Gene Page: RAPGEF4

Summary
GeneID  11069
Symbol  RAPGEF4
Synonyms  CAMP-GEFII|CGEF2|EPAC2|Nbla00496
Description  Rap guanine nucleotide exchange factor (GEF) 4
See related  HGNC:16626|MIM:606058|Ensembl:ENSG00000091428|HPRD:06929|
Locus tag  -
Gene type  protein-coding
Map location  2q31-q32
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0312 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0005085guanyl-nucleotide exchange factor activityTAS9856955 
GO:0005515protein bindingIPI11438518 
GO:0008603cAMP-dependent protein kinase regulator activityIEA-
GO:0030552cAMP bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0001932regulation of protein amino acid phosphorylationIEA-
GO:0007186G-protein coupled receptor protein signaling pathwayTAS9856955 
GO:0006887exocytosisIEA-
GO:0051056regulation of small GTPase mediated signal transductionIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005622intracellularIEA-
GO:0005624membrane fractionTAS10777494 
GO:0005737cytoplasmIEA-
GO:0016020membraneIEA-
GO:0005952cAMP-dependent protein kinase complexIEA-
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ABCC8ABC36 | HHF1 | HI | HRINS | MRP8 | PHHI | SUR | SUR1 | TNDM2ATP-binding cassette, sub-family C (CFTR/MRP), member 8Affinity Capture-WesternBioGRID14660679 
RAP1AKREV-1 | KREV1 | RAP1 | SMGP21RAP1A, member of RAS oncogene familyBiochemical ActivityBioGRID10777494 
Rap1A interacts with Epac2. This interaction was modeled on a demonstrated interaction between human Rap1A and mouse Epac2.BIND15856025 
RAP2AK-REV | KREV | RAP2 | RbBP-30RAP2A, member of RAS oncogene familyBiochemical ActivityBioGRID10777494 
RIMS2DKFZp781A0653 | KIAA0751 | OBOE | RAB3IP3 | RIM2regulating synaptic membrane exocytosis 2-HPRD,BioGRID11598134 |14660679 
RRAS2TC21related RAS viral (r-ras) oncogene homolog 2-HPRD12384139 
 
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-130/301886892m8hsa-miR-130abrainCAGUGCAAUGUUAAAAGGGCAU
hsa-miR-301CAGUGCAAUAGUAUUGUCAAAGC
hsa-miR-130bbrainCAGUGCAAUGAUGAAAGGGCAU
hsa-miR-454-3pUAGUGCAAUAUUGCUUAUAGGGUUU
miR-1557827881Ahsa-miR-155UUAAUGCUAAUCGUGAUAGGGG
miR-17-5p/20/93.mr/106/519.d888894m8hsa-miR-17-5pCAAAGUGCUUACAGUGCAGGUAGU
hsa-miR-20abrainUAAAGUGCUUAUAGUGCAGGUAG
hsa-miR-106aAAAAGUGCUUACAGUGCAGGUAGC
hsa-miR-106bSZUAAAGUGCUGACAGUGCAGAU
hsa-miR-20bSZCAAAGUGCUCAUAGUGCAGGUAG
hsa-miR-519dCAAAGUGCCUCCCUUUAGAGUGU
miR-1829629681Ahsa-miR-182UUUGGCAAUGGUAGAACUCACA
miR-19885891m8hsa-miR-19aUGUGCAAAUCUAUGCAAAACUGA
hsa-miR-19bUGUGCAAAUCCAUGCAAAACUGA
miR-203.17237301A,m8hsa-miR-203UGAAAUGUUUAGGACCACUAG
miR-2055125181Ahsa-miR-205UCCUUCAUUCCACCGGAGUCUG
miR-2187357411Ahsa-miR-218brainUUGUGCUUGAUCUAACCAUGU
miR-30-5p6166231A,m8hsa-miR-30a-5pUGUAAACAUCCUCGACUGGAAG
hsa-miR-30cbrainUGUAAACAUCCUACACUCUCAGC
hsa-miR-30dSZUGUAAACAUCCCCGACUGGAAG
hsa-miR-30bSZUGUAAACAUCCUACACUCAGCU
hsa-miR-30e-5pUGUAAACAUCCUUGACUGGA
miR-3657807871A,m8hsa-miR-365UAAUGCCCCUAAAAAUCCUUAU
miR-969619681A,m8hsa-miR-96brainUUUGGCACUAGCACAUUUUUGC
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


Copyright © Bioinformatics and Systems Medicine Laboratory All Rights Reserved since 2009.