Gene Page: AGTR2

Summary
GeneID  186
Symbol  AGTR2
Synonyms  AT2|ATGR2|MRX88
Description  angiotensin II receptor, type 2
See related  HGNC:338|MIM:300034|Ensembl:ENSG00000180772|HPRD:02071|
Locus tag  -
Gene type  protein-coding
Map location  Xq22-q23
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 2 
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0576 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004872receptor activityIEA-
GO:0004947bradykinin receptor activityIEA-
GO:0005515protein bindingIPI18344519 
GO:0004945angiotensin type II receptor activityTAS8502225 
GO:0048019receptor antagonist activityTAS17159079 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007420brain developmentNASBrain (GO term level: 7)12089445 
GO:0002035brain renin-angiotensin systemIEABrain (GO term level: 12)-
GO:0001991regulation of systemic arterial blood pressure by circulatory renin-angiotensinISS-
GO:0002033vasodilation by angiotensin involved in regulation of systemic arterial blood pressureIEA-
GO:0001974blood vessel remodelingTAS17159080 
GO:0007186G-protein coupled receptor protein signaling pathwayIEA-
GO:0007199G-protein signaling, coupled to cGMP nucleotide second messengerISS17000928 
GO:0008217regulation of blood pressureTAS7477266 
GO:0007263nitric oxide mediated signal transductionIC17000928 
GO:0007263nitric oxide mediated signal transductionTAS17159080 
GO:0007243protein kinase cascadeISS17000928 
GO:0010459negative regulation of heart rateISS-
GO:0007610behaviorIMP12089445 
GO:0007610behaviorISS-
GO:0043065positive regulation of apoptosisIMP10406457 
GO:0051000positive regulation of nitric-oxide synthase activityISS17000928 
GO:0030308negative regulation of cell growthTAS17159080 
GO:0032516positive regulation of phosphoprotein phosphatase activityIDA10406457 
GO:0045909positive regulation of vasodilationIDA15117835 |17159079 
GO:0043537negative regulation of blood vessel endothelial cell migrationNAS15710780 
GO:0045429positive regulation of nitric oxide biosynthetic processIC17000928 
GO:0051387negative regulation of nerve growth factor receptor signaling pathwayIMP10406457 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005886plasma membraneIEA-
GO:0005887integral to plasma membraneTAS7945336 
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
AGTANHU | FLJ92595 | FLJ97926 | SERPINA8angiotensinogen (serpin peptidase inhibitor, clade A, member 8)-HPRD11709400 
AGTRAPATRAP | MGC29646angiotensin II receptor-associated proteinReconstituted ComplexBioGRID11733189 
ERBB2CD340 | HER-2 | HER-2/neu | HER2 | NEU | NGL | TKR1v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)-HPRD10710290 
ERBB3ErbB-3 | HER3 | LCCS2 | MDA-BF-1 | MGC88033 | c-erbB-3 | c-erbB3 | erbB3-S | p180-ErbB3 | p45-sErbB3 | p85-sErbB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)-HPRD10710290 
MTUS1ATIP | DKFZp586D1519 | DKFZp686F20243 | FLJ14295 | KIAA1288 | MP44 | MTSG1mitochondrial tumor suppressor 1-HPRD,BioGRID15123706 
ZBTB16PLZF | ZNF145zinc finger and BTB domain containing 16-HPRD14657020 
 
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-3308468531A,m8hsa-miR-330brainGCAAAGCACACGGCCUGCAGAGA
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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