Gene Page: PTCHD1
Summary ?
| GeneID | 139411 |
| Symbol | PTCHD1 |
| Synonyms | AUTSX4 |
| Description | patched domain containing 1 |
| Reference | MIM:300828|HGNC:HGNC:26392|HPRD:06548| |
| Gene type | protein-coding |
| Map location | Xp22.11 |
| Sherlock p-value | 0.147 |
| Fetal beta | -0.598 |
| eGene | Myers' cis & trans |
| Support | Potential synaptic genes |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| PMID:cooccur | High-throughput literature-search | Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included. | |
| Literature | High-throughput literature-search | Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias | Click to show details |
Section I. Genetics and epigenetics annotation
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs16829545 | chr2 | 151977407 | PTCHD1 | 139411 | 4.424E-13 | trans | ||
| rs7584986 | chr2 | 184111432 | PTCHD1 | 139411 | 1.339E-4 | trans | ||
| rs3118341 | chr9 | 25185518 | PTCHD1 | 139411 | 0.13 | trans | ||
| rs2393316 | chr10 | 59333070 | PTCHD1 | 139411 | 0.08 | trans | ||
| rs16955618 | chr15 | 29937543 | PTCHD1 | 139411 | 1.422E-15 | trans | ||
| rs1041786 | chr21 | 22617710 | PTCHD1 | 139411 | 0.12 | trans |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| BENPORATH SUZ12 TARGETS | 1038 | 678 | All SZGR 2.0 genes in this pathway |
| CHEN METABOLIC SYNDROM NETWORK | 1210 | 725 | All SZGR 2.0 genes in this pathway |
| ZWANG TRANSIENTLY UP BY 1ST EGF PULSE ONLY | 1839 | 928 | All SZGR 2.0 genes in this pathway |