Gene Page: FANCG

Summary ?
GeneID2189
SymbolFANCG
SynonymsFAG|XRCC9
DescriptionFanconi anemia complementation group G
ReferenceMIM:602956|HGNC:HGNC:3588|Ensembl:ENSG00000221829|HPRD:04262|Vega:OTTHUMG00000019850
Gene typeprotein-coding
Map location9p13
Pascal p-value0.008
Sherlock p-value0.331
Fetal beta0.87
DMG1 (# studies)
eGeneCerebellum
Myers' cis & trans

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Jaffe_2016Genome-wide DNA methylation analysisThis dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 1

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg03563403935079882FANCG9.47E-11-0.014.49E-7DMG:Jaffe_2016

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs16829545chr2151977407FANCG21891.658E-8trans
rs17762315chr576807576FANCG21890.02trans
rs16955618chr1529937543FANCG21893.699E-7trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
BRCA2BRCC2 | FACD | FAD | FAD1 | FANCB | FANCD | FANCD1breast cancer 2, early onsetAffinity Capture-Western
Two-hybrid		BioGRID12915460 
BRCA2BRCC2 | FACD | FAD | FAD1 | FANCB | FANCD | FANCD1breast cancer 2, early onsetFANCG interacts with BRCA2.BIND12915460 
CDC2CDC28A | CDK1 | DKFZp686L20222 | MGC111195cell division cycle 2, G1 to S and G2 to MReconstituted ComplexBioGRID15367677 
CYP19A1ARO | ARO1 | CPV1 | CYAR | CYP19 | MGC104309 | P-450AROMcytochrome P450, family 19, subfamily A, polypeptide 1-HPRD11756225 
CYP2E1CPE1 | CYP2E | P450-J | P450C2Ecytochrome P450, family 2, subfamily E, polypeptide 1Two-hybridBioGRID14499622 
FANCAFA | FA-H | FA1 | FAA | FACA | FAH | FANCH | MGC75158Fanconi anemia, complementation group AFANCA interacts with FANCG.BIND15138265 
FANCAFA | FA-H | FA1 | FAA | FACA | FAH | FANCH | MGC75158Fanconi anemia, complementation group A-HPRD10468603 |11050007 
FANCAFA | FA-H | FA1 | FAA | FACA | FAH | FANCH | MGC75158Fanconi anemia, complementation group AAffinity Capture-MS
Affinity Capture-Western
Co-purification
in vitro
in vivo
Reconstituted Complex
Two-hybrid		BioGRID10373536 |10468603 
|10468606 |10567393 
|10627486 |10652215 
|10961856 |11050007 
|11157805 |11739169 
|11918676 |12210728 
|12239156 |12649160 
|12973351 |14697762 
|15082718 |15138265 
|16189514 
FANCCFA3 | FAC | FACC | FLJ14675Fanconi anemia, complementation group C-HPRD,BioGRID10373536 
FANCEFACE | FAEFanconi anemia, complementation group E-HPRD11157805 |12239156 
FANCEFACE | FAEFanconi anemia, complementation group EAffinity Capture-Western
Reconstituted Complex
Two-hybrid		BioGRID11157805 |12093742 
|12239156 
FANCFFAF | MGC126856Fanconi anemia, complementation group F-HPRD,BioGRID11063725 |11157805 
FANCGFAG | XRCC9Fanconi anemia, complementation group GFANCG interacts with FANCG.BIND15138265 
FANCGFAG | XRCC9Fanconi anemia, complementation group GCo-purification
Two-hybrid		BioGRID10652215 |11157805 
|15138265 
GABPB1BABPB2 | E4TF1 | E4TF1-47 | E4TF1-53 | E4TF1B | GABPB | GABPB2 | NRF2B1 | NRF2B2GA binding protein transcription factor, beta subunit 1Two-hybridBioGRID16189514 
KRT19CK19 | K19 | K1CS | MGC15366keratin 19Two-hybridBioGRID16189514 
PSMB1FLJ25321 | HC5 | KIAA1838 | PMSB1 | PSC5proteasome (prosome, macropain) subunit, beta type, 1Two-hybridBioGRID14499622 
RTN2NSP2 | NSPL1reticulon 2Two-hybridBioGRID14499622 
SAMD3FLJ34563 | MGC35163sterile alpha motif domain containing 3Two-hybridBioGRID16189514 
SPTAN1(ALPHA)II-SPECTRIN | FLJ44613 | NEASspectrin, alpha, non-erythrocytic 1 (alpha-fodrin)Co-purificationBioGRID11401546 
USHBP1AIEBP | FLJ38709 | FLJ90681 | MCC2Usher syndrome 1C binding protein 1Two-hybridBioGRID16189514 
ZBED1ALTE | DREF | KIAA0785 | TRAMP | hDREFzinc finger, BED-type containing 1Two-hybridBioGRID16189514 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
BIOCARTA ATRBRCA PATHWAY 2112All SZGR 2.0 genes in this pathway
PID FANCONI PATHWAY 4728All SZGR 2.0 genes in this pathway
PID BARD1 PATHWAY 2919All SZGR 2.0 genes in this pathway
REACTOME FANCONI ANEMIA PATHWAY 2511All SZGR 2.0 genes in this pathway
REACTOME DNA REPAIR 11259All SZGR 2.0 genes in this pathway
PARENT MTOR SIGNALING UP 567375All SZGR 2.0 genes in this pathway
SENESE HDAC3 TARGETS DN 536332All SZGR 2.0 genes in this pathway
KINSEY TARGETS OF EWSR1 FLII FUSION UP 1278748All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA DN 1375806All SZGR 2.0 genes in this pathway
KOKKINAKIS METHIONINE DEPRIVATION 48HR UP 12895All SZGR 2.0 genes in this pathway
KOKKINAKIS METHIONINE DEPRIVATION 96HR UP 11784All SZGR 2.0 genes in this pathway
CHOW RASSF1 TARGETS UP 2717All SZGR 2.0 genes in this pathway
WAKASUGI HAVE ZNF143 BINDING SITES 5833All SZGR 2.0 genes in this pathway
MATHEW FANCONI ANEMIA GENES 117All SZGR 2.0 genes in this pathway
PATIL LIVER CANCER 747453All SZGR 2.0 genes in this pathway
PUJANA BREAST CANCER LIT INT NETWORK 10173All SZGR 2.0 genes in this pathway
PUJANA BRCA2 PCC NETWORK 423265All SZGR 2.0 genes in this pathway
KAUFFMANN MELANOMA RELAPSE UP 6125All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS DN 1024594All SZGR 2.0 genes in this pathway
BENPORATH CYCLING GENES 648385All SZGR 2.0 genes in this pathway
SHIN B CELL LYMPHOMA CLUSTER 8 3628All SZGR 2.0 genes in this pathway
KAUFFMANN DNA REPAIR GENES 230137All SZGR 2.0 genes in this pathway
MANALO HYPOXIA DN 289166All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL FLI1 98All SZGR 2.0 genes in this pathway
PENG RAPAMYCIN RESPONSE UP 203130All SZGR 2.0 genes in this pathway
ZHANG RESPONSE TO CANTHARIDIN DN 6946All SZGR 2.0 genes in this pathway
CHANG IMMORTALIZED BY HPV31 UP 8455All SZGR 2.0 genes in this pathway
WANG CISPLATIN RESPONSE AND XPC UP 202115All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 4 307185All SZGR 2.0 genes in this pathway
MARSON BOUND BY E2F4 UNSTIMULATED 728415All SZGR 2.0 genes in this pathway
MITSIADES RESPONSE TO APLIDIN DN 249165All SZGR 2.0 genes in this pathway
MATZUK MEIOTIC AND DNA REPAIR 3926All SZGR 2.0 genes in this pathway
GRESHOCK CANCER COPY NUMBER UP 323240All SZGR 2.0 genes in this pathway
CHANG CYCLING GENES 14883All SZGR 2.0 genes in this pathway
WHITFIELD CELL CYCLE G1 S 14776All SZGR 2.0 genes in this pathway
CHICAS RB1 TARGETS SENESCENT 572352All SZGR 2.0 genes in this pathway
DUTERTRE ESTRADIOL RESPONSE 24HR UP 324193All SZGR 2.0 genes in this pathway