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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets

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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets Datasets Gene Ranking

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Gene Page: DIAPH1

Summary

GeneID

1729

Symbol

DIAPH1

Synonyms

DFNA1|DIA1|DRF1|FLJ25265|LFHL1|hDIA1

Description

diaphanous homolog 1 (Drosophila)

Locus tag

Gene type

protein-coding

Map location

5q31

Gene in Data Sources

Gene set name

Method of gene set

Evidence

Info

GSMA_I

genome scan meta-analysis

Psr: 0.0032

GO_Annotation

Mapping neuro-related keywords to Gene Ontology annotations

Hits with neuro-related keywords: 2

General Gene Expression (microarray) ?

Gene Expression in Brain Regions (new)

Top co-expressed genes in Brain Regions (new)

Gene

Pearson's Correlation

Spearman's Correlation

Top 10 positively co-expressed genes

INPP4A

0.94

MAPRE2

0.92

DCLK1

0.90

0.91

YWHAG

0.90

0.91

MADD

0.89

0.88

NUDCD3

0.89

0.90

PRKCE

0.89

0.91

HIVEP2

0.89

0.92

AC020663.1

0.89

0.87

PPFIA2

0.88

0.89

Top 10 negatively co-expressed genes

FXYD1

-0.70

-0.67

HIGD1B

-0.68

-0.70

AC021016.1

-0.68

TLCD1

-0.68

-0.67

AP002478.3

-0.67

-0.71

ACSF2

-0.67

-0.69

AF347015.31

-0.65

-0.66

MT-CO2

-0.65

CLDN10

-0.65

-0.63

AF347015.21

-0.65

-0.66

Gene Ontology

Molecular function

GO term

Evidence

Neuro keywords

PubMed ID

GO:0005102

receptor binding

NAS

Neurotransmitter (GO term level: 4)

9360932

GO:0003779

actin binding

IEA

GO:0017048

Rho GTPase binding

IEA

Biological process

GO term

Evidence

Neuro keywords

PubMed ID

GO:0016043

cellular component organization

IEA

GO:0007605

sensory perception of sound

TAS

9360932

GO:0030036

actin cytoskeleton organization

IEA

Cellular component

GO term

Evidence

Neuro keywords

PubMed ID

GO:0042995

cell projection

IEA

axon (GO term level: 4)

GO:0005856

cytoskeleton

IEA

GO:0005737

cytoplasm

IEA

GO:0005886

plasma membrane

IEA

Protein-protein Interactions

Shown by network

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
BAIAP2	BAP2 \| IRSP53	BAI1-associated protein 2	-	HPRD	10814512
CDC7	CDC7L1 \| HsCDC7 \| Hsk1 \| MGC117361 \| MGC126237 \| MGC126238 \| huCDC7	cell division cycle 7 homolog (S. cerevisiae)	-	HPRD	12065429
CENPA	CENP-A	centromere protein A	mDia1 interacts with CENP-A. This interaction was modelled on a demonstrated interaction between mDia1 from mouse and CENP-A from human.	BIND	15085137
PKD2	APKD2 \| MGC138466 \| MGC138468 \| PC2 \| PKD4	polycystic kidney disease 2 (autosomal dominant)	PKD2 interacts with DRF1. This interaction was modeled on a demonstrated interaction between human PKD2 and mouse DRF1.	BIND	15123714
RAC1	MGC111543 \| MIG5 \| TC-25 \| p21-Rac1	ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)	-	HPRD	11590143
RHOA	ARH12 \| ARHA \| RHO12 \| RHOH12	ras homolog gene family, member A	Reconstituted Complex Two-hybrid	BioGRID	12773565
XPO6	EXP6 \| FLJ22519 \| KIAA0370 \| RANBP20	exportin 6	-	HPRD,BioGRID	14592989

miRNA Targets ?

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-124.1	268	275	1A,m8	hsa-miR-124a	UUAAGGCACGCGGUGAAUGCCA
miR-124/506	268	274	1A	hsa-miR-506	UAAGGCACCCUUCUGAGUAGA
miR-124/506	268	274	1A	hsa-miR-124^brain	UAAGGCACGCGGUGAAUGCC
miR-33	1732	1738	1A	hsa-miR-33	GUGCAUUGUAGUUGCAUUG
miR-33	1732	1738	1A	hsa-miR-33b	GUGCAUUGCUGUUGCAUUGCA
miR-330	1647	1653	1A	hsa-miR-330^brain	GCAAAGCACACGGCCUGCAGAGA
miR-452	1734	1740	m8	hsa-miR-452	UGUUUGCAGAGGAAACUGAGAC
miR-9	245	251	m8	hsa-miR-9^SZ	UCUUUGGUUAUCUAGCUGUAUGA

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.