Gene Page: F13B
Summary ?
| GeneID | 2165 |
| Symbol | F13B |
| Synonyms | FXIIIB |
| Description | coagulation factor XIII B chain |
| Reference | MIM:134580|HGNC:HGNC:3534|Ensembl:ENSG00000143278|HPRD:00605|Vega:OTTHUMG00000036519 |
| Gene type | protein-coding |
| Map location | 1q31-q32.1 |
| DMG | 1 (# studies) |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DMG:Wockner_2014 | Genome-wide DNA methylation analysis | This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). | 1 |
Section I. Genetics and epigenetics annotation
Differentially methylated gene
| Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
|---|---|---|---|---|---|---|---|
| cg01488306 | 1 | 197037504 | F13B | 3.657E-4 | 0.289 | 0.042 | DMG:Wockner_2014 |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| ANKIB1 | 0.85 | 0.87 |
| FAM108B1 | 0.85 | 0.86 |
| ZDHHC9 | 0.85 | 0.87 |
| FAM120B | 0.84 | 0.86 |
| LRRC8D | 0.84 | 0.86 |
| COPA | 0.83 | 0.84 |
| HECTD1 | 0.83 | 0.84 |
| UBE4A | 0.83 | 0.85 |
| ZBTB38 | 0.83 | 0.85 |
| RABGEF1 | 0.83 | 0.82 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| AF347015.21 | -0.71 | -0.73 |
| AF347015.31 | -0.69 | -0.69 |
| MT-CO2 | -0.68 | -0.69 |
| IFI27 | -0.67 | -0.67 |
| CXCL14 | -0.66 | -0.66 |
| PLA2G5 | -0.66 | -0.69 |
| HIGD1B | -0.66 | -0.66 |
| CST3 | -0.65 | -0.67 |
| AF347015.8 | -0.64 | -0.67 |
| FXYD1 | -0.64 | -0.64 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KEGG COMPLEMENT AND COAGULATION CASCADES | 69 | 49 | All SZGR 2.0 genes in this pathway |
| REACTOME COMMON PATHWAY | 14 | 10 | All SZGR 2.0 genes in this pathway |
| REACTOME FORMATION OF FIBRIN CLOT CLOTTING CASCADE | 32 | 22 | All SZGR 2.0 genes in this pathway |
| REACTOME HEMOSTASIS | 466 | 331 | All SZGR 2.0 genes in this pathway |
| GRANDVAUX IRF3 TARGETS UP | 15 | 12 | All SZGR 2.0 genes in this pathway |
| HSIAO LIVER SPECIFIC GENES | 244 | 154 | All SZGR 2.0 genes in this pathway |
| ACEVEDO LIVER CANCER UP | 973 | 570 | All SZGR 2.0 genes in this pathway |
| ACEVEDO LIVER TUMOR VS NORMAL ADJACENT TISSUE UP | 863 | 514 | All SZGR 2.0 genes in this pathway |
| BOCHKIS FOXA2 TARGETS | 425 | 261 | All SZGR 2.0 genes in this pathway |
| LEE LIVER CANCER SURVIVAL UP | 185 | 112 | All SZGR 2.0 genes in this pathway |
| OHGUCHI LIVER HNF4A TARGETS DN | 149 | 85 | All SZGR 2.0 genes in this pathway |
| SERVITJA LIVER HNF1A TARGETS DN | 157 | 105 | All SZGR 2.0 genes in this pathway |
| RAO BOUND BY SALL4 ISOFORM B | 517 | 302 | All SZGR 2.0 genes in this pathway |
| NABA ECM REGULATORS | 238 | 125 | All SZGR 2.0 genes in this pathway |
| NABA MATRISOME ASSOCIATED | 753 | 411 | All SZGR 2.0 genes in this pathway |
| NABA MATRISOME | 1028 | 559 | All SZGR 2.0 genes in this pathway |