Gene Page: CMTM8
Summary ?
| GeneID | 152189 |
| Symbol | CMTM8 |
| Synonyms | CKLFSF8|CKLFSF8-V2 |
| Description | CKLF like MARVEL transmembrane domain containing 8 |
| Reference | MIM:607891|HGNC:HGNC:19179|Ensembl:ENSG00000170293|HPRD:06989|Vega:OTTHUMG00000130753 |
| Gene type | protein-coding |
| Map location | 3p22.3 |
| Pascal p-value | 0.359 |
| Sherlock p-value | 4.203E-5 |
| DMG | 1 (# studies) |
| eGene | Myers' cis & trans |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:GWASdb | Genome-wide Association Studies | GWASdb records for schizophrenia | |
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DMG:Nishioka_2013 | Genome-wide DNA methylation analysis | The authors investigated the methylation profiles of DNA in peripheral blood cells from 18 patients with first-episode schizophrenia (FESZ) and from 15 normal controls. | 1 |
| GSMA_I | Genome scan meta-analysis | Psr: 0.006 |
Section I. Genetics and epigenetics annotation
Differentially methylated gene
| Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
|---|---|---|---|---|---|---|---|
| cg10553028 | 3 | 32280480 | CMTM8 | -0.024 | 0.36 | DMG:Nishioka_2013 |
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs16865919 | chr2 | 7229169 | CMTM8 | 152189 | 0.01 | trans | ||
| rs7705470 | chr5 | 161882436 | CMTM8 | 152189 | 0.09 | trans | ||
| rs6870265 | chr5 | 161883432 | CMTM8 | 152189 | 0.05 | trans | ||
| rs7830307 | chr8 | 36560734 | CMTM8 | 152189 | 0.01 | trans | ||
| rs2096481 | chr8 | 36570335 | CMTM8 | 152189 | 0 | trans | ||
| rs16885322 | chr8 | 36598931 | CMTM8 | 152189 | 0 | trans | ||
| rs16912226 | chr9 | 27999509 | CMTM8 | 152189 | 0.12 | trans | ||
| rs16936324 | chr10 | 36060904 | CMTM8 | 152189 | 9.089E-4 | trans | ||
| rs17093091 | chr14 | 23954891 | CMTM8 | 152189 | 0.06 | trans |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section III. Gene Ontology annotation
| Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0005125 | cytokine activity | IEA | - | |
| Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0006935 | chemotaxis | IEA | - | |
| Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0005615 | extracellular space | IEA | - | |
| GO:0016020 | membrane | IEA | - | |
| GO:0016021 | integral to membrane | IEA | - |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| LU TUMOR VASCULATURE UP | 29 | 17 | All SZGR 2.0 genes in this pathway |
| TURASHVILI BREAST DUCTAL CARCINOMA VS DUCTAL NORMAL DN | 198 | 110 | All SZGR 2.0 genes in this pathway |
| GARY CD5 TARGETS UP | 473 | 314 | All SZGR 2.0 genes in this pathway |
| DODD NASOPHARYNGEAL CARCINOMA UP | 1821 | 933 | All SZGR 2.0 genes in this pathway |
| LASTOWSKA NEUROBLASTOMA COPY NUMBER DN | 800 | 473 | All SZGR 2.0 genes in this pathway |
| NUYTTEN EZH2 TARGETS DN | 1024 | 594 | All SZGR 2.0 genes in this pathway |
| MEISSNER BRAIN HCP WITH H3K4ME3 AND H3K27ME3 | 1069 | 729 | All SZGR 2.0 genes in this pathway |
| WONG ADULT TISSUE STEM MODULE | 721 | 492 | All SZGR 2.0 genes in this pathway |