Gene Page: ERCC3

Summary
GeneID  2071
Symbol  ERCC3
Synonyms  BTF2|GTF2H|RAD25|TFIIH|XPB
Description  excision repair cross-complementing rodent repair deficiency, complementation group 3 (xeroderma pigmentosum group B complementing)
See related  HGNC:3435|MIM:133510|Ensembl:ENSG00000163161|HPRD:00593|
Locus tag  -
Gene type  protein-coding
Map location  2q21
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_Igenome scan meta-analysisPsr: 0.023 
GSMA_IIAgenome scan meta-analysis (All samples)Psr: 0.00755 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
C2orf160.680.67
ATP6V0A20.650.63
PCGF30.650.69
NR2C20.650.68
XRN10.650.63
FBN10.650.49
LAMB10.650.62
TUG10.650.61
UBN20.650.62
SRRM10.650.65
Top 10 negatively co-expressed genes
HIGD1B-0.55-0.63
MT-CO2-0.53-0.57
AF347015.31-0.52-0.57
AF347015.21-0.51-0.60
AF347015.2-0.51-0.54
MT-CYB-0.51-0.55
AC131097.1-0.51-0.59
IFI27-0.50-0.54
AF347015.8-0.50-0.56
HSD17B14-0.49-0.53
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0003684damaged DNA bindingNAS2167179 
GO:0004003ATP-dependent DNA helicase activityIEA-
GO:0005524ATP bindingIEA-
GO:0004386helicase activityIEA-
GO:0016787hydrolase activityIEA-
GO:0008134transcription factor bindingIDA9173976 
GO:0008022protein C-terminus bindingIPI10801852 |17466626 
GO:0016887ATPase activityIDA17466626 
GO:00431383'-5' DNA helicase activityIDA17466626 
GO:00431383'-5' DNA helicase activityIMP8663148 
GO:0047485protein N-terminus bindingIPI8652557 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0000075cell cycle checkpointIMP17088560 
GO:0000717nucleotide-excision repair, DNA duplex unwindingIMP17466626 
GO:0000718nucleotide-excision repair, DNA damage removalEXP10583946 
GO:0006355regulation of transcription, DNA-dependentIEA-
GO:0006367transcription initiation from RNA polymerase II promoterEXP8946909 
GO:0006368RNA elongation from RNA polymerase II promoterEXP9405375 
GO:0006350transcriptionIEA-
GO:0006283transcription-coupled nucleotide-excision repairIDA8663148 
GO:0006265DNA topological changeIMP8663148 
GO:0006917induction of apoptosisIDA16914395 
GO:0006917induction of apoptosisIMP8675009 
GO:0009650UV protectionIEA-
GO:0008104protein localizationIMP17509950 
GO:0007605sensory perception of soundIEA-
GO:0006979response to oxidative stressIMP17614221 
GO:0035315hair cell differentiationIMP11335038 
GO:0033683nucleotide-excision repair, DNA incisionIMP8692841 |17466626 
GO:0045944positive regulation of transcription from RNA polymerase II promoterIDA8692841 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusTAS8663148 
GO:0005654nucleoplasmEXP1939271 |2449431 |8946909 
|9512541 |9582279 
|9790902 |10214908 
|11313499 |12393749 
|12646563 
GO:0005675holo TFIIH complexIDA8692842 
GO:0005675holo TFIIH complexTAS7663514 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
BCRALL | BCR-ABL1 | BCR1 | CML | D22S11 | D22S662 | FLJ16453 | PHLbreakpoint cluster region-HPRD,BioGRID9874796 
CCND1BCL1 | D11S287E | PRAD1 | U21B31cyclin D1TFIIH interacts with Cyclin D1 promoter.BIND15893730 
CCNHCAK | p34 | p37cyclin HCo-purificationBioGRID15220921 
CDK7CAK1 | CDKN7 | MO15 | STK1 | p39MO15cyclin-dependent kinase 7-HPRD,BioGRID9130708 
ERCC2COFS2 | EM9 | MGC102762 | MGC126218 | MGC126219 | TTD | XPDexcision repair cross-complementing rodent repair deficiency, complementation group 2-HPRD,BioGRID8652557 
GTF2E1FE | TF2E1 | TFIIE-Ageneral transcription factor IIE, polypeptide 1, alpha 56kDa-HPRD,BioGRID7926747 |8152490 
GTF2E2FE | TF2E2 | TFIIE-Bgeneral transcription factor IIE, polypeptide 2, beta 34kDaReconstituted ComplexBioGRID7926747 
GTF2H1BTF2 | TFB1 | TFIIHgeneral transcription factor IIH, polypeptide 1, 62kDaAffinity Capture-Western
Co-purification		BioGRID9118947 |9130708 
|15220921 
-HPRD8194528 |9118947 
GTF2H2BTF2 | BTF2P44 | MGC102806 | T-BTF2P44 | TFIIHgeneral transcription factor IIH, polypeptide 2, 44kDa-HPRD,BioGRID9118947 
GTF2H3BTF2 | TFB4 | TFIIHgeneral transcription factor IIH, polypeptide 3, 34kDa-HPRD,BioGRID9118947 
GTF2H4TFB2 | TFIIHgeneral transcription factor IIH, polypeptide 4, 52kDa-HPRD,BioGRID9118947 
GTF2H5C6orf175 | TFB5 | TGF2H5 | TTD | TTD-A | TTDA | bA120J8.2general transcription factor IIH, polypeptide 5Affinity Capture-Western
Co-purification		BioGRID15220921 
IRF1IRF-1 | MARinterferon regulatory factor 1TFIIH interacts with IRF-1 promoter.BIND15893730 
MNAT1MAT1 | RNF66 | TFB3menage a trois homolog 1, cyclin H assembly factor (Xenopus laevis)-HPRD9118947 
Co-purificationBioGRID15220921 
PSMC5S8 | SUG1 | TBP10 | TRIP1 | p45 | p45/SUGproteasome (prosome, macropain) 26S subunit, ATPase, 5-HPRD,BioGRID9173976 
TAF7TAF2F | TAFII55TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDaTFIIH interacts with TAF7 promoter.BIND15893730 
TP53FLJ92943 | LFS1 | TRP53 | p53tumor protein p53p53 interacts with ERCC3. This interaction was modeled on a demonstrated interaction between human p53 and ERCC3 from an unspecified species.BIND12379483 
-HPRD,BioGRID7663514 
XPCXP3 | XPCCxeroderma pigmentosum, complementation group C-HPRD,BioGRID10734143 
 


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