Gene Page: ATP6V0E2
Summary ?
| GeneID | 155066 |
| Symbol | ATP6V0E2 |
| Synonyms | ATP6V0E2L|C7orf32 |
| Description | ATPase H+ transporting V0 subunit e2 |
| Reference | MIM:611019|HGNC:HGNC:21723|Ensembl:ENSG00000171130|HPRD:12920|Vega:OTTHUMG00000158094 |
| Gene type | protein-coding |
| Map location | 7q36.1 |
| Pascal p-value | 0.191 |
| Sherlock p-value | 0.538 |
| Fetal beta | -1.116 |
| DMG | 1 (# studies) |
| eGene | Caudate basal ganglia Cerebellar Hemisphere Cerebellum Cortex Frontal Cortex BA9 Hypothalamus Nucleus accumbens basal ganglia Putamen basal ganglia Meta |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DMG:Jaffe_2016 | Genome-wide DNA methylation analysis | This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. | 1 |
Section I. Genetics and epigenetics annotation
Differentially methylated gene
| Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
|---|---|---|---|---|---|---|---|
| cg07531228 | 7 | 149745299 | ATP6V0E2 | 1.77E-9 | -0.012 | 1.53E-6 | DMG:Jaffe_2016 |
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs4725833 | 7 | 149556518 | ATP6V0E2 | ENSG00000171130.13 | 1.015E-8 | 0 | -13539 | gtex_brain_putamen_basal |
| rs2240361 | 7 | 149558409 | ATP6V0E2 | ENSG00000171130.13 | 8.186E-7 | 0 | -11648 | gtex_brain_putamen_basal |
| rs2074700 | 7 | 149559273 | ATP6V0E2 | ENSG00000171130.13 | 4.066E-7 | 0 | -10784 | gtex_brain_putamen_basal |
| rs2074701 | 7 | 149559465 | ATP6V0E2 | ENSG00000171130.13 | 1.578E-6 | 0 | -10592 | gtex_brain_putamen_basal |
| rs2074702 | 7 | 149559839 | ATP6V0E2 | ENSG00000171130.13 | 4.19E-7 | 0 | -10218 | gtex_brain_putamen_basal |
| rs6464035 | 7 | 149560072 | ATP6V0E2 | ENSG00000171130.13 | 1.545E-7 | 0 | -9985 | gtex_brain_putamen_basal |
| rs10270385 | 7 | 149560348 | ATP6V0E2 | ENSG00000171130.13 | 1.578E-6 | 0 | -9709 | gtex_brain_putamen_basal |
| rs2240363 | 7 | 149560785 | ATP6V0E2 | ENSG00000171130.13 | 2.374E-7 | 0 | -9272 | gtex_brain_putamen_basal |
| rs2074703 | 7 | 149560847 | ATP6V0E2 | ENSG00000171130.13 | 6.789E-9 | 0 | -9210 | gtex_brain_putamen_basal |
| rs3857764 | 7 | 149561049 | ATP6V0E2 | ENSG00000171130.13 | 5.448E-9 | 0 | -9008 | gtex_brain_putamen_basal |
| rs1859529 | 7 | 149562285 | ATP6V0E2 | ENSG00000171130.13 | 6.552E-7 | 0 | -7772 | gtex_brain_putamen_basal |
| rs3214231 | 7 | 149562627 | ATP6V0E2 | ENSG00000171130.13 | 4.154E-9 | 0 | -7430 | gtex_brain_putamen_basal |
| rs2373465 | 7 | 149563134 | ATP6V0E2 | ENSG00000171130.13 | 1.968E-8 | 0 | -6923 | gtex_brain_putamen_basal |
| rs3735330 | 7 | 149563738 | ATP6V0E2 | ENSG00000171130.13 | 3.488E-7 | 0 | -6319 | gtex_brain_putamen_basal |
| rs3735331 | 7 | 149564770 | ATP6V0E2 | ENSG00000171130.13 | 2.903E-7 | 0 | -5287 | gtex_brain_putamen_basal |
| rs3735332 | 7 | 149564773 | ATP6V0E2 | ENSG00000171130.13 | 2.903E-7 | 0 | -5284 | gtex_brain_putamen_basal |
| rs3735333 | 7 | 149565163 | ATP6V0E2 | ENSG00000171130.13 | 5.57E-10 | 0 | -4894 | gtex_brain_putamen_basal |
| rs3735334 | 7 | 149565489 | ATP6V0E2 | ENSG00000171130.13 | 2.787E-8 | 0 | -4568 | gtex_brain_putamen_basal |
| rs9640266 | 7 | 149566175 | ATP6V0E2 | ENSG00000171130.13 | 1.168E-8 | 0 | -3882 | gtex_brain_putamen_basal |
| rs17756342 | 7 | 149567098 | ATP6V0E2 | ENSG00000171130.13 | 1.213E-7 | 0 | -2959 | gtex_brain_putamen_basal |
| rs13243007 | 7 | 149567233 | ATP6V0E2 | ENSG00000171130.13 | 2.903E-7 | 0 | -2824 | gtex_brain_putamen_basal |
| rs6980166 | 7 | 149567756 | ATP6V0E2 | ENSG00000171130.13 | 1.213E-7 | 0 | -2301 | gtex_brain_putamen_basal |
| rs4725834 | 7 | 149568262 | ATP6V0E2 | ENSG00000171130.13 | 1.213E-7 | 0 | -1795 | gtex_brain_putamen_basal |
| rs4725835 | 7 | 149568291 | ATP6V0E2 | ENSG00000171130.13 | 5.567E-10 | 0 | -1766 | gtex_brain_putamen_basal |
| rs4725836 | 7 | 149568360 | ATP6V0E2 | ENSG00000171130.13 | 1.168E-8 | 0 | -1697 | gtex_brain_putamen_basal |
| rs10952234 | 7 | 149568903 | ATP6V0E2 | ENSG00000171130.13 | 1.213E-7 | 0 | -1154 | gtex_brain_putamen_basal |
| rs917113 | 7 | 149569205 | ATP6V0E2 | ENSG00000171130.13 | 4.76E-8 | 0 | -852 | gtex_brain_putamen_basal |
| rs4401760 | 7 | 149570693 | ATP6V0E2 | ENSG00000171130.13 | 4.086E-10 | 0 | 636 | gtex_brain_putamen_basal |
| rs10240203 | 7 | 149572842 | ATP6V0E2 | ENSG00000171130.13 | 9.535E-8 | 0 | 2785 | gtex_brain_putamen_basal |
| rs4281039 | 7 | 149573293 | ATP6V0E2 | ENSG00000171130.13 | 1.772E-8 | 0 | 3236 | gtex_brain_putamen_basal |
| rs4469371 | 7 | 149573299 | ATP6V0E2 | ENSG00000171130.13 | 3.438E-7 | 0 | 3242 | gtex_brain_putamen_basal |
| rs4281040 | 7 | 149573340 | ATP6V0E2 | ENSG00000171130.13 | 1.783E-8 | 0 | 3283 | gtex_brain_putamen_basal |
| rs4281041 | 7 | 149573456 | ATP6V0E2 | ENSG00000171130.13 | 1.819E-8 | 0 | 3399 | gtex_brain_putamen_basal |
| rs4419731 | 7 | 149573553 | ATP6V0E2 | ENSG00000171130.13 | 4.348E-8 | 0 | 3496 | gtex_brain_putamen_basal |
| rs7806830 | 7 | 149573977 | ATP6V0E2 | ENSG00000171130.13 | 2.153E-9 | 0 | 3920 | gtex_brain_putamen_basal |
| rs7806974 | 7 | 149574053 | ATP6V0E2 | ENSG00000171130.13 | 2.204E-9 | 0 | 3996 | gtex_brain_putamen_basal |
| rs71531655 | 7 | 149574170 | ATP6V0E2 | ENSG00000171130.13 | 2.313E-9 | 0 | 4113 | gtex_brain_putamen_basal |
| rs10241201 | 7 | 149574268 | ATP6V0E2 | ENSG00000171130.13 | 2.371E-9 | 0 | 4211 | gtex_brain_putamen_basal |
| rs6980260 | 7 | 149575065 | ATP6V0E2 | ENSG00000171130.13 | 2.415E-10 | 0 | 5008 | gtex_brain_putamen_basal |
| rs6980277 | 7 | 149575095 | ATP6V0E2 | ENSG00000171130.13 | 1.024E-8 | 0 | 5038 | gtex_brain_putamen_basal |
| rs6967083 | 7 | 149575638 | ATP6V0E2 | ENSG00000171130.13 | 7.924E-10 | 0 | 5581 | gtex_brain_putamen_basal |
| rs6946997 | 7 | 149575707 | ATP6V0E2 | ENSG00000171130.13 | 1.117E-9 | 0 | 5650 | gtex_brain_putamen_basal |
| rs6947011 | 7 | 149575725 | ATP6V0E2 | ENSG00000171130.13 | 1.028E-8 | 0 | 5668 | gtex_brain_putamen_basal |
| rs5888369 | 7 | 149575747 | ATP6V0E2 | ENSG00000171130.13 | 8.409E-10 | 0 | 5690 | gtex_brain_putamen_basal |
| rs10246226 | 7 | 149575884 | ATP6V0E2 | ENSG00000171130.13 | 7.938E-10 | 0 | 5827 | gtex_brain_putamen_basal |
| rs7785847 | 7 | 149576818 | ATP6V0E2 | ENSG00000171130.13 | 7.938E-10 | 0 | 6761 | gtex_brain_putamen_basal |
| rs7805600 | 7 | 149577161 | ATP6V0E2 | ENSG00000171130.13 | 7.938E-10 | 0 | 7104 | gtex_brain_putamen_basal |
| rs7799585 | 7 | 149577420 | ATP6V0E2 | ENSG00000171130.13 | 7.938E-10 | 0 | 7363 | gtex_brain_putamen_basal |
| rs1133480 | 7 | 149577591 | ATP6V0E2 | ENSG00000171130.13 | 1.387E-7 | 0 | 7534 | gtex_brain_putamen_basal |
| rs67069932 | 7 | 149577936 | ATP6V0E2 | ENSG00000171130.13 | 1.199E-9 | 0 | 7879 | gtex_brain_putamen_basal |
| rs5888370 | 7 | 149578153 | ATP6V0E2 | ENSG00000171130.13 | 3.749E-10 | 0 | 8096 | gtex_brain_putamen_basal |
| rs71194666 | 7 | 149578412 | ATP6V0E2 | ENSG00000171130.13 | 1.263E-9 | 0 | 8355 | gtex_brain_putamen_basal |
| rs4725316 | 7 | 149578566 | ATP6V0E2 | ENSG00000171130.13 | 2.206E-9 | 0 | 8509 | gtex_brain_putamen_basal |
| rs199888029 | 7 | 149578674 | ATP6V0E2 | ENSG00000171130.13 | 8.502E-8 | 0 | 8617 | gtex_brain_putamen_basal |
| rs71194667 | 7 | 149578675 | ATP6V0E2 | ENSG00000171130.13 | 1.033E-10 | 0 | 8618 | gtex_brain_putamen_basal |
| rs4725838 | 7 | 149578949 | ATP6V0E2 | ENSG00000171130.13 | 5.58E-9 | 0 | 8892 | gtex_brain_putamen_basal |
| rs6977798 | 7 | 149579579 | ATP6V0E2 | ENSG00000171130.13 | 2.752E-8 | 0 | 9522 | gtex_brain_putamen_basal |
| rs4348397 | 7 | 149579787 | ATP6V0E2 | ENSG00000171130.13 | 5.28E-8 | 0 | 9730 | gtex_brain_putamen_basal |
| rs10247524 | 7 | 149579948 | ATP6V0E2 | ENSG00000171130.13 | 4.345E-10 | 0 | 9891 | gtex_brain_putamen_basal |
| rs4400299 | 7 | 149580154 | ATP6V0E2 | ENSG00000171130.13 | 1.616E-8 | 0 | 10097 | gtex_brain_putamen_basal |
| rs4394310 | 7 | 149580368 | ATP6V0E2 | ENSG00000171130.13 | 8.392E-8 | 0 | 10311 | gtex_brain_putamen_basal |
| rs6976451 | 7 | 149582747 | ATP6V0E2 | ENSG00000171130.13 | 7.823E-10 | 0 | 12690 | gtex_brain_putamen_basal |
| rs10807975 | 7 | 149583149 | ATP6V0E2 | ENSG00000171130.13 | 1.15E-8 | 0 | 13092 | gtex_brain_putamen_basal |
| rs10807976 | 7 | 149583170 | ATP6V0E2 | ENSG00000171130.13 | 1.15E-8 | 0 | 13113 | gtex_brain_putamen_basal |
| rs12540296 | 7 | 149583591 | ATP6V0E2 | ENSG00000171130.13 | 8.816E-9 | 0 | 13534 | gtex_brain_putamen_basal |
| rs11773140 | 7 | 149583794 | ATP6V0E2 | ENSG00000171130.13 | 1.081E-8 | 0 | 13737 | gtex_brain_putamen_basal |
| rs10245092 | 7 | 149584149 | ATP6V0E2 | ENSG00000171130.13 | 1.521E-8 | 0 | 14092 | gtex_brain_putamen_basal |
| rs6949457 | 7 | 149584953 | ATP6V0E2 | ENSG00000171130.13 | 1.865E-7 | 0 | 14896 | gtex_brain_putamen_basal |
| rs6949468 | 7 | 149584976 | ATP6V0E2 | ENSG00000171130.13 | 2.241E-8 | 0 | 14919 | gtex_brain_putamen_basal |
| rs34103920 | 7 | 149585304 | ATP6V0E2 | ENSG00000171130.13 | 5.025E-9 | 0 | 15247 | gtex_brain_putamen_basal |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KEGG OXIDATIVE PHOSPHORYLATION | 135 | 73 | All SZGR 2.0 genes in this pathway |
| KEGG VIBRIO CHOLERAE INFECTION | 56 | 32 | All SZGR 2.0 genes in this pathway |
| KEGG EPITHELIAL CELL SIGNALING IN HELICOBACTER PYLORI INFECTION | 68 | 44 | All SZGR 2.0 genes in this pathway |
| CHARAFE BREAST CANCER LUMINAL VS BASAL UP | 380 | 215 | All SZGR 2.0 genes in this pathway |
| GRABARCZYK BCL11B TARGETS UP | 81 | 40 | All SZGR 2.0 genes in this pathway |
| RODRIGUES THYROID CARCINOMA ANAPLASTIC DN | 537 | 339 | All SZGR 2.0 genes in this pathway |
| GRAESSMANN APOPTOSIS BY DOXORUBICIN UP | 1142 | 669 | All SZGR 2.0 genes in this pathway |
| GRAESSMANN RESPONSE TO MC AND DOXORUBICIN UP | 612 | 367 | All SZGR 2.0 genes in this pathway |
| PEREZ TP53 TARGETS | 1174 | 695 | All SZGR 2.0 genes in this pathway |
| BUYTAERT PHOTODYNAMIC THERAPY STRESS DN | 637 | 377 | All SZGR 2.0 genes in this pathway |
| RICKMAN TUMOR DIFFERENTIATED WELL VS POORLY UP | 236 | 139 | All SZGR 2.0 genes in this pathway |
| ONDER CDH1 TARGETS 2 UP | 256 | 159 | All SZGR 2.0 genes in this pathway |
| NING CHRONIC OBSTRUCTIVE PULMONARY DISEASE DN | 121 | 79 | All SZGR 2.0 genes in this pathway |
| PENG RAPAMYCIN RESPONSE UP | 203 | 130 | All SZGR 2.0 genes in this pathway |
| SANSOM APC TARGETS DN | 366 | 238 | All SZGR 2.0 genes in this pathway |
| CROMER METASTASIS UP | 79 | 46 | All SZGR 2.0 genes in this pathway |
| AFFAR YY1 TARGETS UP | 214 | 133 | All SZGR 2.0 genes in this pathway |
| THEILGAARD NEUTROPHIL AT SKIN WOUND DN | 225 | 163 | All SZGR 2.0 genes in this pathway |
| STEIN ESRRA TARGETS UP | 388 | 234 | All SZGR 2.0 genes in this pathway |
| COATES MACROPHAGE M1 VS M2 UP | 81 | 52 | All SZGR 2.0 genes in this pathway |
| ACEVEDO NORMAL TISSUE ADJACENT TO LIVER TUMOR DN | 354 | 216 | All SZGR 2.0 genes in this pathway |
| MOOTHA PGC | 420 | 269 | All SZGR 2.0 genes in this pathway |
| JISON SICKLE CELL DISEASE DN | 181 | 97 | All SZGR 2.0 genes in this pathway |
| BOYAULT LIVER CANCER SUBCLASS G6 UP | 65 | 43 | All SZGR 2.0 genes in this pathway |
| CHIANG LIVER CANCER SUBCLASS INTERFERON DN | 52 | 30 | All SZGR 2.0 genes in this pathway |
| YAGI AML WITH INV 16 TRANSLOCATION | 422 | 277 | All SZGR 2.0 genes in this pathway |
| STEIN ESRRA TARGETS | 535 | 325 | All SZGR 2.0 genes in this pathway |
| MARTENS TRETINOIN RESPONSE UP | 857 | 456 | All SZGR 2.0 genes in this pathway |
| KIM ALL DISORDERS OLIGODENDROCYTE NUMBER CORR UP | 756 | 494 | All SZGR 2.0 genes in this pathway |
| KIM BIPOLAR DISORDER OLIGODENDROCYTE DENSITY CORR UP | 682 | 440 | All SZGR 2.0 genes in this pathway |
| KIM ALL DISORDERS DURATION CORR DN | 146 | 90 | All SZGR 2.0 genes in this pathway |
| CHICAS RB1 TARGETS CONFLUENT | 567 | 365 | All SZGR 2.0 genes in this pathway |
| SUMI HNF4A TARGETS | 34 | 14 | All SZGR 2.0 genes in this pathway |
| LIM MAMMARY STEM CELL DN | 428 | 246 | All SZGR 2.0 genes in this pathway |
| LIM MAMMARY LUMINAL MATURE UP | 116 | 65 | All SZGR 2.0 genes in this pathway |
| ZWANG TRANSIENTLY UP BY 2ND EGF PULSE ONLY | 1725 | 838 | All SZGR 2.0 genes in this pathway |