC1D3S3191 | QCR1 | UQCR1ubiquinol-cytochrome c reductase core protein IAffinity Capture-MSBioGRID17353931 
USP7HAUSP | TEF1ubiquitin specific peptidase 7 (herpes virus-associated)Affinity Capture-MSBioGRID17353931 
 


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