Gene Page: TDRD6
Summary ?
| GeneID | 221400 |
| Symbol | TDRD6 |
| Synonyms | CT41.2|NY-CO-45|SPATA36|TDR2|bA446F17.4 |
| Description | tudor domain containing 6 |
| Reference | MIM:611200|HGNC:HGNC:21339|Ensembl:ENSG00000180113|HPRD:18172| |
| Gene type | protein-coding |
| Map location | 6p12.3 |
| Pascal p-value | 0.045 |
| eGene | Caudate basal ganglia Cerebellar Hemisphere Cerebellum Cortex Frontal Cortex BA9 Hippocampus Hypothalamus Nucleus accumbens basal ganglia Putamen basal ganglia Meta |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| GSMA_IIE | Genome scan meta-analysis (European-ancestry samples) | Psr: 0.04433 |
Section I. Genetics and epigenetics annotation
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs7739815 | 6 | 46624656 | TDRD6 | ENSG00000180113.11 | 2.19024E-7 | 0.01 | -30956 | gtex_brain_putamen_basal |
| rs2270450 | 6 | 46644875 | TDRD6 | ENSG00000180113.11 | 2.1919E-7 | 0.01 | -10737 | gtex_brain_putamen_basal |
| rs34964632 | 6 | 46648129 | TDRD6 | ENSG00000180113.11 | 2.1919E-7 | 0.01 | -7483 | gtex_brain_putamen_basal |
| rs6899519 | 6 | 46681900 | TDRD6 | ENSG00000180113.11 | 2.1919E-7 | 0.01 | 26288 | gtex_brain_putamen_basal |
| rs1805017 | 6 | 46684222 | TDRD6 | ENSG00000180113.11 | 2.1919E-7 | 0.01 | 28610 | gtex_brain_putamen_basal |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section III. Gene Ontology annotation
| Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0003676 | nucleic acid binding | IEA | - |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| URS ADIPOCYTE DIFFERENTIATION UP | 74 | 51 | All SZGR 2.0 genes in this pathway |
| ACEVEDO METHYLATED IN LIVER CANCER DN | 940 | 425 | All SZGR 2.0 genes in this pathway |
| MEISSNER NPC HCP WITH H3 UNMETHYLATED | 536 | 296 | All SZGR 2.0 genes in this pathway |
| MEISSNER BRAIN HCP WITH H3K27ME3 | 269 | 159 | All SZGR 2.0 genes in this pathway |
| MIKKELSEN MCV6 HCP WITH H3K27ME3 | 435 | 318 | All SZGR 2.0 genes in this pathway |