Gene Page: F11
Summary ?
GeneID | 2160 |
Symbol | F11 |
Synonyms | FXI |
Description | coagulation factor XI |
Reference | MIM:264900|HGNC:HGNC:3529|HPRD:07524| |
Gene type | protein-coding |
Map location | 4q35 |
Pascal p-value | 0.502 |
Fetal beta | -0.139 |
eGene | Caudate basal ganglia Cortex Putamen basal ganglia Meta |
Gene in Data Sources
Gene set name | Method of gene set | Description | Info |
---|---|---|---|
CV:PGCnp | Genome-wide Association Study | GWAS | |
PMID:cooccur | High-throughput literature-search | Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included. | |
Literature | High-throughput literature-search | Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenics,schizophrenias | Click to show details |
GO_Annotation | Mapping neuro-related keywords to Gene Ontology annotations | Hits with neuro-related keywords: 1 |
Section I. Genetics and epigenetics annotation
eQTL annotation
SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
---|---|---|---|---|---|---|---|---|
rs2221843 | 4 | 187144200 | F11 | ENSG00000088926.9 | 1.581E-7 | 0 | -42899 | gtex_brain_putamen_basal |
rs10014399 | 4 | 187146359 | F11 | ENSG00000088926.9 | 2.399E-8 | 0 | -40740 | gtex_brain_putamen_basal |
rs4253251 | 4 | 187156473 | F11 | ENSG00000088926.9 | 8.246E-8 | 0 | -30626 | gtex_brain_putamen_basal |
rs28380417 | 4 | 187161506 | F11 | ENSG00000088926.9 | 9.407E-8 | 0 | -25593 | gtex_brain_putamen_basal |
rs4253274 | 4 | 187163652 | F11 | ENSG00000088926.9 | 1.14E-8 | 0 | -23447 | gtex_brain_putamen_basal |
rs4253277 | 4 | 187163881 | F11 | ENSG00000088926.9 | 2.387E-8 | 0 | -23218 | gtex_brain_putamen_basal |
rs199825982 | 4 | 187166964 | F11 | ENSG00000088926.9 | 7.684E-8 | 0 | -20135 | gtex_brain_putamen_basal |
rs2175494 | 4 | 187168782 | F11 | ENSG00000088926.9 | 1.984E-7 | 0 | -18317 | gtex_brain_putamen_basal |
rs2137145 | 4 | 187169266 | F11 | ENSG00000088926.9 | 2.695E-8 | 0 | -17833 | gtex_brain_putamen_basal |
rs4253299 | 4 | 187171355 | F11 | ENSG00000088926.9 | 1.984E-7 | 0 | -15744 | gtex_brain_putamen_basal |
rs4241821 | 4 | 187176834 | F11 | ENSG00000088926.9 | 1.982E-7 | 0 | -10265 | gtex_brain_putamen_basal |
rs4253326 | 4 | 187178599 | F11 | ENSG00000088926.9 | 3.848E-8 | 0 | -8500 | gtex_brain_putamen_basal |
rs3822055 | 4 | 187179678 | F11 | ENSG00000088926.9 | 1.643E-6 | 0 | -7421 | gtex_brain_putamen_basal |
Section II. Transcriptome annotation
General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
Top 10 positively co-expressed genes | ||
Gene | Pearson's Correlation | Spearman's Correlation |
TTC31 | 0.93 | 0.88 |
CHTF18 | 0.93 | 0.93 |
WDR90 | 0.92 | 0.91 |
HAUS5 | 0.92 | 0.89 |
LEPRE1 | 0.91 | 0.90 |
LIG1 | 0.90 | 0.89 |
CNTROB | 0.90 | 0.90 |
DVL2 | 0.90 | 0.89 |
CPSF1 | 0.90 | 0.90 |
POLE | 0.89 | 0.91 |
Top 10 negatively co-expressed genes | ||
Gene | Pearson's Correlation | Spearman's Correlation |
AF347015.31 | -0.62 | -0.82 |
AF347015.27 | -0.62 | -0.82 |
MT-CO2 | -0.60 | -0.80 |
MT-CYB | -0.59 | -0.79 |
AF347015.33 | -0.59 | -0.77 |
AIFM3 | -0.58 | -0.68 |
AF347015.8 | -0.58 | -0.79 |
C5orf53 | -0.57 | -0.67 |
S100B | -0.57 | -0.72 |
IFI27 | -0.57 | -0.73 |
Section III. Gene Ontology annotation
Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
---|---|---|---|---|
GO:0004252 | serine-type endopeptidase activity | NAS | glutamate (GO term level: 7) | 9593722 |
GO:0008201 | heparin binding | IEA | - | |
GO:0008233 | peptidase activity | IEA | - | |
Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
GO:0006508 | proteolysis | IEA | - | |
GO:0007596 | blood coagulation | NAS | 9593722 | |
Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
GO:0005576 | extracellular region | NAS | 9593722 | |
GO:0016020 | membrane | NAS | 9593722 |
Section V. Pathway annotation
Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
---|---|---|---|
KEGG COMPLEMENT AND COAGULATION CASCADES | 69 | 49 | All SZGR 2.0 genes in this pathway |
BIOCARTA INTRINSIC PATHWAY | 23 | 15 | All SZGR 2.0 genes in this pathway |
BIOCARTA PLATELETAPP PATHWAY | 14 | 10 | All SZGR 2.0 genes in this pathway |
REACTOME FORMATION OF FIBRIN CLOT CLOTTING CASCADE | 32 | 22 | All SZGR 2.0 genes in this pathway |
REACTOME INTRINSIC PATHWAY | 17 | 12 | All SZGR 2.0 genes in this pathway |
REACTOME HEMOSTASIS | 466 | 331 | All SZGR 2.0 genes in this pathway |
PARENT MTOR SIGNALING UP | 567 | 375 | All SZGR 2.0 genes in this pathway |
GRUETZMANN PANCREATIC CANCER DN | 203 | 134 | All SZGR 2.0 genes in this pathway |
KIM MYCN AMPLIFICATION TARGETS UP | 92 | 64 | All SZGR 2.0 genes in this pathway |
HSIAO LIVER SPECIFIC GENES | 244 | 154 | All SZGR 2.0 genes in this pathway |
KONDO PROSTATE CANCER WITH H3K27ME3 | 196 | 93 | All SZGR 2.0 genes in this pathway |
AMUNDSON GAMMA RADIATION RESISTANCE | 20 | 14 | All SZGR 2.0 genes in this pathway |
ACEVEDO LIVER CANCER WITH H3K27ME3 UP | 295 | 149 | All SZGR 2.0 genes in this pathway |
CHEN METABOLIC SYNDROM NETWORK | 1210 | 725 | All SZGR 2.0 genes in this pathway |
CHIANG LIVER CANCER SUBCLASS UNANNOTATED UP | 85 | 50 | All SZGR 2.0 genes in this pathway |
YAMASHITA LIVER CANCER STEM CELL DN | 76 | 51 | All SZGR 2.0 genes in this pathway |
HOSHIDA LIVER CANCER SUBCLASS S3 | 266 | 180 | All SZGR 2.0 genes in this pathway |
CAIRO HEPATOBLASTOMA DN | 267 | 160 | All SZGR 2.0 genes in this pathway |
CAIRO LIVER DEVELOPMENT DN | 222 | 141 | All SZGR 2.0 genes in this pathway |
OHGUCHI LIVER HNF4A TARGETS DN | 149 | 85 | All SZGR 2.0 genes in this pathway |
SERVITJA LIVER HNF1A TARGETS DN | 157 | 105 | All SZGR 2.0 genes in this pathway |
ZWANG TRANSIENTLY UP BY 2ND EGF PULSE ONLY | 1725 | 838 | All SZGR 2.0 genes in this pathway |