Gene Page: CRYBB3
Summary ?
| GeneID | 1417 |
| Symbol | CRYBB3 |
| Synonyms | CATCN2|CRYB3|CTRCT22 |
| Description | crystallin beta B3 |
| Reference | MIM:123630|HGNC:HGNC:2400|Ensembl:ENSG00000100053|HPRD:00431|Vega:OTTHUMG00000150869 |
| Gene type | protein-coding |
| Map location | 22q11.23 |
| Pascal p-value | 0.006 |
| eGene | Cortex Frontal Cortex BA9 Myers' cis & trans |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| GSMA_I | Genome scan meta-analysis | Psr: 0.031 |
Section I. Genetics and epigenetics annotation
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs695809 | chr22 | 26278127 | CRYBB3 | 1417 | 0.1 | cis | ||
| rs1469347 | chr2 | 126401820 | CRYBB3 | 1417 | 0.19 | trans |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| PDE1A | 0.77 | 0.75 |
| OSBPL10 | 0.77 | 0.62 |
| LMO7 | 0.76 | 0.69 |
| C14orf23 | 0.76 | 0.63 |
| GPD1L | 0.75 | 0.64 |
| STT3B | 0.75 | 0.53 |
| ST18 | 0.74 | 0.43 |
| LMO3 | 0.74 | 0.73 |
| SATB1 | 0.73 | 0.64 |
| TBR1 | 0.73 | 0.62 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| AL139819.3 | -0.49 | -0.56 |
| AF347015.26 | -0.48 | -0.50 |
| AF347015.8 | -0.47 | -0.49 |
| AF347015.15 | -0.47 | -0.48 |
| AF347015.2 | -0.46 | -0.44 |
| MT-CO2 | -0.46 | -0.46 |
| MT-CYB | -0.45 | -0.47 |
| TMEM51 | -0.45 | -0.48 |
| LIMS2 | -0.45 | -0.45 |
| HSD17B14 | -0.45 | -0.49 |
Section III. Gene Ontology annotation
| Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0005212 | structural constituent of eye lens | IEA | - | |
| Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0007601 | visual perception | TAS | 8999933 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| MCCABE BOUND BY HOXC6 | 469 | 239 | All SZGR 2.0 genes in this pathway |
| MCCABE HOXC6 TARGETS CANCER UP | 31 | 23 | All SZGR 2.0 genes in this pathway |
| YOSHIMURA MAPK8 TARGETS UP | 1305 | 895 | All SZGR 2.0 genes in this pathway |
| SHEDDEN LUNG CANCER GOOD SURVIVAL A12 | 317 | 177 | All SZGR 2.0 genes in this pathway |
| MIKKELSEN MEF HCP WITH H3 UNMETHYLATED | 228 | 119 | All SZGR 2.0 genes in this pathway |
| MARTENS TRETINOIN RESPONSE UP | 857 | 456 | All SZGR 2.0 genes in this pathway |
| KIM BIPOLAR DISORDER OLIGODENDROCYTE DENSITY CORR DN | 88 | 59 | All SZGR 2.0 genes in this pathway |
| ZWANG TRANSIENTLY UP BY 2ND EGF PULSE ONLY | 1725 | 838 | All SZGR 2.0 genes in this pathway |