Gene Page: DOCK1

Summary
GeneID  1793
Symbol  DOCK1
Synonyms  DOCK180|ced5
Description  dedicator of cytokinesis 1
See related  HGNC:2987|MIM:601403|HPRD:03240|
Locus tag  RP11-82L9.1
Gene type  protein-coding
Map location  10q26.13-q26.3
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_IIAgenome scan meta-analysis (All samples)Psr: 0.03487 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
SCN1B0.570.46
ESRRG0.530.22
HTR1B0.530.19
LRRC380.510.41
ANKRD290.510.43
STAC20.480.40
FBLN70.480.47
PVALB0.480.48
VAMP10.470.43
NRG40.460.40
Top 10 negatively co-expressed genes
FADS2-0.21-0.32
WDR86-0.20-0.31
AC092111.1-0.19-0.19
FAM59B-0.19-0.30
OLFM2-0.19-0.22
PKN1-0.18-0.33
SH2B2-0.18-0.39
SH3BP2-0.18-0.39
SLC19A1-0.18-0.29
CDC42EP4-0.18-0.31
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005085guanyl-nucleotide exchange factor activityIEA-
GO:0005096GTPase activator activityTAS9808620 
GO:0005515protein bindingIPI12134158 |15247908 
GO:0017124SH3 domain bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007229integrin-mediated signaling pathwayTAS9808620 
GO:0007165signal transductionTAS8661160 
GO:0007264small GTPase mediated signal transductionTAS9808620 
GO:0006915apoptosisTAS9548255 
GO:0006911phagocytosis, engulfmentTAS9548255 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005737cytoplasmTAS8661160 
GO:0016020membraneIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
BCAR1CAS | CAS1 | CASS1 | CRKAS | P130Casbreast cancer anti-estrogen resistance 1-HPRD,BioGRID12615911 
CRKCRKIIv-crk sarcoma virus CT10 oncogene homolog (avian)Affinity Capture-Western
Co-fractionation
Reconstituted Complex		BioGRID8657152 |8662907 
|10559471 |11369773 
|12615911 
-HPRD8657152|11369773 
ELMO1CED-12 | CED12 | ELMO-1 | KIAA0281 | MGC126406engulfment and cell motility 1-HPRD,BioGRID11595183 
Dock180 interacts with ELMO, resulting in unfolding of Dock180.BIND15723800 
-HPRD12134158 
ELMO1 interacts with Dock180.BIND12134158 
ELMO2CED-12 | CED12 | ELMO-2 | FLJ11656 | KIAA1834engulfment and cell motility 2-HPRD11703939 
GRB2ASH | EGFRBP-GRB2 | Grb3-3 | MST084 | MSTP084growth factor receptor-bound protein 2Co-fractionation
Reconstituted Complex		BioGRID8657152 |12615911 
JMJD6KIAA0585 | PSR | PTDSR | PTDSR1jumonji domain containing 6PSR interacts with DOCK180. This interaction was modelled on a demonstrated interaction between PSR from human and CED-5 from Caenorhabditis elegans.BIND14645848 
NCK2GRB4 | NCKbetaNCK adaptor protein 2-HPRD,BioGRID11240126 
PTK2FADK | FAK | FAK1 | pp125FAKPTK2 protein tyrosine kinase 2Affinity Capture-WesternBioGRID12615911 
RAC1MGC111543 | MIG5 | TC-25 | p21-Rac1ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)Rac interacts with Dock180.BIND12134158 
-HPRD,BioGRID9808620 
RHOGARHG | MGC125835 | MGC125836ras homolog gene family, member G (rho G)-HPRD,BioGRID12879077 
SRCASV | SRC1 | c-SRC | p60-Srcv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)Affinity Capture-WesternBioGRID12615911 
WASF2SCAR2 | WAVE2 | dJ393P12.2WAS protein family, member 2-HPRD11773052 
 
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-1823073131Ahsa-miR-182UUUGGCAAUGGUAGAACUCACA
miR-31281287m8hsa-miR-31AGGCAAGAUGCUGGCAUAGCUG
miR-3817577631Ahsa-miR-381UAUACAAGGGCAAGCUCUCUGU
hsa-miR-381UAUACAAGGGCAAGCUCUCUGU
miR-963063131A,m8hsa-miR-96brainUUUGGCACUAGCACAUUUUUGC
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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