Gene Page: EIF2B1

Summary
GeneID  1967
Symbol  EIF2B1
Synonyms  EIF-2B|EIF-2Balpha|EIF2B|EIF2BA|MGC117409|MGC125868|MGC125869
Description  eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa
See related  HGNC:3257|MIM:606686|Ensembl:ENSG00000111361|HPRD:09458|
Locus tag  -
Gene type  protein-coding
Map location  12q24.31
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0132 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
YWHAQ0.950.95
SLC39A60.950.97
GPN10.940.96
WDR40A0.940.95
CRY10.940.95
ZNF5120.940.97
HISPPD10.940.96
PJA10.940.95
HSDL10.940.96
C9orf300.930.95
Top 10 negatively co-expressed genes
AF347015.31-0.78-0.91
AF347015.27-0.78-0.90
MT-CO2-0.78-0.92
HLA-F-0.77-0.81
AF347015.33-0.77-0.90
FXYD1-0.76-0.89
MT-CYB-0.75-0.89
AIFM3-0.75-0.79
AF347015.8-0.75-0.91
C5orf53-0.74-0.75
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005085guanyl-nucleotide exchange factor activityIDA11323413 
GO:0003743translation initiation factor activityIDA16289705 
GO:0005515protein bindingIPI9235896 |17353931 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0014003oligodendrocyte developmentIMPaxon, oligodendrocyte, Glial (GO term level: 10)15217090 
GO:0006413translational initiationIDA16289705 
GO:0009408response to heatISS-
GO:0009408response to heatTAS12499492 
GO:0009749response to glucose stimulusISS-
GO:0043434response to peptide hormone stimulusISS-
GO:0044237cellular metabolic processIEA-
GO:0051716cellular response to stimulusIDA8626696 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005851eukaryotic translation initiation factor 2B complexIDA11323413 |15060152 
GO:0005624membrane fractionIDA9235896 
GO:0005737cytoplasmIDA11323413 
GO:0005886plasma membraneIDA9235896 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ADRA2AADRA2 | ADRA2R | ADRAR | ALPHA2AAR | ZNF32adrenergic, alpha-2A-, receptor-HPRD9235896 
ADRA2BADRA2L1 | ADRA2RL1 | ADRARL1 | ALPHA2BARadrenergic, alpha-2B-, receptor-HPRD,BioGRID9235896 
ADRA2CADRA2L2 | ADRA2RL2 | ADRARL2 | ALPHA2CARadrenergic, alpha-2C-, receptor-HPRD,BioGRID9235896 
ADRB2ADRB2R | ADRBR | B2AR | BAR | BETA2ARadrenergic, beta-2-, receptor, surfaceeIF2B-alpha interacts with the cytoplasmic, carboxy-terminus of the beta-2 adrenergic receptor.BIND9235896 
-HPRD,BioGRID9235896 
ARHGDIAGDIA1 | MGC117248 | RHOGDI | RHOGDI-1Rho GDP dissociation inhibitor (GDI) alphaAffinity Capture-MSBioGRID17353931 
ARL4DARF4L | ARL6ADP-ribosylation factor-like 4DTwo-hybridBioGRID16169070 
DCDAIDD | DCD-1 | DSEP | HCAP | MGC71930 | PIFdermcidinAffinity Capture-MSBioGRID17353931 
EIF2B2EIF-2Bbeta | EIF2Beukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa-HPRD9446619 |10805739 
EIF2B3EIF-2B | EIF2Bgammaeukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDaAffinity Capture-MSBioGRID17353931 
EIF2B5CACH | CLE | EIF-2B | EIF2Bepsilon | LVWMeukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDaAffinity Capture-MS
Reconstituted Complex		BioGRID10858531 |17353931 
EIF2S1EIF-2 | EIF-2A | EIF-2alpha | EIF2 | EIF2Aeukaryotic translation initiation factor 2, subunit 1 alpha, 35kDaReconstituted ComplexBioGRID9446619 
EIF2S2DKFZp686L18198 | EIF2 | EIF2B | EIF2beta | MGC8508eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa-HPRD9446619 
HNRNPLFLJ35509 | HNRPL | P/OKcl.14 | hnRNP-Lheterogeneous nuclear ribonucleoprotein LAffinity Capture-MSBioGRID17353931 
MRPL4CGI-28 | L4mt | MGC16367 | MGC2681mitochondrial ribosomal protein L4Two-hybridBioGRID16169070 
PDIA4ERP70 | ERP72protein disulfide isomerase family A, member 4Affinity Capture-MSBioGRID17353931 
 


Copyright © Bioinformatics and Systems Medicine Laboratory All Rights Reserved since 2009.