Gene Page: DDB1

Summary
GeneID  1642
Symbol  DDB1
Synonyms  DDBA|UV-DDB1|XAP1|XPCE|XPE|XPE-BF
Description  damage-specific DNA binding protein 1, 127kDa
See related  HGNC:2717|MIM:600045|Ensembl:ENSG00000167986|HPRD:10952|
Locus tag  -
Gene type  protein-coding
Map location  11q12-q13
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0156 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
ZFX0.930.94
SAPS30.930.93
AP1G10.930.94
NPAT0.930.95
THUMPD10.930.95
FAF20.920.93
DYRK1A0.920.94
ZRANB10.920.94
USP9X0.920.95
HECTD10.920.94
Top 10 negatively co-expressed genes
AF347015.31-0.76-0.82
FXYD1-0.76-0.81
MT-CO2-0.75-0.81
AF347015.21-0.75-0.85
HIGD1B-0.73-0.81
IFI27-0.72-0.79
AF347015.27-0.72-0.77
AF347015.33-0.72-0.76
AF347015.8-0.71-0.78
AC021016.1-0.70-0.75
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003684damaged DNA bindingTAS8407967 
GO:0005515protein bindingIPI12732143 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0000075cell cycle checkpointIMP17088560 
GO:0000718nucleotide-excision repair, DNA damage removalEXP10583946 
GO:0006511ubiquitin-dependent protein catabolic processIEA-
GO:0044419interspecies interaction between organismsIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusIEA-
GO:0005654nucleoplasmEXP10214908 
GO:0005737cytoplasmIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CDT1DUP | RIS2chromatin licensing and DNA replication factor 1DDB1 interacts with CDT1.BIND15448697 
CUL4A-cullin 4ADDB1 interacts with CUL4A.BIND15448697 
DDB1 Interacts with CUL4A.BIND14739464 
DDB2DDBB | FLJ34321 | UV-DDB2damage-specific DNA binding protein 2, 48kDaDDB1 interacts with DDB2. This interaction was modeled on a demonstrated interaction between hamster DDB1 and human DDB2.BIND15882621 
-HPRD,BioGRID12050362 
DET1FLJ10103 | MGC126156 | MGC126157de-etiolated homolog 1 (Arabidopsis)-HPRD,BioGRID14739464 
hDET1 interacts with DDB1.BIND14739464 
IKBKGAMCBX1 | FIP-3 | FIP3 | Fip3p | IKK-gamma | IP | IP1 | IP2 | IPD2 | NEMOinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma-HPRD14743216 
MAP3K3MAPKKK3 | MEKK3mitogen-activated protein kinase kinase kinase 3-HPRD14743216 
RFWD2COP1 | FLJ10416 | RNF200ring finger and WD repeat domain 2Affinity Capture-WesternBioGRID14739464 
TNFRSF1BCD120b | TBPII | TNF-R-II | TNF-R75 | TNFBR | TNFR1B | TNFR2 | TNFR80 | p75 | p75TNFRtumor necrosis factor receptor superfamily, member 1B-HPRD14743216 
 


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