Gene Page: FANCA
Summary ?
GeneID | 2175 |
Symbol | FANCA |
Synonyms | FA|FA-H|FA1|FAA|FACA|FAH|FANCH |
Description | Fanconi anemia complementation group A |
Reference | MIM:607139|HGNC:HGNC:3582|Ensembl:ENSG00000187741|HPRD:06186|Vega:OTTHUMG00000173049 |
Gene type | protein-coding |
Map location | 16q24.3 |
Pascal p-value | 3.312E-5 |
Sherlock p-value | 0.81 |
eGene | Myers' cis & trans |
Gene in Data Sources
Gene set name | Method of gene set | Description | Info |
---|---|---|---|
CV:PGCnp | Genome-wide Association Study | GWAS |
Section I. Genetics and epigenetics annotation
eQTL annotation
SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
---|---|---|---|---|---|---|---|---|
rs4141780 | chr20 | 40297792 | FANCA | 2175 | 0.19 | trans |
Section II. Transcriptome annotation
General gene expression (GTEx)

Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section IV. Protein-protein interaction annotation
Interactors | Aliases B | Official full name B | Experimental | Source | PubMed ID |
---|---|---|---|---|---|
AKT1 | AKT | MGC99656 | PKB | PKB-ALPHA | PRKBA | RAC | RAC-ALPHA | v-akt murine thymoma viral oncogene homolog 1 | Two-hybrid | BioGRID | 14499622 |
ALDOA | ALDA | MGC10942 | MGC17716 | MGC17767 | aldolase A, fructose-bisphosphate | Two-hybrid | BioGRID | 14499622 |
ATP5B | ATPMB | ATPSB | MGC5231 | ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide | Two-hybrid | BioGRID | 14499622 |
AZIN1 | MGC3832 | MGC691 | OAZI | OAZIN | ODC1L | antizyme inhibitor 1 | Two-hybrid | BioGRID | 14499622 |
BAT1 | D6S81E | DDX39B | UAP56 | HLA-B associated transcript 1 | Two-hybrid | BioGRID | 14499622 |
BLM | BS | MGC126616 | MGC131618 | MGC131620 | RECQ2 | RECQL2 | RECQL3 | Bloom syndrome | Affinity Capture-MS | BioGRID | 12973351 |
BRCA1 | BRCAI | BRCC1 | IRIS | PSCP | RNF53 | breast cancer 1, early onset | BRCA1 interacts with FANCA. | BIND | 12354784 |
BRCA1 | BRCAI | BRCC1 | IRIS | PSCP | RNF53 | breast cancer 1, early onset | - | HPRD,BioGRID | 12354784 |
CCT3 | CCT-gamma | CCTG | PIG48 | TCP-1-gamma | TRIC5 | chaperonin containing TCP1, subunit 3 (gamma) | Two-hybrid | BioGRID | 14499622 |
CD52 | CDW52 | CD52 molecule | in vivo | BioGRID | 6186 |
CD79A | IGA | MB-1 | CD79a molecule, immunoglobulin-associated alpha | Two-hybrid | BioGRID | 14499622 |
CDC2 | CDC28A | CDK1 | DKFZp686L20222 | MGC111195 | cell division cycle 2, G1 to S and G2 to M | Affinity Capture-MS | BioGRID | 15082718 |
CHUK | IKBKA | IKK-alpha | IKK1 | IKKA | NFKBIKA | TCF16 | conserved helix-loop-helix ubiquitous kinase | Affinity Capture-Western Two-hybrid | BioGRID | 12210728 |14499622 |
DAXX | BING2 | DAP6 | EAP1 | MGC126245 | MGC126246 | death-domain associated protein | Two-hybrid | BioGRID | 14499622 |
DNAJB1 | HSPF1 | Hdj1 | Hsp40 | Sis1 | DnaJ (Hsp40) homolog, subfamily B, member 1 | Two-hybrid | BioGRID | 14499622 |
DUS4L | DUS4 | MGC133233 | PP35 | dihydrouridine synthase 4-like (S. cerevisiae) | Two-hybrid | BioGRID | 14499622 |
ENO1 | ENO1L1 | MBP-1 | MPB1 | NNE | PPH | enolase 1, (alpha) | Two-hybrid | BioGRID | 14499622 |
ERCC4 | RAD1 | XPF | excision repair cross-complementing rodent repair deficiency, complementation group 4 | Affinity Capture-Western | BioGRID | 12571280 |
FANCA | FA | FA-H | FA1 | FAA | FACA | FAH | FANCH | MGC75158 | Fanconi anemia, complementation group A | Affinity Capture-MS Affinity Capture-Western Two-hybrid | BioGRID | 9742112 |10652215 |11157805 |12973351 |
FANCA | FA | FA-H | FA1 | FAA | FACA | FAH | FANCH | MGC75158 | Fanconi anemia, complementation group A | FANCA interacts with FANCA. | BIND | 15138265 |
FANCC | FA3 | FAC | FACC | FLJ14675 | Fanconi anemia, complementation group C | Affinity Capture-MS Affinity Capture-Western Reconstituted Complex Two-hybrid | BioGRID | 10373536 |10551855 |10627486 |10961856 |11063725 |12210728 |12239156 |12973351 |15082718 |
FANCC | FA3 | FAC | FACC | FLJ14675 | Fanconi anemia, complementation group C | - | HPRD | 9742112 |
FANCE | FACE | FAE | Fanconi anemia, complementation group E | - | HPRD | 11157805 |12239156 |
FANCE | FACE | FAE | Fanconi anemia, complementation group E | Affinity Capture-MS Affinity Capture-Western Reconstituted Complex Two-hybrid | BioGRID | 11157805 |12093742 |12239156 |12973351 |
FANCF | FAF | MGC126856 | Fanconi anemia, complementation group F | - | HPRD,BioGRID | 11063725 |
FANCG | FAG | XRCC9 | Fanconi anemia, complementation group G | FANCA interacts with FANCG. | BIND | 15138265 |
FANCG | FAG | XRCC9 | Fanconi anemia, complementation group G | - | HPRD | 10468603 |11050007 |
FANCG | FAG | XRCC9 | Fanconi anemia, complementation group G | Affinity Capture-MS Affinity Capture-Western Co-purification in vitro in vivo Reconstituted Complex Two-hybrid | BioGRID | 10373536 |10468603 |10468606 |10567393 |10627486 |10652215 |10961856 |11050007 |11157805 |11739169 |11918676 |12210728 |12239156 |12649160 |12973351 |14697762 |15082718 |15138265 |16189514 |
FANCL | FAAP43 | FLJ10335 | PHF9 | POG | Fanconi anemia, complementation group L | Affinity Capture-MS | BioGRID | 12973351 |
GNB2 | - | guanine nucleotide binding protein (G protein), beta polypeptide 2 | Two-hybrid | BioGRID | 14499622 |
HPRT1 | HGPRT | HPRT | hypoxanthine phosphoribosyltransferase 1 | Two-hybrid | BioGRID | 14499622 |
HSP90AA1 | FLJ31884 | HSP86 | HSP89A | HSP90A | HSP90N | HSPC1 | HSPCA | HSPCAL1 | HSPCAL4 | HSPN | Hsp89 | Hsp90 | LAP2 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | Two-hybrid | BioGRID | 14499622 |
HSP90B1 | ECGP | GP96 | GRP94 | TRA1 | heat shock protein 90kDa beta (Grp94), member 1 | Affinity Capture-MS | BioGRID | 15082718 |
IFIT3 | CIG-49 | GARG-49 | IFI60 | IFIT4 | IRG2 | ISG60 | RIG-G | interferon-induced protein with tetratricopeptide repeats 3 | Two-hybrid | BioGRID | 14499622 |
IKBKB | FLJ40509 | IKK-beta | IKK2 | IKKB | MGC131801 | NFKBIKB | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta | - | HPRD,BioGRID | 12210728 |
KRT1 | CK1 | EHK1 | K1 | KRT1A | keratin 1 | Two-hybrid | BioGRID | 14499622 |
LIPG | EDL | EL | PRO719 | lipase, endothelial | Two-hybrid | BioGRID | 14499622 |
MKNK1 | MNK1 | MAP kinase interacting serine/threonine kinase 1 | Two-hybrid | BioGRID | 14499622 |
MX1 | IFI-78K | IFI78 | MX | MxA | myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse) | Two-hybrid | BioGRID | 14499622 |
NAMPT | 1110035O14Rik | DKFZp666B131 | MGC117256 | PBEF | PBEF1 | VF | VISFATIN | nicotinamide phosphoribosyltransferase | Two-hybrid | BioGRID | 14499622 |
NUB1 | BS4 | NUB1L | NYREN18 | negative regulator of ubiquitin-like proteins 1 | Two-hybrid | BioGRID | 14499622 |
PRPF31 | DKFZp566J153 | NY-BR-99 | PRP31 | RP11 | PRP31 pre-mRNA processing factor 31 homolog (S. cerevisiae) | Two-hybrid | BioGRID | 14499622 |
PSMA5 | MGC117302 | MGC125802 | MGC125803 | MGC125804 | PSC5 | ZETA | proteasome (prosome, macropain) subunit, alpha type, 5 | Two-hybrid | BioGRID | 14499622 |
RMI1 | BLAP75 | C9orf76 | FLJ12888 | RP11-346I8.1 | RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae) | Affinity Capture-MS | BioGRID | 12973351 |
RPA1 | HSSB | REPA1 | RF-A | RP-A | RPA70 | replication protein A1, 70kDa | Affinity Capture-MS | BioGRID | 12973351 |
RPL18 | - | ribosomal protein L18 | Two-hybrid | BioGRID | 14499622 |
SGK1 | SGK | serum/glucocorticoid regulated kinase 1 | Two-hybrid | BioGRID | 14499622 |
SMARCA4 | BAF190 | BRG1 | FLJ39786 | SNF2 | SNF2-BETA | SNF2L4 | SNF2LB | SWI2 | hSNF2b | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 | - | HPRD,BioGRID | 11726552 |
SMARCC1 | BAF155 | CRACC1 | Rsc8 | SRG3 | SWI3 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 | - | HPRD | 11726552 |
SMARCD3 | BAF60C | CRACD3 | MGC111010 | Rsc6p | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3 | - | HPRD | 11726552 |
SNX5 | FLJ10931 | sorting nexin 5 | - | HPRD,BioGRID | 10600472 |
SPTA1 | EL2 | SPTA | spectrin, alpha, erythrocytic 1 (elliptocytosis 2) | Affinity Capture-Western | BioGRID | 12571280 |
SPTAN1 | (ALPHA)II-SPECTRIN | FLJ44613 | NEAS | spectrin, alpha, non-erythrocytic 1 (alpha-fodrin) | Affinity Capture-Western Co-purification | BioGRID | 10551855 |11401546 |12571280 |
TAF10 | TAF2A | TAF2H | TAFII30 | TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa | Two-hybrid | BioGRID | 14499622 |
TCERG1 | CA150 | MGC133200 | TAF2S | transcription elongation regulator 1 | Two-hybrid | BioGRID | 14499622 |
TCP1 | CCT-alpha | CCT1 | CCTa | D6S230E | TCP-1-alpha | t-complex 1 | Two-hybrid | BioGRID | 14499622 |
TOP3A | TOP3 | topoisomerase (DNA) III alpha | Affinity Capture-MS | BioGRID | 12973351 |
TPT1 | FLJ27337 | HRF | TCTP | p02 | tumor protein, translationally-controlled 1 | Two-hybrid | BioGRID | 14499622 |
ZNF24 | KOX17 | RSG-A | ZNF191 | ZSCAN3 | Zfp191 | zinc finger protein 24 | Two-hybrid | BioGRID | 14499622 |
Section V. Pathway annotation
Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
---|---|---|---|
PID FANCONI PATHWAY | 47 | 28 | All SZGR 2.0 genes in this pathway |
PID BARD1 PATHWAY | 29 | 19 | All SZGR 2.0 genes in this pathway |
REACTOME FANCONI ANEMIA PATHWAY | 25 | 11 | All SZGR 2.0 genes in this pathway |
REACTOME DNA REPAIR | 112 | 59 | All SZGR 2.0 genes in this pathway |
HOLLMANN APOPTOSIS VIA CD40 UP | 201 | 125 | All SZGR 2.0 genes in this pathway |
GINESTIER BREAST CANCER ZNF217 AMPLIFIED DN | 335 | 193 | All SZGR 2.0 genes in this pathway |
MULLIGHAN NPM1 SIGNATURE 3 UP | 341 | 197 | All SZGR 2.0 genes in this pathway |
KINSEY TARGETS OF EWSR1 FLII FUSION UP | 1278 | 748 | All SZGR 2.0 genes in this pathway |
CHIN BREAST CANCER COPY NUMBER DN | 16 | 10 | All SZGR 2.0 genes in this pathway |
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN | 1781 | 1082 | All SZGR 2.0 genes in this pathway |
ROYLANCE BREAST CANCER 16Q COPY NUMBER UP | 63 | 44 | All SZGR 2.0 genes in this pathway |
MATHEW FANCONI ANEMIA GENES | 11 | 7 | All SZGR 2.0 genes in this pathway |
SCHEIDEREIT IKK INTERACTING PROTEINS | 58 | 45 | All SZGR 2.0 genes in this pathway |
SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN UP | 479 | 299 | All SZGR 2.0 genes in this pathway |
PUJANA BREAST CANCER LIT INT NETWORK | 101 | 73 | All SZGR 2.0 genes in this pathway |
PUJANA BRCA2 PCC NETWORK | 423 | 265 | All SZGR 2.0 genes in this pathway |
KAUFFMANN MELANOMA RELAPSE UP | 61 | 25 | All SZGR 2.0 genes in this pathway |
NUYTTEN EZH2 TARGETS DN | 1024 | 594 | All SZGR 2.0 genes in this pathway |
BUYTAERT PHOTODYNAMIC THERAPY STRESS DN | 637 | 377 | All SZGR 2.0 genes in this pathway |
LOPEZ MBD TARGETS | 957 | 597 | All SZGR 2.0 genes in this pathway |
BENPORATH NANOG TARGETS | 988 | 594 | All SZGR 2.0 genes in this pathway |
BENPORATH CYCLING GENES | 648 | 385 | All SZGR 2.0 genes in this pathway |
BENPORATH PROLIFERATION | 147 | 80 | All SZGR 2.0 genes in this pathway |
SHIN B CELL LYMPHOMA CLUSTER 2 | 30 | 23 | All SZGR 2.0 genes in this pathway |
KAUFFMANN DNA REPAIR GENES | 230 | 137 | All SZGR 2.0 genes in this pathway |
NIKOLSKY BREAST CANCER 16Q24 AMPLICON | 53 | 38 | All SZGR 2.0 genes in this pathway |
NIKOLSKY MUTATED AND AMPLIFIED IN BREAST CANCER | 94 | 60 | All SZGR 2.0 genes in this pathway |
VERNELL RETINOBLASTOMA PATHWAY UP | 70 | 47 | All SZGR 2.0 genes in this pathway |
DEBIASI APOPTOSIS BY REOVIRUS INFECTION DN | 287 | 208 | All SZGR 2.0 genes in this pathway |
BILD E2F3 ONCOGENIC SIGNATURE | 246 | 153 | All SZGR 2.0 genes in this pathway |
MARSON BOUND BY E2F4 UNSTIMULATED | 728 | 415 | All SZGR 2.0 genes in this pathway |
SANSOM APC TARGETS REQUIRE MYC | 210 | 123 | All SZGR 2.0 genes in this pathway |
SMID BREAST CANCER BASAL UP | 648 | 398 | All SZGR 2.0 genes in this pathway |
MATZUK MEIOTIC AND DNA REPAIR | 39 | 26 | All SZGR 2.0 genes in this pathway |
MATZUK SPERMATOCYTE | 72 | 55 | All SZGR 2.0 genes in this pathway |
GRADE COLON CANCER UP | 871 | 505 | All SZGR 2.0 genes in this pathway |
BLUM RESPONSE TO SALIRASIB DN | 342 | 220 | All SZGR 2.0 genes in this pathway |
GRESHOCK CANCER COPY NUMBER UP | 323 | 240 | All SZGR 2.0 genes in this pathway |
BOYLAN MULTIPLE MYELOMA C D UP | 139 | 95 | All SZGR 2.0 genes in this pathway |
VANTVEER BREAST CANCER ESR1 DN | 240 | 153 | All SZGR 2.0 genes in this pathway |
SHEDDEN LUNG CANCER POOR SURVIVAL A6 | 456 | 285 | All SZGR 2.0 genes in this pathway |
ZHANG TLX TARGETS 36HR DN | 185 | 116 | All SZGR 2.0 genes in this pathway |
ZHANG TLX TARGETS 60HR DN | 277 | 166 | All SZGR 2.0 genes in this pathway |
ZHANG TLX TARGETS DN | 89 | 50 | All SZGR 2.0 genes in this pathway |
HOSHIDA LIVER CANCER SUBCLASS S3 | 266 | 180 | All SZGR 2.0 genes in this pathway |
CAIRO HEPATOBLASTOMA CLASSES UP | 605 | 377 | All SZGR 2.0 genes in this pathway |
WHITFIELD CELL CYCLE S | 162 | 86 | All SZGR 2.0 genes in this pathway |
DUTERTRE ESTRADIOL RESPONSE 24HR UP | 324 | 193 | All SZGR 2.0 genes in this pathway |
LEE BMP2 TARGETS DN | 882 | 538 | All SZGR 2.0 genes in this pathway |
GOBERT OLIGODENDROCYTE DIFFERENTIATION UP | 570 | 339 | All SZGR 2.0 genes in this pathway |
KATSANOU ELAVL1 TARGETS DN | 148 | 88 | All SZGR 2.0 genes in this pathway |