Gene Page: BTN3A1
Summary ?
| GeneID | 11119 |
| Symbol | BTN3A1 |
| Synonyms | BT3.1|BTF5|BTN3.1|CD277 |
| Description | butyrophilin subfamily 3 member A1 |
| Reference | MIM:613593|HGNC:HGNC:1138|Ensembl:ENSG00000026950|HPRD:10693|Vega:OTTHUMG00000014449 |
| Gene type | protein-coding |
| Map location | 6p22.1 |
| Pascal p-value | 1E-12 |
| Sherlock p-value | 0.483 |
| eGene | Cerebellum Putamen basal ganglia Myers' cis & trans |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| GSMA_I | Genome scan meta-analysis | Psr: 0.033 |
Section I. Genetics and epigenetics annotation
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs10994209 | chr10 | 61877705 | BTN3A1 | 11119 | 0.18 | trans | ||
| rs13192826 | 6 | 25496657 | BTN3A1 | ENSG00000026950.12 | 6.41043E-6 | 0.05 | -905808 | gtex_brain_putamen_basal |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| TGM3 | 0.61 | 0.24 |
| KIAA1772 | 0.55 | 0.33 |
| ARHGAP6 | 0.55 | 0.35 |
| MATN2 | 0.53 | 0.37 |
| SYTL1 | 0.52 | 0.26 |
| FAM70A | 0.51 | 0.33 |
| SLC4A11 | 0.50 | 0.36 |
| CYP4V2 | 0.48 | 0.52 |
| SREBF1 | 0.47 | 0.49 |
| KLK7 | 0.46 | 0.21 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| IL32 | -0.29 | -0.39 |
| CLEC3B | -0.25 | -0.35 |
| TIMM8B | -0.24 | -0.33 |
| SPINK8 | -0.24 | -0.28 |
| CARD16 | -0.23 | -0.22 |
| GNG11 | -0.23 | -0.25 |
| RPL35 | -0.23 | -0.32 |
| BID | -0.22 | -0.26 |
| COMMD7 | -0.22 | -0.26 |
| TTC9B | -0.22 | -0.29 |
Section III. Gene Ontology annotation
| Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0006629 | lipid metabolic process | TAS | 9149941 | |
| Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0016020 | membrane | IEA | - | |
| GO:0016021 | integral to membrane | IEA | - |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| WATANABE RECTAL CANCER RADIOTHERAPY RESPONSIVE UP | 108 | 67 | All SZGR 2.0 genes in this pathway |
| BERTUCCI MEDULLARY VS DUCTAL BREAST CANCER UP | 206 | 111 | All SZGR 2.0 genes in this pathway |
| WATANABE ULCERATIVE COLITIS WITH CANCER DN | 14 | 9 | All SZGR 2.0 genes in this pathway |
| PUJANA ATM PCC NETWORK | 1442 | 892 | All SZGR 2.0 genes in this pathway |
| BUYTAERT PHOTODYNAMIC THERAPY STRESS UP | 811 | 508 | All SZGR 2.0 genes in this pathway |
| WANG CISPLATIN RESPONSE AND XPC DN | 228 | 146 | All SZGR 2.0 genes in this pathway |
| JI RESPONSE TO FSH UP | 74 | 56 | All SZGR 2.0 genes in this pathway |
| DOUGLAS BMI1 TARGETS DN | 314 | 188 | All SZGR 2.0 genes in this pathway |
| WALLACE PROSTATE CANCER RACE UP | 299 | 167 | All SZGR 2.0 genes in this pathway |