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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets

Gene Ranking Integration

Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets Datasets Gene Ranking

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Gene Page: WWP1

Summary

GeneID

11059

Symbol

WWP1

Synonyms

AIP5|DKFZp434D2111|Tiul1|hSDRP1

Description

WW domain containing E3 ubiquitin protein ligase 1

Locus tag

Gene type

protein-coding

Map location

8q21

Gene in Data Sources

Gene set name

Method of gene set

Evidence

Info

GO_Annotation

Mapping neuro-related keywords to Gene Ontology annotations

Hits with neuro-related keywords: 1

General Gene Expression (microarray) ?

Gene Expression in Brain Regions (new)

Top co-expressed genes in Brain Regions (new)

Gene

Pearson's Correlation

Spearman's Correlation

Top 10 positively co-expressed genes

ARD1A

0.55

0.39

STX10

0.55

0.53

AL022328.1

0.53

0.52

RPS27

0.53

0.46

C16orf79

0.52

0.45

AC008763.1

0.52

0.36

CHMP4A

0.51

0.41

STRA13

0.51

0.43

BLOC1S1

0.50

0.46

RPL36A

0.50

0.33

Top 10 negatively co-expressed genes

TMEM30A

-0.37

-0.40

NET1

-0.36

-0.34

RNF14

-0.36

-0.41

AL136219.3

-0.35

-0.36

HSD17B12

-0.35

-0.37

VDAC1

-0.35

-0.40

RTN3

-0.35

-0.38

BAG4

-0.35

-0.40

SNAP91

-0.34

-0.36

CDC27

-0.34

-0.36

Gene Ontology

Molecular function

GO term

Evidence

Neuro keywords

PubMed ID

GO:0005515

protein binding

IPI

9647693

GO:0005515

protein binding

ISS

GO:0004842

ubiquitin-protein ligase activity

TAS

9169421

GO:0016874

ligase activity

IEA

GO:0016881

acid-amino acid ligase activity

IEA

Biological process

GO term

Evidence

Neuro keywords

PubMed ID

GO:0007417

central nervous system development

NAS

Brain (GO term level: 6)

9647693

GO:0006464

protein modification process

IEA

GO:0006511

ubiquitin-dependent protein catabolic process

IEA

GO:0007165

signal transduction

NAS

9169421

GO:0016567

protein ubiquitination

TAS

12535537

GO:0016481

negative regulation of transcription

ISS

GO:0044419

interspecies interaction between organisms

IEA

GO:0046718

entry of virus into host cell

TAS

12450395

Cellular component

GO term

Evidence

Neuro keywords

PubMed ID

GO:0000151

ubiquitin ligase complex

NAS

9169421

GO:0005622

intracellular

IEA

Protein-protein Interactions

Shown by network

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
ATN1	B37 \| D12S755E \| DRPLA \| NOD	atrophin 1	-	HPRD,BioGRID	9647693
ATN1	B37 \| D12S755E \| DRPLA \| NOD	atrophin 1	Atrophin-1 interacts with AIP-5.	BIND	9647693
CPSF6	CFIM \| CFIM68 \| HPBRII-4 \| HPBRII-7	cleavage and polyadenylation specific factor 6, 68kDa	Affinity Capture-Western Two-hybrid	BioGRID	16189514
DAZAP2	KIAA0058 \| MGC14319 \| MGC766 \| PRTB	DAZ associated protein 2	Two-hybrid	BioGRID	16189514
DIDO1	BYE1 \| C20orf158 \| DATF1 \| DIDO2 \| DIDO3 \| DIO-1 \| DIO1 \| DKFZp434P1115 \| FLJ11265 \| KIAA0333 \| MGC16140 \| dJ885L7.8	death inducer-obliterator 1	Two-hybrid	BioGRID	16189514
EWSR1	EWS	Ewing sarcoma breakpoint region 1	Two-hybrid	BioGRID	16189514
IL6R	CD126 \| IL-6R-1 \| IL-6R-alpha \| IL6RA \| MGC104991	interleukin 6 receptor	-	HPRD	9169421
KLF2	LKLF	Kruppel-like factor 2 (lung)	-	HPRD,BioGRID	11375995
RASA1	CM-AVM \| CMAVM \| DKFZp434N071 \| GAP \| PKWS \| RASA \| RASGAP \| p120GAP \| p120RASGAP	RAS p21 protein activator (GTPase activating protein) 1	-	HPRD	9169421
SCNN1A	ENaCa \| ENaCalpha \| FLJ21883 \| SCNEA \| SCNN1	sodium channel, nonvoltage-gated 1 alpha	Two-hybrid	BioGRID	14556380
TP53BP2	53BP2 \| ASPP2 \| BBP \| PPP1R13A \| p53BP2	tumor protein p53 binding protein, 2	-	HPRD	9169421
WBP1	MGC15305 \| WBP-1	WW domain binding protein 1	-	HPRD,BioGRID	9169421
WBP2	MGC18269 \| WBP-2	WW domain binding protein 2	Protein-peptide	BioGRID	9169421
ZNF638	DKFZp686P1231 \| MGC26130 \| MGC90196 \| NP220 \| ZFML \| Zfp638	zinc finger protein 638	Two-hybrid	BioGRID	16189514

miRNA Targets ?

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-142-5p	169	175	m8	hsa-miR-142-5p	CAUAAAGUAGAAAGCACUAC
miR-15/16/195/424/497	517	523	m8	hsa-miR-15a^brain	UAGCAGCACAUAAUGGUUUGUG
				hsa-miR-16^brain	UAGCAGCACGUAAAUAUUGGCG
				hsa-miR-15b^brain	UAGCAGCACAUCAUGGUUUACA
				hsa-miR-195^SZ	UAGCAGCACAGAAAUAUUGGC
				hsa-miR-424	CAGCAGCAAUUCAUGUUUUGAA
				hsa-miR-497	CAGCAGCACACUGUGGUUUGU
miR-153	144	150	1A	hsa-miR-153	UUGCAUAGUCACAAAAGUGA
miR-19	57	63	1A	hsa-miR-19a	UGUGCAAAUCUAUGCAAAACUGA
miR-19	57	63	1A	hsa-miR-19b	UGUGCAAAUCCAUGCAAAACUGA
miR-191	125	131	m8	hsa-miR-191^brain	CAACGGAAUCCCAAAAGCAGCU
miR-21	74	80	m8	hsa-miR-21^brain	UAGCUUAUCAGACUGAUGUUGA
miR-21	74	80	m8	hsa-miR-590	GAGCUUAUUCAUAAAAGUGCAG
miR-335	24	30	m8	hsa-miR-335^brain	UCAAGAGCAAUAACGAAAAAUGU
miR-448	143	150	1A,m8	hsa-miR-448	UUGCAUAUGUAGGAUGUCCCAU
miR-7	131	137	1A	hsa-miR-7^SZ	UGGAAGACUAGUGAUUUUGUUG

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.