Gene Page: EDA

Summary ?
GeneID1896
SymbolEDA
SynonymsECTD1|ED1|ED1-A1|ED1-A2|EDA-A1|EDA-A2|EDA1|EDA2|HED|HED1|ODT1|STHAGX1|TNLG7C|XHED|XLHED
Descriptionectodysplasin A
ReferenceMIM:300451|HGNC:HGNC:3157|Ensembl:ENSG00000158813|HPRD:02347|Vega:OTTHUMG00000021764
Gene typeprotein-coding
Map locationXq12-q13.1
Fetal beta1.25

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenics,schizotypy,schizophrenias,schizotypalClick to show details
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
LAMA40.760.73
ETS10.730.78
LAMC10.710.70
FN10.710.71
VCL0.690.70
PCDH180.690.70
FLVCR20.690.59
NID10.690.64
ELK30.680.72
OLFML30.680.63
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
FXYD1-0.39-0.36
AF347015.21-0.39-0.38
MT-CO2-0.37-0.40
S100A13-0.36-0.34
MT1G-0.36-0.34
AC098691.2-0.35-0.36
APOC1-0.34-0.30
AF347015.31-0.34-0.37
CA5A-0.34-0.32
AF347015.8-0.34-0.37

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005102receptor bindingIDANeurotransmitter (GO term level: 4)11039935 
GO:0005164tumor necrosis factor receptor bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0001942hair follicle developmentIEA-
GO:0007160cell-matrix adhesionIEA-
GO:0007398ectoderm developmentTAS8696334 
GO:0007165signal transductionTAS8696334 
GO:0007431salivary gland developmentIEA-
GO:0006955immune responseIEA-
GO:0007275multicellular organismal developmentIEA-
GO:0042346positive regulation of NF-kappaB import into nucleusIEA-
GO:0030154cell differentiationIEA-
GO:0051092positive regulation of NF-kappaB transcription factor activityIDA11039935 
GO:0042475odontogenesis of dentine-containing toothIEA-
GO:0043473pigmentationIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005856cytoskeletonTAS10484778 
GO:0005789endoplasmic reticulum membraneIEA-
GO:0005576extracellular regionIEA-
GO:0005624membrane fractionTAS8696334 
GO:0005886plasma membraneTAS9736768 |10484778 
GO:0005887integral to plasma membraneIEA-
GO:0045177apical part of cellIEA-

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG CYTOKINE CYTOKINE RECEPTOR INTERACTION 267161All SZGR 2.0 genes in this pathway
PARENT MTOR SIGNALING UP 567375All SZGR 2.0 genes in this pathway
ODONNELL METASTASIS UP 8258All SZGR 2.0 genes in this pathway
WANG PROSTATE CANCER ANDROGEN INDEPENDENT 6637All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 20HR UP 240152All SZGR 2.0 genes in this pathway
MITSIADES RESPONSE TO APLIDIN DN 249165All SZGR 2.0 genes in this pathway
WANG MLL TARGETS 289188All SZGR 2.0 genes in this pathway
DURAND STROMA S UP 297194All SZGR 2.0 genes in this pathway
NABA SECRETED FACTORS 344197All SZGR 2.0 genes in this pathway
NABA MATRISOME ASSOCIATED 753411All SZGR 2.0 genes in this pathway
NABA MATRISOME 1028559All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
let-7/98845851m8hsa-let-7abrainUGAGGUAGUAGGUUGUAUAGUU
hsa-let-7bbrainUGAGGUAGUAGGUUGUGUGGUU
hsa-let-7cbrainUGAGGUAGUAGGUUGUAUGGUU
hsa-let-7dbrainAGAGGUAGUAGGUUGCAUAGU
hsa-let-7ebrainUGAGGUAGGAGGUUGUAUAGU
hsa-let-7fbrainUGAGGUAGUAGAUUGUAUAGUU
hsa-miR-98brainUGAGGUAGUAAGUUGUAUUGUU
hsa-let-7gSZUGAGGUAGUAGUUUGUACAGU
hsa-let-7ibrainUGAGGUAGUAGUUUGUGCUGU
miR-130/3013133201A,m8hsa-miR-130abrainCAGUGCAAUGUUAAAAGGGCAU
hsa-miR-301CAGUGCAAUAGUAUUGUCAAAGC
hsa-miR-130bbrainCAGUGCAAUGAUGAAAGGGCAU
hsa-miR-454-3pUAGUGCAAUAUUGCUUAUAGGGUUU
miR-1494652m8hsa-miR-149brainUCUGGCUCCGUGUCUUCACUCC
miR-15/16/195/424/4977278m8hsa-miR-15abrainUAGCAGCACAUAAUGGUUUGUG
hsa-miR-16brainUAGCAGCACGUAAAUAUUGGCG
hsa-miR-15bbrainUAGCAGCACAUCAUGGUUUACA
hsa-miR-195SZUAGCAGCACAGAAAUAUUGGC
hsa-miR-424CAGCAGCAAUUCAUGUUUUGAA
hsa-miR-497CAGCAGCACACUGUGGUUUGU
hsa-miR-15abrainUAGCAGCACAUAAUGGUUUGUG
hsa-miR-16brainUAGCAGCACGUAAAUAUUGGCG
hsa-miR-15bbrainUAGCAGCACAUCAUGGUUUACA
hsa-miR-195SZUAGCAGCACAGAAAUAUUGGC
hsa-miR-424CAGCAGCAAUUCAUGUUUUGAA
hsa-miR-497CAGCAGCACACUGUGGUUUGU
miR-1504248m8hsa-miR-150UCUCCCAACCCUUGUACCAGUG
miR-22627633m8hsa-miR-22brainAAGCUGCCAGUUGAAGAACUGU
miR-24303930461A,m8hsa-miR-24SZUGGCUCAGUUCAGCAGGAACAG
miR-324-5p314231481Ahsa-miR-324-5pCGCAUCCCCUAGGGCAUUGGUGU
miR-342374837551A,m8hsa-miR-342brainUCUCACACAGAAAUCGCACCCGUC