Gene Page: EIF4G1

Summary
GeneID  1981
Symbol  EIF4G1
Synonyms  DKFZp686A1451|EIF4F|EIF4G|p220
Description  eukaryotic translation initiation factor 4 gamma, 1
See related  HGNC:3296|MIM:600495|Ensembl:ENSG00000114867|HPRD:06774|
Locus tag  -
Gene type  protein-coding
Map location  3q27-qter
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0113 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
ATF20.920.94
IPO50.920.92
LASS60.910.94
ELAVL20.910.94
NUDT210.900.92
KLHDC100.890.92
FBXO210.890.92
CAPRIN10.890.92
PAFAH1B20.890.91
CUL4B0.890.91
Top 10 negatively co-expressed genes
FXYD1-0.72-0.83
MT-CO2-0.71-0.83
AF347015.31-0.71-0.82
AF347015.33-0.69-0.79
MT-CYB-0.69-0.80
HSD17B14-0.68-0.75
HIGD1B-0.68-0.80
TSC22D4-0.68-0.74
AF347015.8-0.68-0.82
AF347015.27-0.68-0.80
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003723RNA bindingIEA-
GO:0003743translation initiation factor activityIEA-
GO:0003743translation initiation factor activityTAS8961935 |9372926 
GO:0005515protein bindingIPI10970864 |10996799 |12054647 
|14701818 |15713657 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006446regulation of translational initiationNAS8961935 |9372926 
GO:0016070RNA metabolic processIEA-
GO:0044419interspecies interaction between organismsIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005829cytosolEXP8449919 |12588972 |15314020 
GO:0005737cytoplasmNAS-
GO:0016281eukaryotic translation initiation factor 4F complexTAS9857202 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
EIF3AEIF3 | EIF3S10 | KIAA0139 | P167 | TIF32 | eIF3-p170 | eIF3-theta | p180 | p185eukaryotic translation initiation factor 3, subunit AAffinity Capture-WesternBioGRID16541103 
EIF3BEIF3-ETA | EIF3-P110 | EIF3-P116 | EIF3S9 | MGC104664 | MGC131875 | PRT1eukaryotic translation initiation factor 3, subunit BAffinity Capture-WesternBioGRID16541103 
EIF3IEIF3S2 | PRO2242 | TRIP-1 | TRIP1 | eIF3-beta | eIF3-p36eukaryotic translation initiation factor 3, subunit IAffinity Capture-WesternBioGRID16541103 
EIF4A1DDX2A | EIF-4A | EIF4Aeukaryotic translation initiation factor 4A, isoform 1-HPRD9372926 |11408474 
Affinity Capture-MS
Affinity Capture-Western		BioGRID16541103 |16648488 
|17353931 
EIF4A2BM-010 | DDX2B | EIF4A | EIF4Feukaryotic translation initiation factor 4A, isoform 2Affinity Capture-MSBioGRID17353931 
-HPRD11408474 
EIF4ECBP | EIF4E1 | EIF4EL1 | EIF4F | MGC111573eukaryotic translation initiation factor 4E-HPRD,BioGRID10600798 
-HPRD9372926 |10600798|10600798 
EIF4E interacts with eIF4G1. This interaction was modeled on a demonstrated interaction between mouse eIF4E and human eIF4G1.BIND9878069 
eIF4GI interacts with eIF4E. This interaction was modeled on a demonstrated interaction between human eIF4GI and monkey eIF4E.BIND15361857 
eIF-4E interacts with an unspecified isoform of eIF-4G.BIND15897904 
EIF5EIF-5Aeukaryotic translation initiation factor 5-HPRD11331597 
GABARAPL2ATG8 | GATE-16 | GATE16 | GEF-2 | GEF2GABA(A) receptor-associated protein-like 2Affinity Capture-MSBioGRID17353931 
HSPB1CMT2F | DKFZp586P1322 | HMN2B | HS.76067 | HSP27 | HSP28 | Hsp25 | SRP27heat shock 27kDa protein 1-HPRD10859165 
MAGEA6MAGE-3b | MAGE3B | MAGE6 | MGC52297melanoma antigen family A, 6Affinity Capture-MSBioGRID17353931 
MKNK1MNK1MAP kinase interacting serine/threonine kinase 1Mnk1 interacts with eIF4G1.BIND9878069 
-HPRD9878069 |15234964 
-HPRD,BioGRID9878069 
MKNK2GPRK7 | MNK2MAP kinase interacting serine/threonine kinase 2Affinity Capture-Western
Biochemical Activity		BioGRID12897141 
NCBP1CBP80 | MGC2087 | NCBPnuclear cap binding protein subunit 1, 80kDaeIF4GI interacts with CBP80BIND15361857 
-HPRD,BioGRID11340157 
NCBP2CBC2 | CBP20 | NIP1 | PIG55nuclear cap binding protein subunit 2, 20kDaeIF4GI interacts with CBP20BIND15361857 
PABPC1PAB1 | PABP | PABP1 | PABPC2 | PABPL1poly(A) binding protein, cytoplasmic 1-HPRD,BioGRID9857202 
PDCD4H731 | MGC33046 | MGC33047programmed cell death 4 (neoplastic transformation inhibitor)-HPRD,BioGRID12054647 
TH1LHSPC130 | NELF-C | NELF-D | TH1TH1-like (Drosophila)Affinity Capture-MSBioGRID17353931 
ZC3H7BDKFZp434K0920 | FLJ13787 | KIAA1031 | RoXaNzinc finger CCCH-type containing 7B-HPRD15047801 
 
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-214377383m8hsa-miR-214brainACAGCAGGCACAGACAGGCAG
miR-324-3p9298m8hsa-miR-324-3pCCACUGCCCCAGGUGCUGCUGG
miR-329250256m8hsa-miR-329brainAACACACCUGGUUAACCUCUUU
miR-503340346m8hsa-miR-503UAGCAGCGGGAACAGUUCUGCAG
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


Copyright © Bioinformatics and Systems Medicine Laboratory All Rights Reserved since 2009.