SZGR2

Summary ?

GeneID	151
Symbol	ADRA2B
Synonyms	ADRA2L1\|ADRA2RL1\|ADRARL1\|ALPHA2BAR\|FAME2\|alpha-2BAR
Description	adrenoceptor alpha 2B
Reference	MIM:104260\|HGNC:HGNC:282\|Ensembl:ENSG00000274286\|HPRD:00086\|Vega:OTTHUMG00000188276
Gene type	protein-coding
Map location	2q11.1
Pascal p-value	0.042
Fetal beta	-0.347
eGene	Cerebellar Hemisphere Cerebellum Myers' cis & trans

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
ADT:Sun_2012	Systematic Investigation of Antipsychotic Drugs and Their Targets	A total of 382 drug-target associations involving 43 antipsychotic drugs and 49 target genes.
CV:PGCnp	Genome-wide Association Study	GWAS
PMID:cooccur	High-throughput literature-search	Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
GSMA_I	Genome scan meta-analysis	Psr: 0.0004
Literature	High-throughput literature-search	Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenias	Click to show details

Section I. Genetics and epigenetics annotation

eQTL annotation

SNP ID	Chromosome	Position	eGene	Gene Entrez ID	pvalue	qvalue	TSS distance	eQTL type
rs10958910	chr9	10134759	ADRA2B	151		0.18		trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
UNC93B3	0.68	0.68
CXCL16	0.66	0.71
PARP12	0.64	0.68
TNFRSF1A	0.64	0.68
SLC15A3	0.63	0.69
HLA-E	0.62	0.68
LGALS9	0.61	0.69
BAMBI	0.60	0.64
FAH	0.60	0.65
IRF1	0.60	0.65

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
RTF1	-0.51	-0.54
SRPK1	-0.49	-0.51
ANKRD12	-0.49	-0.55
TMEM57	-0.48	-0.49
ZNF714	-0.48	-0.51
MPP3	-0.48	-0.50
KIDINS220	-0.48	-0.47
STMN1	-0.48	-0.53
BZW2	-0.48	-0.53
ZNF91	-0.48	-0.51

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0004872	receptor activity	IEA		-
GO:0004938	alpha2-adrenergic receptor activity	TAS		2164221
GO:0004935	adrenoceptor activity	IEA		-
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0007186	G-protein coupled receptor protein signaling pathway	TAS		2164221
GO:0007267	cell-cell signaling	TAS		2164221
GO:0007165	signal transduction	IEA		-
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005886	plasma membrane	TAS		2164221
GO:0005887	integral to plasma membrane	TAS		2164221

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
KEGG NEUROACTIVE LIGAND RECEPTOR INTERACTION	272	195	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY GPCR	920	449	All SZGR 2.0 genes in this pathway
REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS	305	177	All SZGR 2.0 genes in this pathway
REACTOME AMINE LIGAND BINDING RECEPTORS	38	33	All SZGR 2.0 genes in this pathway
REACTOME GPCR DOWNSTREAM SIGNALING	805	368	All SZGR 2.0 genes in this pathway
REACTOME G ALPHA I SIGNALLING EVENTS	195	114	All SZGR 2.0 genes in this pathway
REACTOME G ALPHA Z SIGNALLING EVENTS	44	29	All SZGR 2.0 genes in this pathway
REACTOME GPCR LIGAND BINDING	408	246	All SZGR 2.0 genes in this pathway
REACTOME PLATELET AGGREGATION PLUG FORMATION	36	23	All SZGR 2.0 genes in this pathway
REACTOME HEMOSTASIS	466	331	All SZGR 2.0 genes in this pathway
REACTOME PLATELET ACTIVATION SIGNALING AND AGGREGATION	208	138	All SZGR 2.0 genes in this pathway
CHIARADONNA NEOPLASTIC TRANSFORMATION CDC25 DN	153	100	All SZGR 2.0 genes in this pathway
SHEN SMARCA2 TARGETS DN	357	212	All SZGR 2.0 genes in this pathway
CHESLER BRAIN D6MIT150 QTL TRANS	9	7	All SZGR 2.0 genes in this pathway
MEISSNER NPC HCP WITH H3K4ME3 AND H3K27ME3	142	103	All SZGR 2.0 genes in this pathway
MEISSNER BRAIN HCP WITH H3K4ME3 AND H3K27ME3	1069	729	All SZGR 2.0 genes in this pathway
HOSHIDA LIVER CANCER LATE RECURRENCE DN	69	48	All SZGR 2.0 genes in this pathway
HOSHIDA LIVER CANCER SURVIVAL DN	113	76	All SZGR 2.0 genes in this pathway
MIKKELSEN NPC HCP WITH H3K4ME3 AND H3K27ME3	210	148	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-139	914	920	1A	hsa-miR-139^brain	UCUACAGUGCACGUGUCU
miR-23	854	860	m8	hsa-miR-23a^brain	AUCACAUUGCCAGGGAUUUCC
miR-23	854	860	m8	hsa-miR-23b^brain	AUCACAUUGCCAGGGAUUACC
miR-30-5p	893	899	m8	hsa-miR-30a-5p	UGUAAACAUCCUCGACUGGAAG
				hsa-miR-30c^brain	UGUAAACAUCCUACACUCUCAGC
				hsa-miR-30d^SZ	UGUAAACAUCCCCGACUGGAAG
				hsa-miR-30b^SZ	UGUAAACAUCCUACACUCAGCU
				hsa-miR-30e-5p	UGUAAACAUCCUUGACUGGA
miR-323	854	860	1A	hsa-miR-323^brain	GCACAUUACACGGUCGACCUCU
miR-329	939	945	m8	hsa-miR-329^brain	AACACACCUGGUUAACCUCUUU
miR-330	816	822	1A	hsa-miR-330^brain	GCAAAGCACACGGCCUGCAGAGA
miR-377	941	948	1A,m8	hsa-miR-377	AUCACACAAAGGCAACUUUUGU

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: ADRA2B