Gene Page: CNTF

Summary ?
GeneID1270
SymbolCNTF
SynonymsHCNTF
Descriptionciliary neurotrophic factor
ReferenceMIM:118945|HGNC:HGNC:2169|Ensembl:ENSG00000242689|HPRD:00347|Vega:OTTHUMG00000137476
Gene typeprotein-coding
Map location11q12.2
Pascal p-value0.745
Fetal beta0.195

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenics,schizophreniasClick to show details
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 2 

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005127ciliary neurotrophic factor receptor bindingTASneurotrophic (GO term level: 6)1714745 
GO:0005515protein bindingIPI17353931 
GO:0008083growth factor activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007399nervous system developmentIEAneurite (GO term level: 5)-
GO:0007165signal transductionNAS1840538 
GO:0007275multicellular organismal developmentIEA-
GO:0030154cell differentiationIEA-
GO:0040007growthIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005737cytoplasmIEA-

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
APOEAD2 | LPG | MGC1571 | apoproteinapolipoprotein EApolipoprotein E binds to ciliary neurotrophic factorBIND9236223 
CNTFHCNTFciliary neurotrophic factor-HPRD,BioGRID7796798 
CNTFRMGC1774ciliary neurotrophic factor receptor-HPRD,BioGRID7810882 |10812968 
EIF3EEIF3-P48 | EIF3S6 | INT6 | eIF3-p46eukaryotic translation initiation factor 3, subunit EAffinity Capture-MSBioGRID17353931 
EXT1EXT | LGCR | LGS | TRPS2 | ttvexostoses (multiple) 1Affinity Capture-MSBioGRID17353931 
EXT2SOTVexostoses (multiple) 2Affinity Capture-MSBioGRID17353931 
ICA1ICA69 | ICAp69islet cell autoantigen 1, 69kDaAffinity Capture-MSBioGRID17353931 
IL6RCD126 | IL-6R-1 | IL-6R-alpha | IL6RA | MGC104991interleukin 6 receptor-HPRD,BioGRID1281789 
IL6STCD130 | CDw130 | GP130 | GP130-RAPS | IL6R-betainterleukin 6 signal transducer (gp130, oncostatin M receptor)-HPRD12643274 
LIFRCD118 | FLJ98106 | FLJ99923 | LIF-R | SJS2 | STWS | SWSleukemia inhibitory factor receptor alpha-HPRD12643274 
STK16FLJ39635 | KRCT | MPSK | PKL12 | TSF1serine/threonine kinase 16Affinity Capture-MSBioGRID17353931 
VHLHRCA1 | RCA1 | VHL1von Hippel-Lindau tumor suppressorAffinity Capture-MSBioGRID17353931 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG CYTOKINE CYTOKINE RECEPTOR INTERACTION 267161All SZGR 2.0 genes in this pathway
KEGG JAK STAT SIGNALING PATHWAY 155105All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN 17811082All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 UNSTIMULATED 1229713All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS DN 366257All SZGR 2.0 genes in this pathway
PANGAS TUMOR SUPPRESSION BY SMAD1 AND SMAD5 DN 157106All SZGR 2.0 genes in this pathway
CHYLA CBFA2T3 TARGETS DN 242146All SZGR 2.0 genes in this pathway
NABA SECRETED FACTORS 344197All SZGR 2.0 genes in this pathway
NABA MATRISOME ASSOCIATED 753411All SZGR 2.0 genes in this pathway
NABA MATRISOME 1028559All SZGR 2.0 genes in this pathway