Gene Page: LZTS1

Summary
GeneID  11178
Symbol  LZTS1
Synonyms  F37|FEZ1
Description  leucine zipper, putative tumor suppressor 1
See related  HGNC:13861|MIM:606551|Ensembl:ENSG00000061337|HPRD:05945|
Locus tag  -
Gene type  protein-coding
Map location  8p22
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_Igenome scan meta-analysisPsr: 0.031 
GSMA_IIEgenome scan meta-analysis (European-ancestry samples)Psr: 0.00057 
GSMA_IIAgenome scan meta-analysis (All samples)Psr: 0.03086 
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 2 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
TTC7B0.760.77
TOM1L20.740.77
SNPH0.730.74
ITPK10.720.75
CAMTA20.720.73
SHANK30.720.71
PPARD0.720.75
CTSA0.720.71
ACSL60.710.71
AC005277.10.710.73
Top 10 negatively co-expressed genes
EXOSC8-0.52-0.51
BCL7C-0.52-0.57
AC011475.1-0.50-0.51
SNRPG-0.49-0.55
DYNLT1-0.49-0.54
RBMX2-0.49-0.49
RPS27A-0.48-0.59
C9orf46-0.48-0.51
RPL27A-0.47-0.59
CYP2R1-0.46-0.41
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003700transcription factor activityTAS10097140 
GO:0005515protein bindingIPI17349584 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006355regulation of transcription, DNA-dependentNAS-
GO:0006350transcriptionNAS10097140 
GO:0045786negative regulation of cell cycleIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0042995cell projectionIEAaxon (GO term level: 4)-
GO:0045211postsynaptic membraneIEASynap, Neurotransmitter (GO term level: 5)-
GO:0045202synapseIEAneuron, Synap, Neurotransmitter, Glial (GO term level: 2)-
GO:0005794Golgi apparatusIDA18029348 
GO:0005634nucleusNAS-
GO:0005737cytoplasmIEA-
GO:0005886plasma membraneIEA-
GO:0030054cell junctionIEA-
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CDC2CDC28A | CDK1 | DKFZp686L20222 | MGC111195cell division cycle 2, G1 to S and G2 to M-HPRD,BioGRID11504921 
EEF1GEF1G | GIG35eukaryotic translation elongation factor 1 gammaAffinity Capture-Western
Reconstituted Complex
Two-hybrid
BioGRID11504921 
 
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-124/50622822288m8hsa-miR-506UAAGGCACCCUUCUGAGUAGA
hsa-miR-124brainUAAGGCACGCGGUGAAUGCC
miR-1357707771A,m8hsa-miR-135aUAUGGCUUUUUAUUCCUAUGUGA
hsa-miR-135bUAUGGCUUUUCAUUCCUAUGUG
hsa-miR-135aUAUGGCUUUUUAUUCCUAUGUGA
hsa-miR-135bUAUGGCUUUUCAUUCCUAUGUG
miR-149174517511Ahsa-miR-149brainUCUGGCUCCGUGUCUUCACUCC
miR-539354135481A,m8hsa-miR-539GGAGAAAUUAUCCUUGGUGUGU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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