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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets

Gene Ranking Integration

Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets Datasets Gene Ranking

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Gene Page: ADRBK1

Summary

GeneID

156

Symbol

ADRBK1

Synonyms

BARK1|BETA-ARK1|FLJ16718|GRK2

Description

adrenergic, beta, receptor kinase 1

Locus tag

Gene type

protein-coding

Map location

11q13.1

Gene in Data Sources

Gene set name

Method of gene set

Evidence

Info

Network

Shortest path distance of core genes in the Human protein-protein interaction network

Contribution to shortest path in PPI network: 0.0411

General Gene Expression (microarray) ?

Gene Expression in Brain Regions (new)

Top co-expressed genes in Brain Regions (new)

Gene

Pearson's Correlation

Spearman's Correlation

Top 10 positively co-expressed genes

LRPPRC

0.93

CCDC132

0.93

0.91

ARMC8

0.93

0.91

AFTPH

0.93

0.92

CUL2

0.92

PSMD1

0.92

0.89

UBQLN1

0.92

0.90

SHOC2

0.92

MTMR2

0.91

RAD23B

0.91

0.90

Top 10 negatively co-expressed genes

MT-CO2

-0.82

-0.78

FXYD1

-0.80

-0.78

AF347015.8

-0.80

-0.77

AF347015.31

-0.80

-0.77

AF347015.21

-0.79

-0.74

AF347015.33

-0.79

-0.74

MT-CYB

-0.78

-0.75

AF347015.2

-0.77

-0.74

HIGD1B

-0.77

-0.75

AF347015.15

-0.76

-0.75

Gene Ontology

Molecular function

GO term

Evidence

Neuro keywords

PubMed ID

GO:0000166

nucleotide binding

IEA

GO:0004872

receptor activity

IEA

GO:0004871

signal transducer activity

IEA

GO:0004703

G-protein coupled receptor kinase activity

IEA

GO:0005515

protein binding

IEA

GO:0005524

ATP binding

IEA

GO:0016740

transferase activity

IEA

GO:0047696

beta-adrenergic receptor kinase activity

IEA

Biological process

GO term

Evidence

Neuro keywords

PubMed ID

GO:0002026

regulation of the force of heart contraction

IEA

GO:0002029

desensitization of G-protein coupled receptor protein signaling pathway

IEA

GO:0003108

negative regulation of the force of heart contraction by chemical signal

IMP

15051637

GO:0007186

G-protein coupled receptor protein signaling pathway

IEA

GO:0006468

protein amino acid phosphorylation

IEA

GO:0007217

tachykinin signaling pathway

IDA

17986524

GO:0007213

acetylcholine receptor signaling, muscarinic pathway

ISS

GO:0007165

signal transduction

IEA

GO:0007507

heart development

IEA

GO:0018105

peptidyl-serine phosphorylation

ISS

GO:0033605

positive regulation of catecholamine secretion

ISS

GO:0045988

negative regulation of striated muscle contraction

IMP

15051637

GO:0060048

cardiac muscle contraction

IMP

15051637

Cellular component

GO term

Evidence

Neuro keywords

PubMed ID

GO:0005625

soluble fraction

TAS

1339451

GO:0005737

cytoplasm

IDA

17986524

GO:0016020

membrane

IEA

Protein-protein Interactions

Shown by network

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
ADRB2	ADRB2R \| ADRBR \| B2AR \| BAR \| BETA2AR	adrenergic, beta-2-, receptor, surface	Affinity Capture-Western	BioGRID	11309381
AGTR1	AG2S \| AGTR1A \| AGTR1B \| AT1 \| AT1B \| AT1R \| AT2R1 \| AT2R1A \| AT2R1B \| HAT1R	angiotensin II receptor, type 1	Affinity Capture-Western	BioGRID	9211925
AKAP12	AKAP250 \| DKFZp686M0430 \| DKFZp686O0331 \| FLJ20945 \| FLJ97621	A kinase (PRKA) anchor protein 12	-	HPRD	11309381
ARRB1	ARB1 \| ARR1	arrestin, beta 1	-	HPRD	8885248
CAV1	CAV \| MSTP085 \| VIP21	caveolin 1, caveolae protein, 22kDa	Reconstituted Complex	BioGRID	10085129
CCR4	CC-CKR-4 \| CD194 \| CKR4 \| CMKBR4 \| ChemR13 \| HGCN:14099 \| K5-5 \| MGC88293	chemokine (C-C motif) receptor 4	-	HPRD,BioGRID	10754297
EDNRB	ABCDS \| ETB \| ETBR \| ETRB \| HSCR \| HSCR2	endothelin receptor type B	Affinity Capture-Western	BioGRID	9211925
FREQ	DKFZp761L1223 \| FLUP \| NCS-1 \| NCS1	frequenin homolog (Drosophila)	-	HPRD	12351722
FSHR	FSHRO \| LGR1 \| MGC141667 \| MGC141668 \| ODG1	follicle stimulating hormone receptor	-	HPRD,BioGRID	10379886
GIT1	-	G protein-coupled receptor kinase interacting ArfGAP 1	-	HPRD,BioGRID	9826657
GIT2	CAT-2 \| DKFZp686G01261 \| KIAA0148 \| MGC760	G protein-coupled receptor kinase interacting ArfGAP 2	-	HPRD,BioGRID	10896954
GNA15	GNA16	guanine nucleotide binding protein (G protein), alpha 15 (Gq class)	Affinity Capture-Western Reconstituted Complex	BioGRID	12885252
GNAQ	G-ALPHA-q \| GAQ	guanine nucleotide binding protein (G protein), q polypeptide	-	HPRD,BioGRID	12885252
PDC	MEKA \| PHD \| PhLOP \| PhLP	phosducin	-	HPRD,BioGRID	10884381
PDCL	DKFZp564M1863 \| PhLP	phosducin-like	-	HPRD,BioGRID	10884381
PDE6G	DKFZp686C0587 \| MGC125749 \| PDEG	phosphodiesterase 6G, cGMP-specific, rod, gamma	Affinity Capture-Western Reconstituted Complex	BioGRID	12624098
PEBP1	HCNP \| PBP \| PEBP \| RKIP	phosphatidylethanolamine binding protein 1	RKIP interacts with GRK-2. This interaction was modelled on a demonstrated interaction between RKIP from an unspecified species and human GRK-2.	BIND	14654844
PRKCB	MGC41878 \| PKC-beta \| PKCB \| PRKCB1 \| PRKCB2	protein kinase C, beta	-	HPRD	12456365
PRKCB	MGC41878 \| PKC-beta \| PKCB \| PRKCB1 \| PRKCB2	protein kinase C, beta	Affinity Capture-Western Reconstituted Complex	BioGRID	12679936
RCVRN	RCV1	recoverin	-	HPRD	12507501
RHO	CSNBAD1 \| MGC138309 \| MGC138311 \| OPN2 \| RP4	rhodopsin	-	HPRD,BioGRID	10722682
SRC	ASV \| SRC1 \| c-SRC \| p60-Src	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	-	HPRD,BioGRID	12624098

miRNA Targets ?

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-181	1046	1052	m8	hsa-miR-181a^brain	AACAUUCAACGCUGUCGGUGAGU
				hsa-miR-181b^SZ	AACAUUCAUUGCUGUCGGUGGG
				hsa-miR-181c^brain	AACAUUCAACCUGUCGGUGAGU
				hsa-miR-181d^brain	AACAUUCAUUGUUGUCGGUGGGUU
miR-23	1048	1054	m8	hsa-miR-23a^brain	AUCACAUUGCCAGGGAUUUCC
miR-23	1048	1054	m8	hsa-miR-23b^brain	AUCACAUUGCCAGGGAUUACC
miR-26	390	396	1A	hsa-miR-26a^brain	UUCAAGUAAUCCAGGAUAGGC
miR-26	390	396	1A	hsa-miR-26b^SZ	UUCAAGUAAUUCAGGAUAGGUU
miR-323	1048	1054	1A	hsa-miR-323^brain	GCACAUUACACGGUCGACCUCU

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.