Gene Page: FOXK1

Summary ?
GeneID221937
SymbolFOXK1
SynonymsFOXK1L
Descriptionforkhead box K1
ReferenceMIM:616302|HGNC:HGNC:23480|Ensembl:ENSG00000164916|HPRD:18750|Vega:OTTHUMG00000151739
Gene typeprotein-coding
Map location7p22.1
Pascal p-value0.047
Fetal beta-0.402
DMG1 (# studies)

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:GWASdbGenome-wide Association StudiesGWASdb records for schizophrenia
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Wockner_2014Genome-wide DNA methylation analysisThis dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg0764275474763655FOXK13.1E-50.6090.019DMG:Wockner_2014


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003700transcription factor activityIEA-
GO:0005515protein bindingIEA-
GO:0016564transcription repressor activityIEA-
GO:0016563transcription activator activityIEA-
GO:0043565sequence-specific DNA bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007519skeletal muscle developmentIEAneuron (GO term level: 8)-
GO:0006357regulation of transcription from RNA polymerase II promoterIEA-
GO:0006350transcriptionIEA-
GO:0007275multicellular organismal developmentIEA-
GO:0030154cell differentiationIEA-
GO:0045892negative regulation of transcription, DNA-dependentIEA-
GO:0045893positive regulation of transcription, DNA-dependentIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusIEA-

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
WANG CLIM2 TARGETS DN 186114All SZGR 2.0 genes in this pathway
NIKOLSKY BREAST CANCER 7P22 AMPLICON 3827All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS EARLY PROGENITOR 532309All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN 19721213All SZGR 2.0 genes in this pathway
LINSLEY MIR16 TARGETS 206127All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-1555295351Ahsa-miR-155UUAAUGCUAAUCGUGAUAGGGG
miR-18184778483m8hsa-miR-181abrainAACAUUCAACGCUGUCGGUGAGU
hsa-miR-181bSZAACAUUCAUUGCUGUCGGUGGG
hsa-miR-181cbrainAACAUUCAACCUGUCGGUGAGU
hsa-miR-181dbrainAACAUUCAUUGUUGUCGGUGGGUU
miR-200bc/42984288434m8hsa-miR-200bUAAUACUGCCUGGUAAUGAUGAC
hsa-miR-200cUAAUACUGCCGGGUAAUGAUGG
hsa-miR-429UAAUACUGUCUGGUAAAACCGU
miR-203.1841284181Ahsa-miR-203UGAAAUGUUUAGGACCACUAG
miR-2384798485m8hsa-miR-23abrainAUCACAUUGCCAGGGAUUUCC
hsa-miR-23bbrainAUCACAUUGCCAGGGAUUACC
miR-323847984851Ahsa-miR-323brainGCACAUUACACGGUCGACCUCU
miR-3655285341Ahsa-miR-365UAAUGCCCCUAAAAAUCCUUAU
miR-485-3p214220m8hsa-miR-485-3pGUCAUACACGGCUCUCCUCUCU