Gene Page: F11

Summary ?
GeneID2160
SymbolF11
SynonymsFXI
Descriptioncoagulation factor XI
ReferenceMIM:264900|HGNC:HGNC:3529|HPRD:07524|
Gene typeprotein-coding
Map location4q35
Pascal p-value0.502
Fetal beta-0.139
eGeneCaudate basal ganglia
Cortex
Putamen basal ganglia
Meta

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenics,schizophreniasClick to show details
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs22218434187144200F11ENSG00000088926.91.581E-70-42899gtex_brain_putamen_basal
rs100143994187146359F11ENSG00000088926.92.399E-80-40740gtex_brain_putamen_basal
rs42532514187156473F11ENSG00000088926.98.246E-80-30626gtex_brain_putamen_basal
rs283804174187161506F11ENSG00000088926.99.407E-80-25593gtex_brain_putamen_basal
rs42532744187163652F11ENSG00000088926.91.14E-80-23447gtex_brain_putamen_basal
rs42532774187163881F11ENSG00000088926.92.387E-80-23218gtex_brain_putamen_basal
rs1998259824187166964F11ENSG00000088926.97.684E-80-20135gtex_brain_putamen_basal
rs21754944187168782F11ENSG00000088926.91.984E-70-18317gtex_brain_putamen_basal
rs21371454187169266F11ENSG00000088926.92.695E-80-17833gtex_brain_putamen_basal
rs42532994187171355F11ENSG00000088926.91.984E-70-15744gtex_brain_putamen_basal
rs42418214187176834F11ENSG00000088926.91.982E-70-10265gtex_brain_putamen_basal
rs42533264187178599F11ENSG00000088926.93.848E-80-8500gtex_brain_putamen_basal
rs38220554187179678F11ENSG00000088926.91.643E-60-7421gtex_brain_putamen_basal

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
TTC310.930.88
CHTF180.930.93
WDR900.920.91
HAUS50.920.89
LEPRE10.910.90
LIG10.900.89
CNTROB0.900.90
DVL20.900.89
CPSF10.900.90
POLE0.890.91
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
AF347015.31-0.62-0.82
AF347015.27-0.62-0.82
MT-CO2-0.60-0.80
MT-CYB-0.59-0.79
AF347015.33-0.59-0.77
AIFM3-0.58-0.68
AF347015.8-0.58-0.79
C5orf53-0.57-0.67
S100B-0.57-0.72
IFI27-0.57-0.73

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004252serine-type endopeptidase activityNASglutamate (GO term level: 7)9593722 
GO:0008201heparin bindingIEA-
GO:0008233peptidase activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006508proteolysisIEA-
GO:0007596blood coagulationNAS9593722 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005576extracellular regionNAS9593722 
GO:0016020membraneNAS9593722 

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG COMPLEMENT AND COAGULATION CASCADES 6949All SZGR 2.0 genes in this pathway
BIOCARTA INTRINSIC PATHWAY 2315All SZGR 2.0 genes in this pathway
BIOCARTA PLATELETAPP PATHWAY 1410All SZGR 2.0 genes in this pathway
REACTOME FORMATION OF FIBRIN CLOT CLOTTING CASCADE 3222All SZGR 2.0 genes in this pathway
REACTOME INTRINSIC PATHWAY 1712All SZGR 2.0 genes in this pathway
REACTOME HEMOSTASIS 466331All SZGR 2.0 genes in this pathway
PARENT MTOR SIGNALING UP 567375All SZGR 2.0 genes in this pathway
GRUETZMANN PANCREATIC CANCER DN 203134All SZGR 2.0 genes in this pathway
KIM MYCN AMPLIFICATION TARGETS UP 9264All SZGR 2.0 genes in this pathway
HSIAO LIVER SPECIFIC GENES 244154All SZGR 2.0 genes in this pathway
KONDO PROSTATE CANCER WITH H3K27ME3 19693All SZGR 2.0 genes in this pathway
AMUNDSON GAMMA RADIATION RESISTANCE 2014All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER WITH H3K27ME3 UP 295149All SZGR 2.0 genes in this pathway
CHEN METABOLIC SYNDROM NETWORK 1210725All SZGR 2.0 genes in this pathway
CHIANG LIVER CANCER SUBCLASS UNANNOTATED UP 8550All SZGR 2.0 genes in this pathway
YAMASHITA LIVER CANCER STEM CELL DN 7651All SZGR 2.0 genes in this pathway
HOSHIDA LIVER CANCER SUBCLASS S3 266180All SZGR 2.0 genes in this pathway
CAIRO HEPATOBLASTOMA DN 267160All SZGR 2.0 genes in this pathway
CAIRO LIVER DEVELOPMENT DN 222141All SZGR 2.0 genes in this pathway
OHGUCHI LIVER HNF4A TARGETS DN 14985All SZGR 2.0 genes in this pathway
SERVITJA LIVER HNF1A TARGETS DN 157105All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 2ND EGF PULSE ONLY 1725838All SZGR 2.0 genes in this pathway