Gene Page

Gene Page: EFNA3

Summary

GeneID

1944

Symbol

EFNA3

Synonyms

EFL2|EPLG3|Ehk1-L|LERK3

Description

ephrin-A3

Locus tag

Gene type

protein-coding

Map location

1q21-q22

Gene in Data Sources

Gene set name

Method of gene set

Evidence

Info

GSMA_I

genome scan meta-analysis

Psr: 0.0235

GSMA_IIA

genome scan meta-analysis (All samples)

Psr: 0.00814

General Gene Expression (microarray) ?

Gene Expression in Brain Regions (new)

Top co-expressed genes in Brain Regions (new)

Gene

Pearson's Correlation

Spearman's Correlation

Top 10 positively co-expressed genes

Top 10 negatively co-expressed genes

Gene Ontology

Molecular function

GO term

Evidence

Neuro keywords

PubMed ID

GO:0005005

transmembrane-ephrin receptor activity

TAS

8660976

Biological process

GO term

Evidence

Neuro keywords

PubMed ID

GO:0007267

cell-cell signaling

TAS

8660976

Cellular component

GO term

Evidence

Neuro keywords

PubMed ID

GO:0005886

plasma membrane

IEA

GO:0005887

integral to plasma membrane

TAS

8660976

GO:0031225

anchored to membrane

IEA

Interactions

Shown by Network

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
EPHA2	ECK	EPH receptor A2	The membrane bound ligand EHK1-L interacts with the receptor ECK. This interaction was modeled on a demonstrated interaction between EHK1-L from human and ECK from mouse.	BIND	7973638 \|8755474
EPHA2	ECK	EPH receptor A2	-	HPRD	12907451
EPHA3	ETK \| ETK1 \| HEK \| HEK4 \| TYRO4	EPH receptor A3	Reconstituted Complex	BioGRID	9195962
EPHA4	HEK8 \| SEK \| TYRO1	EPH receptor A4	-	HPRD	12496762
EPHA5	CEK7 \| EHK1 \| HEK7 \| TYRO4	EPH receptor A5	The membrane bound ligand EHK1-L interacts with the receptor EHK1. This interaction was modeled on a demonstrated interaction between EHK1-L from human and EHK1 from rat.	BIND	7973638 \|8755474
EPHA5	CEK7 \| EHK1 \| HEK7 \| TYRO4	EPH receptor A5	-	HPRD	10516308
EPHA7	EHK3 \| HEK11	EPH receptor A7	Affinity Capture-Western	BioGRID	10366629
PRSS23	MGC5107 \| SIG13 \| SPUVE \| ZSIG13	protease, serine, 23	Two-hybrid	BioGRID	16169070

miRNA Targets ?

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-137	474	480	1A	hsa-miR-137	UAUUGCUUAAGAAUACGCGUAG
miR-145	978	984	m8	hsa-miR-145	GUCCAGUUUUCCCAGGAAUCCCUU
miR-153	791	798	1A,m8	hsa-miR-153	UUGCAUAGUCACAAAAGUGA
miR-210	798	804	m8	hsa-miR-210	CUGUGCGUGUGACAGCGGCUGA
miR-224	941	947	m8	hsa-miR-224	CAAGUCACUAGUGGUUCCGUUUA
miR-27	776	782	1A	hsa-miR-27a^brain	UUCACAGUGGCUAAGUUCCGC
miR-27	776	782	1A	hsa-miR-27b^brain	UUCACAGUGGCUAAGUUCUGC
miR-30-5p	467	474	1A,m8	hsa-miR-30a-5p	UGUAAACAUCCUCGACUGGAAG
				hsa-miR-30c^brain	UGUAAACAUCCUACACUCUCAGC
				hsa-miR-30d^SZ	UGUAAACAUCCCCGACUGGAAG
				hsa-miR-30b^SZ	UGUAAACAUCCUACACUCAGCU
				hsa-miR-30e-5p	UGUAAACAUCCUUGACUGGA
				hsa-miR-30a-5p	UGUAAACAUCCUCGACUGGAAG
				hsa-miR-30c^brain	UGUAAACAUCCUACACUCUCAGC
				hsa-miR-30d^SZ	UGUAAACAUCCCCGACUGGAAG
				hsa-miR-30b^SZ	UGUAAACAUCCUACACUCAGCU
				hsa-miR-30e-5p	UGUAAACAUCCUUGACUGGA
miR-330	931	937	m8	hsa-miR-330^brain	GCAAAGCACACGGCCUGCAGAGA
miR-448	792	798	1A	hsa-miR-448	UUGCAUAUGUAGGAUGUCCCAU
miR-493-5p	615	621	m8	hsa-miR-493-5p	UUGUACAUGGUAGGCUUUCAUU
miR-493-5p	615	621	m8	hsa-miR-493-5p	UUGUACAUGGUAGGCUUUCAUU

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.