SZGR2

Summary ?

GeneID	1499
Symbol	CTNNB1
Synonyms	CTNNB\|MRD19\|armadillo
Description	catenin beta 1
Reference	MIM:116806\|HGNC:HGNC:2514\|Ensembl:ENSG00000168036\|HPRD:00286\|Vega:OTTHUMG00000131393
Gene type	protein-coding
Map location	3p21
Pascal p-value	0.636
Fetal beta	-0.341
DMG	1 (# studies)
eGene	Putamen basal ganglia
Support	INTRACELLULAR SIGNAL TRANSDUCTION G2Cdb.humanNRC G2Cdb.humanPSD G2Cdb.humanPSP CompositeSet Darnell FMRP targets Potential synaptic genes

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS
DMG:Jaffe_2016	Genome-wide DNA methylation analysis	This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05.	1
PMID:cooccur	High-throughput literature-search	Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature	High-throughput literature-search	Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenics,schizophrenias	Click to show details
Network	Shortest path distance of core genes in the Human protein-protein interaction network	Contribution to shortest path in PPI network: 1.9379

Section I. Genetics and epigenetics annotation

Differentially methylated gene

Probe	Chromosome	Position	Nearest gene	P (dis)	Beta (dis)	FDR (dis)	Study
cg04180460	3	41240962	CTNNB1	4.47E-10	-0.013	8.02E-7	DMG:Jaffe_2016

eQTL annotation

SNP ID	Chromosome	Position	eGene	Gene Entrez ID	pvalue	qvalue	TSS distance	eQTL type
rs55840513	3	41239045	CTNNB1	ENSG00000168036.12	6.36481E-6	0.05	2717	gtex_brain_putamen_basal
rs13075993	3	41260017	CTNNB1	ENSG00000168036.12	6.68607E-6	0.05	23689	gtex_brain_putamen_basal
rs3774369	3	41267525	CTNNB1	ENSG00000168036.12	6.73806E-6	0.05	31197	gtex_brain_putamen_basal
rs11564454	3	41274477	CTNNB1	ENSG00000168036.12	6.64323E-6	0.05	38149	gtex_brain_putamen_basal
rs3774371	3	41276166	CTNNB1	ENSG00000168036.12	6.67766E-6	0.05	39838	gtex_brain_putamen_basal
rs11564465	3	41277040	CTNNB1	ENSG00000168036.12	6.67766E-6	0.05	40712	gtex_brain_putamen_basal
rs150512515	3	41281409	CTNNB1	ENSG00000168036.12	6.67626E-6	0.05	45081	gtex_brain_putamen_basal
rs11129895	3	41283382	CTNNB1	ENSG00000168036.12	6.68625E-6	0.05	47054	gtex_brain_putamen_basal

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0004871	signal transducer activity	NAS		10192393
GO:0003713	transcription coactivator activity	NAS		15572661
GO:0005198	structural molecule activity	IEA		-
GO:0008022	protein C-terminus binding	IPI		10773885
GO:0050681	androgen receptor binding	NAS		15572661
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0001837	epithelial to mesenchymal transition	TAS		14679171
GO:0007155	cell adhesion	IEA		-
GO:0006350	transcription	IEA		-
GO:0030521	androgen receptor signaling pathway	NAS		15572661
GO:0045893	positive regulation of transcription, DNA-dependent	NAS		15572661
GO:0060070	Wnt receptor signaling pathway through beta-catenin	IC		9601641
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005829	cytosol	EXP		11955436 \|12000790 \|12820959 \|15327769 \|16753179
GO:0005856	cytoskeleton	TAS		7806582
GO:0005634	nucleus	TAS		9065401
GO:0005737	cytoplasm	IEA		-
GO:0005886	plasma membrane	TAS		10837025
GO:0016328	lateral plasma membrane	IDA		12072559
GO:0030877	beta-catenin destruction complex	IDA		9601641 \|16188939

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
ACP1	HAAP \| MGC111030 \| MGC3499	acid phosphatase 1, soluble	-	HPRD,BioGRID	12438242
AJAP1	MOT8 \| RP3-426F10.1 \| SHREW-1 \| SHREW1	adherens junctions associated protein 1	-	HPRD,BioGRID	14595118
APC	BTPS2 \| DP2 \| DP2.5 \| DP3 \| GS	adenomatous polyposis coli	APC interacts with Beta-catenin.	BIND	15525529
APC	BTPS2 \| DP2 \| DP2.5 \| DP3 \| GS	adenomatous polyposis coli	-	HPRD	12000790
APC	BTPS2 \| DP2 \| DP2.5 \| DP3 \| GS	adenomatous polyposis coli	Beta-catenin interacts with APC. This interaction was modelled on a demonstrated interaction between human beta-catenin and mouse Apc.	BIND	15294866
APC	BTPS2 \| DP2 \| DP2.5 \| DP3 \| GS	adenomatous polyposis coli	Affinity Capture-Western Co-crystal Structure Far Western Reconstituted Complex	BioGRID	8259519 \|9286858 \|11251183 \|11533658 \|11707392 \|11712088 \|11972058 \|12628243
APC2	APCL	adenomatosis polyposis coli 2	-	HPRD,BioGRID	9823329 \|10021369
AR	AIS \| DHTR \| HUMARA \| KD \| NR3C4 \| SBMA \| SMAX1 \| TFM	androgen receptor	-	HPRD,BioGRID	11916967
ARHGEF4	ASEF \| ASEF1 \| GEF4 \| STM6	Rho guanine nucleotide exchange factor (GEF) 4	-	HPRD	10947987
AXIN1	AXIN \| MGC52315	axin 1	Affinity Capture-Western Reconstituted Complex Two-hybrid	BioGRID	9734785 \|12805222
AXIN1	AXIN \| MGC52315	axin 1	-	HPRD	12000790
AXIN2	AXIL \| DKFZp781B0869 \| MGC10366 \| MGC126582	axin 2	-	HPRD,BioGRID	10966653
AXIN2	AXIL \| DKFZp781B0869 \| MGC10366 \| MGC126582	axin 2	beta-catenin interacts with the Axin2 promoter.	BIND	15304487
BCL3	BCL4 \| D19S37	B-cell CLL/lymphoma 3	CTNNB1 (beta-catenin) interacts with BCL3.	BIND	15829968
BCL9	LGS \| MGC131591	B-cell CLL/lymphoma 9	Beta-catenin interacts with LGS1.	BIND	15294866
BOC	-	Boc homolog (mouse)	-	HPRD,BioGRID	12634428
BTRC	BETA-TRCP \| FBW1A \| FBXW1 \| FBXW1A \| FWD1 \| MGC4643 \| bTrCP \| bTrCP1 \| betaTrCP	beta-transducin repeat containing	-	HPRD	11818547 \|12114015
BTRC	BETA-TRCP \| FBW1A \| FBXW1 \| FBXW1A \| FWD1 \| MGC4643 \| bTrCP \| bTrCP1 \| betaTrCP	beta-transducin repeat containing	BTRC (Beta-TrCP1) interacts with CTNNB1 (Beta-catenin).	BIND	15735746
CA9	CAIX \| MN	carbonic anhydrase IX	-	HPRD,BioGRID	14567991
CACYBP	GIG5 \| MGC87971 \| PNAS-107 \| RP1-102G20.6 \| S100A6BP \| SIP	calcyclin binding protein	Affinity Capture-Western	BioGRID	11389839
CASP3	CPP32 \| CPP32B \| SCA-1	caspase 3, apoptosis-related cysteine peptidase	-	HPRD	9348292
CASP8	ALPS2B \| CAP4 \| FLICE \| FLJ17672 \| MACH \| MCH5 \| MGC78473	caspase 8, apoptosis-related cysteine peptidase	-	HPRD	12189238
CBY1	C22orf2 \| CBY \| HS508I15A \| PGEA1 \| PIGEA-14 \| PIGEA14 \| arb1	chibby homolog 1 (Drosophila)	-	HPRD,BioGRID	12712206
CCND1	BCL1 \| D11S287E \| PRAD1 \| U21B31	cyclin D1	CTNNB1 (beta-catenin) interacts with the CCND1 promoter.	BIND	15592430
CCND1	BCL1 \| D11S287E \| PRAD1 \| U21B31	cyclin D1	-	HPRD	11836555
CD82	4F9 \| C33 \| GR15 \| IA4 \| KAI1 \| R2 \| SAR2 \| ST6 \| TSPAN27	CD82 molecule	CTNNB1 (beta-catenin) interacts with the CD82 (KAI1) promoter.	BIND	15829968
CDH1	Arc-1 \| CD324 \| CDHE \| ECAD \| LCAM \| UVO	cadherin 1, type 1, E-cadherin (epithelial)	Affinity Capture-Western Co-crystal Structure	BioGRID	7542250 \|7876318 \|7954478 \|8227214 \|9233779 \|9405455 \|9535896 \|9819408 \|10381631 \|10772923 \|11113628 \|11245482 \|11254878 \|11348595 \|11712088 \|11960376 \|12061792 \|12169098 \|12634428 \|12640114 \|12830000 \|15023525
CDH1	Arc-1 \| CD324 \| CDHE \| ECAD \| LCAM \| UVO	cadherin 1, type 1, E-cadherin (epithelial)	-	HPRD	9512503
CDH1	Arc-1 \| CD324 \| CDHE \| ECAD \| LCAM \| UVO	cadherin 1, type 1, E-cadherin (epithelial)	Beta-catenin interacts with E-cadherin. This interaction was modelled on a demonstrated interaction between human beta-catenin and mouse E-cadherin.	BIND	15294866
CDH1	Arc-1 \| CD324 \| CDHE \| ECAD \| LCAM \| UVO	cadherin 1, type 1, E-cadherin (epithelial)	E-cadherin interacts with beta-catenin.	BIND	14706341
CDH1	Arc-1 \| CD324 \| CDHE \| ECAD \| LCAM \| UVO	cadherin 1, type 1, E-cadherin (epithelial)	Beta-catenin interacts with E-cadherin. This interaction was modelled on a demonstrated interaction between beta-catenin from an unspecified species and human E-cadherin.	BIND	15542433
CDH10	-	cadherin 10, type 2 (T2-cadherin)	Affinity Capture-Western	BioGRID	10861224
CDH11	CAD11 \| CDHOB \| OB \| OSF-4	cadherin 11, type 2, OB-cadherin (osteoblast)	-	HPRD,BioGRID	10029089
CDH15	CDH14 \| CDH3 \| CDHM \| MCAD	cadherin 15, type 1, M-cadherin (myotubule)	-	HPRD	9545347
CDH16	-	cadherin 16, KSP-cadherin	-	HPRD	15023525
CDH17	CDH16 \| FLJ26931 \| HPT-1 \| HPT1 \| MGC138218 \| MGC142024	cadherin 17, LI cadherin (liver-intestine)	Affinity Capture-Western	BioGRID	15023525
CDH18	CDH14 \| CDH14L \| CDH24 \| EY-CADHERIN	cadherin 18, type 2	Affinity Capture-Western	BioGRID	10207020
CDH2	CD325 \| CDHN \| CDw325 \| NCAD	cadherin 2, type 1, N-cadherin (neuronal)	Affinity Capture-MS Affinity Capture-Western	BioGRID	12604612 \|14625392
CDH2	CD325 \| CDHN \| CDw325 \| NCAD	cadherin 2, type 1, N-cadherin (neuronal)	-	HPRD	12151522
CDH24	CDH11L \| FLJ25193 \| MGC131880	cadherin-like 24	-	HPRD	12734196
CDH3	CDHP \| HJMD \| PCAD	cadherin 3, type 1, P-cadherin (placental)	-	HPRD	8227214 \|10381631 \|11889072 \|12800191
CDH3	CDHP \| HJMD \| PCAD	cadherin 3, type 1, P-cadherin (placental)	Affinity Capture-Western Co-purification	BioGRID	10381631 \|10910767
CDH5	7B4 \| CD144 \| FLJ17376	cadherin 5, type 2 (vascular endothelium)	-	HPRD	12413882
CDH5	7B4 \| CD144 \| FLJ17376	cadherin 5, type 2 (vascular endothelium)	Affinity Capture-Western	BioGRID	9434630 \|12003790
CDH6	KCAD	cadherin 6, type 2, K-cadherin (fetal kidney)	Affinity Capture-Western	BioGRID	10207020
CDH7	CDH7L1	cadherin 7, type 2	-	HPRD,BioGRID	10861224
CDH8	Nbla04261	cadherin 8, type 2	-	HPRD,BioGRID	9521872
CDH9	MGC125386	cadherin 9, type 2 (T1-cadherin)	-	HPRD,BioGRID	10861224
CDK5	PSSALRE	cyclin-dependent kinase 5	-	HPRD	11168528
CDK5R1	CDK5P35 \| CDK5R \| MGC33831 \| NCK5A \| p23 \| p25 \| p35 \| p35nck5a	cyclin-dependent kinase 5, regulatory subunit 1 (p35)	Affinity Capture-Western Reconstituted Complex	BioGRID	11168528
CDON	CDO \| MGC111524 \| ORCAM	Cdon homolog (mouse)	-	HPRD,BioGRID	12634428
CEBPA	C/EBP-alpha \| CEBP	CCAAT/enhancer binding protein (C/EBP), alpha	-	HPRD,BioGRID	12861022
CHUK	IKBKA \| IKK-alpha \| IKK1 \| IKKA \| NFKBIKA \| TCF16	conserved helix-loop-helix ubiquitous kinase	-	HPRD,BioGRID	11527961
CREBBP	CBP \| KAT3A \| RSTS	CREB binding protein	Phenotypic Enhancement	BioGRID	15782138
CSNK2A1	CK2A1 \| CKII	casein kinase 2, alpha 1 polypeptide	-	HPRD	12432063
CTNNA1	CAP102 \| FLJ36832	catenin (cadherin-associated protein), alpha 1, 102kDa	-	HPRD,BioGRID	7706414
CTNNA1	CAP102 \| FLJ36832	catenin (cadherin-associated protein), alpha 1, 102kDa	Beta-catenin interacts with alpha-catenin. This interaction was modelled on a demonstrated interaction between human beta-catenin and mouse alpha-catenin.	BIND	15294866
CTNNA3	MGC26194 \| MGC75041 \| VR22	catenin (cadherin-associated protein), alpha 3	-	HPRD,BioGRID	11590244
CTNNBIP1	ICAT \| MGC15093	catenin, beta interacting protein 1	-	HPRD,BioGRID	10898789
CTNND1	CAS \| CTNND \| KIAA0384 \| P120CAS \| P120CTN \| p120	catenin (cadherin-associated protein), delta 1	Affinity Capture-Western	BioGRID	9535896 \|11712088
DKK1	DKK-1 \| SK	dickkopf homolog 1 (Xenopus laevis)	CTNNB1 (beta-catenin) interacts with the DKK1 promoter.	BIND	15592430
DLG1	DKFZp761P0818 \| DKFZp781B0426 \| DLGH1 \| SAP97 \| dJ1061C18.1.1 \| hdlg	discs, large homolog 1 (Drosophila)	-	HPRD	9512503
DLG5	KIAA0583 \| LP-DLG \| P-DLG5 \| PDLG	discs, large homolog 5 (Drosophila)	-	HPRD,BioGRID	12657639
DLGAP1	DAP-1 \| DAP-1-ALPHA \| DAP-1-BETA \| GKAP \| MGC88156 \| SAPAP1 \| hGKAP	discs, large (Drosophila) homolog-associated protein 1	Affinity Capture-Western	BioGRID	9286858
DSC3	CDHF3 \| DSC \| DSC1 \| DSC2 \| DSC4 \| HT-CP	desmocollin 3	-	HPRD,BioGRID	10769211
DVL1	DVL \| MGC54245	dishevelled, dsh homolog 1 (Drosophila)	-	HPRD,BioGRID	10806215
DVL2	-	dishevelled, dsh homolog 2 (Drosophila)	Affinity Capture-Western	BioGRID	10806215
DVL3	KIAA0208	dishevelled, dsh homolog 3 (Drosophila)	-	HPRD,BioGRID	10806215
EGFR	ERBB \| ERBB1 \| HER1 \| PIG61 \| mENA	epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)	-	HPRD,BioGRID	9233779
ERBB2	CD340 \| HER-2 \| HER-2/neu \| HER2 \| NEU \| NGL \| TKR1	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	-	HPRD,BioGRID	7702605
ESR1	DKFZp686N23123 \| ER \| ESR \| ESRA \| Era \| NR3A1	estrogen receptor 1	Affinity Capture-Western	BioGRID	15304487
ESR1	DKFZp686N23123 \| ER \| ESR \| ESRA \| Era \| NR3A1	estrogen receptor 1	beta-catenin interacts with ER-alpha.	BIND	15304487
EZR	CVIL \| CVL \| DKFZp762H157 \| FLJ26216 \| MGC1584 \| VIL2	ezrin	-	HPRD,BioGRID	10462524
FAS	ALPS1A \| APO-1 \| APT1 \| CD95 \| FAS1 \| FASTM \| TNFRSF6	Fas (TNF receptor superfamily, member 6)	CTNNB1 (beta-catenin) interacts with the FAS promoter.	BIND	15829968
FER	TYK3	fer (fps/fes related) tyrosine kinase	Biochemical Activity	BioGRID	12640114
FGF20	-	fibroblast growth factor 20	CTNNB1 (beta-catenin) interacts with the FGF20 promoter.	BIND	15592430
FHL2	AAG11 \| DRAL \| SLIM3	four and a half LIM domains 2	-	HPRD,BioGRID	12466281
FOXO1	FKH1 \| FKHR \| FOXO1A	forkhead box O1	beta-catenin interacts with FOXO1. This interaction was modelled on a demonstrated interaction between beta-catenin from an unspecified species and human FOXO1.	BIND	15905404
FOXO3	AF6q21 \| DKFZp781A0677 \| FKHRL1 \| FKHRL1P2 \| FOXO2 \| FOXO3A \| MGC12739 \| MGC31925	forkhead box O3	beta-catenin interacts with FOXO3a.	BIND	15905404
FOXO4	AFX \| AFX1 \| MGC120490 \| MLLT7	forkhead box O4	beta-catenin interacts with FOXO4. This interaction was modelled on a demonstrated interaction between human FOXO4 and beta-catenin from an unspecified species.	BIND	15905404
FSCN2	RFSN \| RP30	fascin homolog 2, actin-bundling protein, retinal (Strongylocentrotus purpuratus)	-	HPRD	11795941
FYN	MGC45350 \| SLK \| SYN	FYN oncogene related to SRC, FGR, YES	Biochemical Activity	BioGRID	12640114
GNA13	G13 \| MGC46138	guanine nucleotide binding protein (G protein), alpha 13	-	HPRD	11136230
GRIK2	EAA4 \| GLR6 \| GLUK6 \| GLUR6 \| MGC74427 \| MRT6	glutamate receptor, ionotropic, kainate 2	-	HPRD	12151522
GRIN1	NMDA1 \| NMDAR1 \| NR1	glutamate receptor, ionotropic, N-methyl D-aspartate 1	-	HPRD	10862698
GSK3B	-	glycogen synthase kinase 3 beta	GSK3B (GSK3-Beta) interacts with and phosphorylates CTNNB1 (Beta-catenin).	BIND	15829978
GSK3B	-	glycogen synthase kinase 3 beta	Affinity Capture-Western Biochemical Activity	BioGRID	10330181 \|11251183
HNF1A	HNF1 \| LFB1 \| MODY3 \| TCF1	HNF1 homeobox A	-	HPRD	11266540 \|12107263
HNF4A	FLJ39654 \| HNF4 \| HNF4a7 \| HNF4a8 \| HNF4a9 \| MODY \| MODY1 \| NR2A1 \| NR2A21 \| TCF \| TCF14	hepatocyte nuclear factor 4, alpha	Affinity Capture-Western Reconstituted Complex	BioGRID	12944908
IGFBP2	IBP2 \| IGF-BP53	insulin-like growth factor binding protein 2, 36kDa	CTNNB1 (beta-catenin) interacts with the IGFBP2 promoter.	BIND	15735679
IKBKB	FLJ40509 \| IKK-beta \| IKK2 \| IKKB \| MGC131801 \| NFKBIKB	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta	-	HPRD,BioGRID	11527961
IQGAP1	HUMORFA01 \| KIAA0051 \| SAR1 \| p195	IQ motif containing GTPase activating protein 1	-	HPRD,BioGRID	11734550\|12446675
JUP	ARVD12 \| CTNNG \| DP3 \| DPIII \| PDGB \| PKGB	junction plakoglobin	Affinity Capture-Western	BioGRID	9535896 \|11712088
KLK3	APS \| KLK2A1 \| PSA \| hK3	kallikrein-related peptidase 3	CTNNB1 (beta-catenin) interacts with the KLK3 (PSA) promoter.	BIND	15829968
LEF1	DKFZp586H0919 \| TCF1ALPHA	lymphoid enhancer-binding factor 1	-	HPRD	8757136 \|12556497
LEF1	DKFZp586H0919 \| TCF1ALPHA	lymphoid enhancer-binding factor 1	Affinity Capture-Western Two-hybrid	BioGRID	8757136 \|12748295 \|15684397
LEF1	DKFZp586H0919 \| TCF1ALPHA	lymphoid enhancer-binding factor 1	LEF-1 interacts with Beta-catenin. This interaction was modeled on a demonstrated interaction between human LEF-1 and mouse Beta-catenin.	BIND	15525529
LGALS9	HUAT \| LGALS9A \| MGC117375 \| MGC125973 \| MGC125974	lectin, galactoside-binding, soluble, 9	Affinity Capture-MS	BioGRID	17353931
MAGI1	AIP3 \| BAIAP1 \| BAP1 \| MAGI-1 \| TNRC19 \| WWP3	membrane associated guanylate kinase, WW and PDZ domain containing 1	Affinity Capture-Western Reconstituted Complex Two-hybrid	BioGRID	10772923
MAGI2	ACVRIP1 \| AIP1 \| ARIP1 \| MAGI-2 \| SSCAM	membrane associated guanylate kinase, WW and PDZ domain containing 2	-	HPRD	11826105
MET	AUTS9 \| HGFR \| RCCP2 \| c-Met	met proto-oncogene (hepatocyte growth factor receptor)	Affinity Capture-Western	BioGRID	11254878
MUC1	CD227 \| EMA \| H23AG \| MAM6 \| PEM \| PEMT \| PUM	mucin 1, cell surface associated	Affinity Capture-Western Reconstituted Complex	BioGRID	9139698 \|9819408 \|11152665 \|11483589 \|11877440 \|12618757 \|12750561
MUC1	CD227 \| EMA \| H23AG \| MAM6 \| PEM \| PEMT \| PUM	mucin 1, cell surface associated	MUC1 interacts with beta-catenin.	BIND	11483589
MUC1	CD227 \| EMA \| H23AG \| MAM6 \| PEM \| PEMT \| PUM	mucin 1, cell surface associated	-	HPRD	9139698 \|11152665 \|11483589 \|11877440
MYO7A	DFNA11 \| DFNB2 \| MYOVIIA \| MYU7A \| NSRD2 \| USH1B	myosin VIIA	Affinity Capture-Western	BioGRID	11080149
NEURL2	C20orf163 \| MGC125934 \| MGC125935 \| OZZ \| Ozz-E3	neuralized homolog 2 (Drosophila)	-	HPRD	14960280
NFKB1	DKFZp686C01211 \| EBP-1 \| KBF1 \| MGC54151 \| NF-kappa-B \| NFKB-p105 \| NFKB-p50 \| p105	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	NFKB1 (p50) interacts with CTNNB1 (beta-catenin).	BIND	15829968
NLK	DKFZp761G1211 \| FLJ21033	nemo-like kinase	Affinity Capture-Western	BioGRID	12556497
NR5A1	AD4BP \| ELP \| FTZ1 \| FTZF1 \| SF-1 \| SF1	nuclear receptor subfamily 5, group A, member 1	-	HPRD,BioGRID	12554773
NR5A2	B1F \| B1F2 \| CPF \| FTF \| FTZ-F1 \| FTZ-F1beta \| LRH-1 \| hB1F \| hB1F-2	nuclear receptor subfamily 5, group A, member 2	beta-catenin interacts with LRH-1.	BIND	15327767
PCSK1	BMIQ12 \| NEC1 \| PC1 \| PC3 \| SPC3	proprotein convertase subtilisin/kexin type 1	Affinity Capture-Western	BioGRID	11113628
PECAM1	CD31 \| PECAM-1	platelet/endothelial cell adhesion molecule	-	HPRD,BioGRID	10801826
PHB2	BAP \| BCAP37 \| Bap37 \| MGC117268 \| PNAS-141 \| REA \| p22	prohibitin 2	Affinity Capture-MS	BioGRID	17353931
PIK3R1	GRB1 \| p85 \| p85-ALPHA	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	Reconstituted Complex	BioGRID	10477752
PIK3R1	GRB1 \| p85 \| p85-ALPHA	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	-	HPRD	11716761
PIN1	DOD \| UBL5	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	-	HPRD,BioGRID	11533658
PKD1	PBP	polycystic kidney disease 1 (autosomal dominant)	Polycystin-1 interacts with beta-catenin.	BIND	11113628
PKD1	PBP	polycystic kidney disease 1 (autosomal dominant)	-	HPRD	11274246
PKP2	ARVD9	plakophilin 2	-	HPRD	11790773
PSEN1	AD3 \| FAD \| PS1 \| S182	presenilin 1	Affinity Capture-Western	BioGRID	9738936 \|9852041 \|10341227
PSEN1	AD3 \| FAD \| PS1 \| S182	presenilin 1	PS1 interacts with beta-catenin.	BIND	9632714
PTN	HARP \| HBGF8 \| HBNF \| NEGF1	pleiotrophin	Affinity Capture-Western	BioGRID	10706604
PTPN1	PTP1B	protein tyrosine phosphatase, non-receptor type 1	-	HPRD,BioGRID	12377785
PTPN11	BPTP3 \| CFC \| MGC14433 \| NS1 \| PTP-1D \| PTP2C \| SH-PTP2 \| SH-PTP3 \| SHP2	protein tyrosine phosphatase, non-receptor type 11	Affinity Capture-Western	BioGRID	10681592
PTPN13	DKFZp686J1497 \| FAP-1 \| PNP1 \| PTP-BAS \| PTP-BL \| PTP1E \| PTPL1 \| PTPLE	protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)	Reconstituted Complex	BioGRID	10951583
PTPN14	MGC126803 \| PEZ \| PTP36	protein tyrosine phosphatase, non-receptor type 14	-	HPRD,BioGRID	12808048
PTPRB	DKFZp686E2262 \| DKFZp686H15164 \| FLJ44133 \| HPTP-BETA \| HPTPB \| MGC142023 \| MGC59935 \| PTPB \| R-PTP-BETA \| VEPTP	protein tyrosine phosphatase, receptor type, B	-	HPRD	10706604
PTPRF	FLJ43335 \| FLJ45062 \| FLJ45567 \| LAR	protein tyrosine phosphatase, receptor type, F	Affinity Capture-Western Reconstituted Complex	BioGRID	9245795 \|11245482
PTPRF	FLJ43335 \| FLJ45062 \| FLJ45567 \| LAR	protein tyrosine phosphatase, receptor type, F	-	HPRD	9245795 \|12095414
PTPRJ	CD148 \| DEP1 \| HPTPeta \| R-PTP-ETA \| SCC1	protein tyrosine phosphatase, receptor type, J	-	HPRD,BioGRID	12370829
PTPRK	DKFZp686C2268 \| DKFZp779N1045 \| R-PTP-kappa	protein tyrosine phosphatase, receptor type, K	-	HPRD,BioGRID	8663237
PTPRU	FLJ37530 \| FMI \| GLEPP1 \| PCP-2 \| PTP \| PTP-J \| PTP-PI \| PTPPSI \| PTPRO \| PTPU2 \| R-PTP-PSI \| hPTP-J	protein tyrosine phosphatase, receptor type, U	-	HPRD,BioGRID	12501215
PTPRZ1	HPTPZ \| HPTPzeta \| PTP-ZETA \| PTP18 \| PTPRZ \| PTPZ \| RPTPB \| RPTPbeta \| phosphacan	protein tyrosine phosphatase, receptor-type, Z polypeptide 1	-	HPRD,BioGRID	10706604
PYGO1	DKFZp547G0910	pygopus homolog 1 (Drosophila)	-	HPRD	11955446
RAB8B	FLJ38125	RAB8B, member RAS oncogene family	Affinity Capture-Western	BioGRID	12639940
RICS	GC-GAP \| GRIT \| KIAA0712 \| MGC1892 \| p200RhoGAP \| p250GAP	Rho GTPase-activating protein	-	HPRD	12531901
RUVBL1	ECP54 \| INO80H \| NMP238 \| PONTIN \| Pontin52 \| RVB1 \| TIH1 \| TIP49 \| TIP49A	RuvB-like 1 (E. coli)	Affinity Capture-Western Reconstituted Complex	BioGRID	9843967
RUVBL2	CGI-46 \| ECP51 \| INO80J \| REPTIN \| RVB2 \| TIH2 \| TIP48 \| TIP49B	RuvB-like 2 (E. coli)	CTNNB1 (beta-catenin) interacts with RUVBL2 (reptin).	BIND	15829968
RXRA	FLJ00280 \| FLJ00318 \| FLJ16020 \| FLJ16733 \| MGC102720 \| NR2B1	retinoid X receptor, alpha	Affinity Capture-Western	BioGRID	12771132
SGK1	SGK	serum/glucocorticoid regulated kinase 1	CTNNB1 (beta-catenin) interacts with the SGK promoter.	BIND	15735679
SKP1	EMC19 \| MGC34403 \| OCP-II \| OCP2 \| SKP1A \| TCEB1L \| p19A	S-phase kinase-associated protein 1	Affinity Capture-Western	BioGRID	11389839
SLC9A3R1	EBP50 \| NHERF \| NHERF1 \| NPHLOP2	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1	-	HPRD,BioGRID	12830000
SMAD2	JV18 \| JV18-1 \| MADH2 \| MADR2 \| MGC22139 \| MGC34440 \| hMAD-2 \| hSMAD2	SMAD family member 2	-	HPRD,BioGRID	12000714
SMAD3	DKFZp586N0721 \| DKFZp686J10186 \| HSPC193 \| HsT17436 \| JV15-2 \| MADH3 \| MGC60396	SMAD family member 3	-	HPRD,BioGRID	12000714
SMAD4	DPC4 \| JIP \| MADH4	SMAD family member 4	-	HPRD,BioGRID	12000714
SMAD7	CRCS3 \| FLJ16482 \| MADH7 \| MADH8	SMAD family member 7	Affinity Capture-Western Co-localization	BioGRID	15684397
SMARCA4	BAF190 \| BRG1 \| FLJ39786 \| SNF2 \| SNF2-BETA \| SNF2L4 \| SNF2LB \| SWI2 \| hSNF2b	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	-	HPRD,BioGRID	11532957
TAX1BP3	TIP-1	Tax1 (human T-cell leukemia virus type I) binding protein 3	-	HPRD	12874278
TBL1X	EBI \| SMAP55 \| TBL1	transducin (beta)-like 1X-linked	-	HPRD,BioGRID	11389839
TCF3	E2A \| ITF1 \| MGC129647 \| MGC129648 \| bHLHb21	transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)	-	HPRD	12107263
TCF4	E2-2 \| ITF2 \| MGC149723 \| MGC149724 \| PTHS \| SEF2 \| SEF2-1 \| SEF2-1A \| SEF2-1B \| bHLHb19	transcription factor 4	-	HPRD	11713476\|12861022
TCF4	E2-2 \| ITF2 \| MGC149723 \| MGC149724 \| PTHS \| SEF2 \| SEF2-1 \| SEF2-1A \| SEF2-1B \| bHLHb19	transcription factor 4	Affinity Capture-Western Co-crystal Structure Reconstituted Complex	BioGRID	11713475 \|11713476 \|12657632 \|15331612
TCF7L1	TCF-3 \| TCF3	transcription factor 7-like 1 (T-cell specific, HMG-box)	Co-crystal Structure	BioGRID	11136974
TCF7L1	TCF-3 \| TCF3	transcription factor 7-like 1 (T-cell specific, HMG-box)	-	HPRD	11266540
TCF7L2	TCF-4 \| TCF4	transcription factor 7-like 2 (T-cell specific, HMG-box)	Affinity Capture-Western	BioGRID	12861022
TCF7L2	TCF-4 \| TCF4	transcription factor 7-like 2 (T-cell specific, HMG-box)	-	HPRD	11713476
TCF7L2	TCF-4 \| TCF4	transcription factor 7-like 2 (T-cell specific, HMG-box)	TCF-4 interacts with Beta-catenin.	BIND	15525529
TCF7L2	TCF-4 \| TCF4	transcription factor 7-like 2 (T-cell specific, HMG-box)	Beta-catenin interacts with TCF4.	BIND	15294866
TFAP2A	AP-2 \| AP-2alpha \| AP2TF \| BOFS \| TFAP2	transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)	Affinity Capture-Western	BioGRID	15331612
TFF1	BCEI \| D21S21 \| HP1.A \| HPS2 \| pNR-2 \| pS2	trefoil factor 1	beta-catenin interacts with the pS2 promoter.	BIND	15304487
TGFBR1	AAT5 \| ACVRLK4 \| ALK-5 \| ALK5 \| LDS1A \| LDS2A \| SKR4 \| TGFR-1	transforming growth factor, beta receptor 1	-	HPRD	12000714
TGFBR2	AAT3 \| FAA3 \| LDS1B \| LDS2B \| MFS2 \| RIIC \| TAAD2 \| TGFR-2 \| TGFbeta-RII	transforming growth factor, beta receptor II (70/80kDa)	Affinity Capture-Western	BioGRID	12000714
USP9X	DFFRX \| FAF \| FAM	ubiquitin specific peptidase 9, X-linked	-	HPRD,BioGRID	10620020
VCL	CMD1W \| MVCL	vinculin	Affinity Capture-Western	BioGRID	9405455
VEZT	DKFZp761C241 \| VEZATIN	vezatin, adherens junctions transmembrane protein	-	HPRD,BioGRID	11080149

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
KEGG WNT SIGNALING PATHWAY	151	112	All SZGR 2.0 genes in this pathway
KEGG FOCAL ADHESION	201	138	All SZGR 2.0 genes in this pathway
KEGG ADHERENS JUNCTION	75	53	All SZGR 2.0 genes in this pathway
KEGG TIGHT JUNCTION	134	86	All SZGR 2.0 genes in this pathway
KEGG LEUKOCYTE TRANSENDOTHELIAL MIGRATION	118	78	All SZGR 2.0 genes in this pathway
KEGG MELANOGENESIS	102	80	All SZGR 2.0 genes in this pathway
KEGG PATHOGENIC ESCHERICHIA COLI INFECTION	59	36	All SZGR 2.0 genes in this pathway
KEGG PATHWAYS IN CANCER	328	259	All SZGR 2.0 genes in this pathway
KEGG COLORECTAL CANCER	62	47	All SZGR 2.0 genes in this pathway
KEGG ENDOMETRIAL CANCER	52	45	All SZGR 2.0 genes in this pathway
KEGG PROSTATE CANCER	89	75	All SZGR 2.0 genes in this pathway
KEGG THYROID CANCER	29	26	All SZGR 2.0 genes in this pathway
KEGG BASAL CELL CARCINOMA	55	44	All SZGR 2.0 genes in this pathway
KEGG ARRHYTHMOGENIC RIGHT VENTRICULAR CARDIOMYOPATHY ARVC	76	59	All SZGR 2.0 genes in this pathway
BIOCARTA ALK PATHWAY	37	29	All SZGR 2.0 genes in this pathway
BIOCARTA CELL2CELL PATHWAY	14	11	All SZGR 2.0 genes in this pathway
BIOCARTA GSK3 PATHWAY	27	26	All SZGR 2.0 genes in this pathway
BIOCARTA PITX2 PATHWAY	15	15	All SZGR 2.0 genes in this pathway
BIOCARTA PS1 PATHWAY	14	14	All SZGR 2.0 genes in this pathway
BIOCARTA TFF PATHWAY	21	15	All SZGR 2.0 genes in this pathway
BIOCARTA WNT PATHWAY	26	24	All SZGR 2.0 genes in this pathway
WNT SIGNALING	89	71	All SZGR 2.0 genes in this pathway
ST WNT BETA CATENIN PATHWAY	34	28	All SZGR 2.0 genes in this pathway
PID BETA CATENIN DEG PATHWAY	18	17	All SZGR 2.0 genes in this pathway
PID MET PATHWAY	80	60	All SZGR 2.0 genes in this pathway
PID AR PATHWAY	61	46	All SZGR 2.0 genes in this pathway
PID ARF6 TRAFFICKING PATHWAY	49	34	All SZGR 2.0 genes in this pathway
PID PS1 PATHWAY	46	39	All SZGR 2.0 genes in this pathway
PID ILK PATHWAY	45	32	All SZGR 2.0 genes in this pathway
PID NECTIN PATHWAY	30	20	All SZGR 2.0 genes in this pathway
PID CDC42 PATHWAY	70	51	All SZGR 2.0 genes in this pathway
PID WNT CANONICAL PATHWAY	20	18	All SZGR 2.0 genes in this pathway
PID FOXO PATHWAY	49	43	All SZGR 2.0 genes in this pathway
PID AJDISS 2PATHWAY	48	38	All SZGR 2.0 genes in this pathway
PID ECADHERIN NASCENT AJ PATHWAY	39	33	All SZGR 2.0 genes in this pathway
PID AP1 PATHWAY	70	60	All SZGR 2.0 genes in this pathway
PID ECADHERIN KERATINOCYTE PATHWAY	21	19	All SZGR 2.0 genes in this pathway
PID BETA CATENIN NUC PATHWAY	80	60	All SZGR 2.0 genes in this pathway
PID ECADHERIN STABILIZATION PATHWAY	42	34	All SZGR 2.0 genes in this pathway
PID VEGFR1 2 PATHWAY	69	57	All SZGR 2.0 genes in this pathway
PID NCADHERIN PATHWAY	33	32	All SZGR 2.0 genes in this pathway
PID RAC1 PATHWAY	54	37	All SZGR 2.0 genes in this pathway
PID TGFBR PATHWAY	55	38	All SZGR 2.0 genes in this pathway
REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS	40	26	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY WNT	65	41	All SZGR 2.0 genes in this pathway
REACTOME CTNNB1 PHOSPHORYLATION CASCADE	16	11	All SZGR 2.0 genes in this pathway
REACTOME DEVELOPMENTAL BIOLOGY	396	292	All SZGR 2.0 genes in this pathway
REACTOME CELL CELL COMMUNICATION	120	77	All SZGR 2.0 genes in this pathway
REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS	12	6	All SZGR 2.0 genes in this pathway
REACTOME INTEGRATION OF ENERGY METABOLISM	120	84	All SZGR 2.0 genes in this pathway
REACTOME REGULATION OF INSULIN SECRETION	93	65	All SZGR 2.0 genes in this pathway
REACTOME ADHERENS JUNCTIONS INTERACTIONS	27	20	All SZGR 2.0 genes in this pathway
REACTOME CELL CELL JUNCTION ORGANIZATION	56	31	All SZGR 2.0 genes in this pathway
REACTOME CELL JUNCTION ORGANIZATION	78	43	All SZGR 2.0 genes in this pathway
REACTOME MYOGENESIS	28	20	All SZGR 2.0 genes in this pathway
REACTOME INCRETIN SYNTHESIS SECRETION AND INACTIVATION	22	14	All SZGR 2.0 genes in this pathway
REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GLP1	19	12	All SZGR 2.0 genes in this pathway
REACTOME APOPTOSIS	148	94	All SZGR 2.0 genes in this pathway
REACTOME APOPTOTIC EXECUTION PHASE	54	37	All SZGR 2.0 genes in this pathway
PARENT MTOR SIGNALING UP	567	375	All SZGR 2.0 genes in this pathway
ONKEN UVEAL MELANOMA DN	526	357	All SZGR 2.0 genes in this pathway
WANG LMO4 TARGETS UP	372	227	All SZGR 2.0 genes in this pathway
DITTMER PTHLH TARGETS UP	112	68	All SZGR 2.0 genes in this pathway
KOINUMA COLON CANCER MSI UP	16	11	All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN	1781	1082	All SZGR 2.0 genes in this pathway
HWANG PROSTATE CANCER MARKERS	28	19	All SZGR 2.0 genes in this pathway
LASTOWSKA NEUROBLASTOMA COPY NUMBER DN	800	473	All SZGR 2.0 genes in this pathway
BREUHAHN GROWTH FACTOR SIGNALING IN LIVER CANCER	22	19	All SZGR 2.0 genes in this pathway
SCHEIDEREIT IKK TARGETS	18	15	All SZGR 2.0 genes in this pathway
SCHEIDEREIT IKK INTERACTING PROTEINS	58	45	All SZGR 2.0 genes in this pathway
LOPEZ MBD TARGETS	957	597	All SZGR 2.0 genes in this pathway
COLIN PILOCYTIC ASTROCYTOMA VS GLIOBLASTOMA DN	28	21	All SZGR 2.0 genes in this pathway
GOTZMANN EPITHELIAL TO MESENCHYMAL TRANSITION DN	206	136	All SZGR 2.0 genes in this pathway
AMIT EGF RESPONSE 480 HELA	164	118	All SZGR 2.0 genes in this pathway
MAGRANGEAS MULTIPLE MYELOMA IGLL VS IGLK DN	24	18	All SZGR 2.0 genes in this pathway
CROMER METASTASIS UP	79	46	All SZGR 2.0 genes in this pathway
WEIGEL OXIDATIVE STRESS BY HNE AND H2O2	39	29	All SZGR 2.0 genes in this pathway
VERRECCHIA RESPONSE TO TGFB1 C5	21	11	All SZGR 2.0 genes in this pathway
MA PITUITARY FETAL VS ADULT UP	29	21	All SZGR 2.0 genes in this pathway
VERRECCHIA DELAYED RESPONSE TO TGFB1	39	26	All SZGR 2.0 genes in this pathway
LEE AGING NEOCORTEX UP	89	59	All SZGR 2.0 genes in this pathway
ZHOU TNF SIGNALING 30MIN	54	36	All SZGR 2.0 genes in this pathway
JACKSON DNMT1 TARGETS UP	77	57	All SZGR 2.0 genes in this pathway
HEDENFALK BREAST CANCER BRCA1 VS BRCA2	163	113	All SZGR 2.0 genes in this pathway
JI RESPONSE TO FSH UP	74	56	All SZGR 2.0 genes in this pathway
KYNG RESPONSE TO H2O2	71	42	All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 5	482	296	All SZGR 2.0 genes in this pathway
WALLACE PROSTATE CANCER RACE UP	299	167	All SZGR 2.0 genes in this pathway
HONMA DOCETAXEL RESISTANCE	34	23	All SZGR 2.0 genes in this pathway
GRADE COLON CANCER UP	871	505	All SZGR 2.0 genes in this pathway
GRESHOCK CANCER COPY NUMBER UP	323	240	All SZGR 2.0 genes in this pathway
ZAIDI OSTEOBLAST TRANSCRIPTION FACTORS	14	12	All SZGR 2.0 genes in this pathway
HAN SATB1 TARGETS DN	442	275	All SZGR 2.0 genes in this pathway
HSIAO HOUSEKEEPING GENES	389	245	All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA CHEMOTAXIS DN	457	302	All SZGR 2.0 genes in this pathway
HOSHIDA LIVER CANCER SUBCLASS S2	115	74	All SZGR 2.0 genes in this pathway
NAKAMURA ADIPOGENESIS EARLY UP	66	44	All SZGR 2.0 genes in this pathway
NAKAMURA ADIPOGENESIS LATE UP	104	67	All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 3 DN	918	550	All SZGR 2.0 genes in this pathway
FEVR CTNNB1 TARGETS DN	553	343	All SZGR 2.0 genes in this pathway
KRIEG HYPOXIA NOT VIA KDM3A	770	480	All SZGR 2.0 genes in this pathway
GUILLAUMOND KLF10 TARGETS DN	30	15	All SZGR 2.0 genes in this pathway
RAO BOUND BY SALL4 ISOFORM B	517	302	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-139	349	355	1A	hsa-miR-139^brain	UCUACAGUGCACGUGUCU
miR-141/200a	697	703	1A	hsa-miR-141	UAACACUGUCUGGUAAAGAUGG
miR-141/200a	697	703	1A	hsa-miR-200a	UAACACUGUCUGGUAACGAUGU
miR-217	669	675	1A	hsa-miR-217	UACUGCAUCAGGAACUGAUUGGAU
miR-320	239	245	m8	hsa-miR-320	AAAAGCUGGGUUGAGAGGGCGAA
miR-381	829	835	1A	hsa-miR-381	UAUACAAGGGCAAGCUCUCUGU

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: CTNNB1