Gene Page: CTGF

Summary
GeneID  1490
Symbol  CTGF
Synonyms  CCN2|HCS24|IGFBP8|MGC102839|NOV2
Description  connective tissue growth factor
See related  HGNC:2500|MIM:121009|Ensembl:ENSG00000118523|HPRD:00412|
Locus tag  -
Gene type  protein-coding
Map location  6q23.1
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0312 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
WASF10.870.83
B3GAT10.870.86
DSCAM0.860.88
SPTAN10.860.85
OSBPL100.860.87
RP1-21O18.10.860.87
NNT0.850.86
HECA0.850.88
NMNAT20.850.86
R3HDM20.850.88
Top 10 negatively co-expressed genes
AF347015.21-0.67-0.74
SERPINB6-0.67-0.70
HIGD1B-0.66-0.70
MT-CO2-0.66-0.69
AF347015.31-0.66-0.69
C1orf54-0.65-0.79
GNG11-0.65-0.70
AP002478.3-0.64-0.72
NOSTRIN-0.64-0.67
IFI27-0.63-0.65
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005178integrin bindingIEA-
GO:0005515protein bindingIEA-
GO:0005520insulin-like growth factor bindingTAS9371786 
GO:0008201heparin bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0001558regulation of cell growthIEA-
GO:0001525angiogenesisIEA-
GO:0001502cartilage condensationIEA-
GO:0001503ossificationIEA-
GO:0007160cell-matrix adhesionIEA-
GO:0007155cell adhesionIEA-
GO:0007229integrin-mediated signaling pathwayIEA-
GO:0006260DNA replicationIEA-
GO:0008543fibroblast growth factor receptor signaling pathwayIEA-
GO:0008544epidermis developmentTAS10809757 
GO:0009611response to woundingTAS10809757 
GO:0016477cell migrationIEA-
GO:0030154cell differentiationIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005576extracellular regionIEA-
GO:0005578proteinaceous extracellular matrixTAS10809757 
GO:0005886plasma membraneTAS10809757 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ERBB4HER4 | MGC138404 | p180erbB4v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)-HPRD12297288 
LRP1A2MR | APOER | APR | CD91 | FLJ16451 | IGFBP3R | LRP | MGC88725 | TGFBR5low density lipoprotein-related protein 1 (alpha-2-macroglobulin receptor)-HPRD14585398 
NOVCCN3 | IGFBP9nephroblastoma overexpressed genein vitro
Two-hybrid		BioGRID9927660 
TGFB1CED | DPD1 | TGFB | TGFbetatransforming growth factor, beta 1-HPRD,BioGRID10457363 
TGFB2MGC116892 | TGF-beta2transforming growth factor, beta 2-HPRD,BioGRID10457363 
TGFB3ARVD | FLJ16571 | TGF-beta3transforming growth factor, beta 3-HPRD,BioGRID10457363 
VEGFAMGC70609 | VEGF | VEGF-A | VPFvascular endothelial growth factor A-HPRD,BioGRID11744618 
 
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-14353591Ahsa-miR-143brainUGAGAUGAAGCACUGUAGCUCA
miR-1495685741Ahsa-miR-149brainUCUGGCUCCGUGUCUUCACUCC
miR-1810461052m8hsa-miR-18aUAAGGUGCAUCUAGUGCAGAUA
hsa-miR-18bUAAGGUGCAUCUAGUGCAGUUA
miR-1910431049m8hsa-miR-19aUGUGCAAAUCUAUGCAAAACUGA
hsa-miR-19bUGUGCAAAUCCAUGCAAAACUGA
miR-199183189m8hsa-miR-199aCCCAGUGUUCAGACUACCUGUUC
hsa-miR-199bCCCAGUGUUUAGACUAUCUGUUC
miR-2638441Ahsa-miR-26abrainUUCAAGUAAUCCAGGAUAGGC
hsa-miR-26bSZUUCAAGUAAUUCAGGAUAGGUU
miR-3759069121Ahsa-miR-375UUUGUUCGUUCGGCUCGCGUGA
miR-485-5p7127181Ahsa-miR-485-5pAGAGGCUGGCCGUGAUGAAUUC
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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