Gene Page: DBH

Summary ?
GeneID1621
SymbolDBH
SynonymsDBM
Descriptiondopamine beta-hydroxylase (dopamine beta-monooxygenase)
ReferenceMIM:609312|HGNC:HGNC:2689|Ensembl:ENSG00000123454|HPRD:01963|Vega:OTTHUMG00000020878
Gene typeprotein-coding
Map location9q34
Pascal p-value0.089
Fetal beta0.137
eGeneCortex
Frontal Cortex BA9
Meta
SupportNEUROTRANSMITTER METABOLISM

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenics,schizophrenias,schizotypalClick to show details
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 2 

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
PPP1CB0.920.91
FAM49B0.910.90
STX120.900.91
RAB2A0.900.91
CNOT70.900.89
UBE2N0.900.88
AZIN10.900.88
TMEM680.900.89
RAB180.900.90
TTC330.890.91
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
MT-CO2-0.65-0.64
AF347015.8-0.65-0.66
AF347015.26-0.65-0.65
AF347015.2-0.65-0.64
MT-CYB-0.64-0.64
AF347015.33-0.64-0.63
AF347015.15-0.63-0.64
AF347015.31-0.61-0.61
GPT-0.60-0.63
AF347015.27-0.60-0.61

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004500dopamine beta-monooxygenase activityIEAdopamine (GO term level: 6)-
GO:0005507copper ion bindingIEA-
GO:0004497monooxygenase activityIEA-
GO:0031418L-ascorbic acid bindingIEA-
GO:0046872metal ion bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007268synaptic transmissionTASneuron, Synap, Neurotransmitter (GO term level: 6)2880016 
GO:0009987cellular processIEA-
GO:0006548histidine catabolic processIEA-
GO:0042423catecholamine biosynthetic processIEA-
GO:0055114oxidation reductionIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005576extracellular regionNAS14718574 
GO:0005624membrane fractionTAS3443096 
GO:0005625soluble fractionTAS3443096 
GO:0005737cytoplasmTAS3443096 
GO:0016020membraneIEA-
GO:0016021integral to membraneIEA-
GO:0042583chromaffin granuleNAS-
GO:0031410cytoplasmic vesicleIEA-

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG TYROSINE METABOLISM 4230All SZGR 2.0 genes in this pathway
BIOCARTA NEUROTRANSMITTERS PATHWAY 65All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES 200136All SZGR 2.0 genes in this pathway
REACTOME AMINE DERIVED HORMONES 1512All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY SERUM DEPRIVATION UP 552347All SZGR 2.0 genes in this pathway
RORIE TARGETS OF EWSR1 FLI1 FUSION DN 3023All SZGR 2.0 genes in this pathway
ACEVEDO NORMAL TISSUE ADJACENT TO LIVER TUMOR DN 354216All SZGR 2.0 genes in this pathway
CADWELL ATG16L1 TARGETS UP 9356All SZGR 2.0 genes in this pathway
CHEN METABOLIC SYNDROM NETWORK 1210725All SZGR 2.0 genes in this pathway
MARTENS TRETINOIN RESPONSE UP 857456All SZGR 2.0 genes in this pathway
KIM BIPOLAR DISORDER OLIGODENDROCYTE DENSITY CORR DN 8859All SZGR 2.0 genes in this pathway