Gene Page: FGD1

Summary
GeneID  2245
Symbol  FGD1
Synonyms  AAS|FGDY|ZFYVE3
Description  FYVE, RhoGEF and PH domain containing 1
See related  HGNC:3663|MIM:300546|Ensembl:ENSG00000102302|HPRD:02373|
Locus tag  RP1-112K5.1
Gene type  protein-coding
Map location  Xp11.21
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.6708 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
PLEKHG10.740.79
ASAP30.720.83
ZBTB200.680.57
WNT5A0.680.58
PSKH10.680.70
ZNF6870.670.71
COL2A10.660.34
BOC0.650.68
NOTCH20.650.79
BMP70.650.69
Top 10 negatively co-expressed genes
SYCP3-0.33-0.37
AL050337.1-0.32-0.39
GPR160-0.31-0.34
LY96-0.30-0.29
AF347015.21-0.30-0.31
CLEC2B-0.29-0.29
USMG5-0.29-0.39
RERGL-0.29-0.30
TTC9B-0.29-0.36
DDTL-0.28-0.36
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005089Rho guanyl-nucleotide exchange factor activityIEA-
GO:0005085guanyl-nucleotide exchange factor activityIDA8969170 
GO:0005515protein bindingISS-
GO:0008270zinc ion bindingIEA-
GO:0031267small GTPase bindingIDA8969170 
GO:0046872metal ion bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0046847filopodium formationIDAaxon (GO term level: 10)8969170 
GO:0007010cytoskeleton organizationISS-
GO:0009887organ morphogenesisTAS7954831 
GO:0007165signal transductionTAS8969170 
GO:0008360regulation of cell shapeISS-
GO:0007275multicellular organismal developmentTAS8969170 
GO:0030036actin cytoskeleton organizationIDA8969170 
GO:0035023regulation of Rho protein signal transductionIEA-
GO:0043088regulation of Cdc42 GTPase activityIDA8969170 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0001726ruffleISS-
GO:0005794Golgi apparatusISS-
GO:0005856cytoskeletonIEA-
GO:0005622intracellularIEA-
GO:0005634nucleusIDA18029348 
GO:0005737cytoplasmISS-
GO:0030027lamellipodiumISS-
GO:0005886plasma membraneIDA18029348 
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CDC42CDC42Hs | G25Kcell division cycle 42 (GTP binding protein, 25kDa)-HPRD,BioGRID8969170 
CTTNEMS1 | FLJ34459cortactin-HPRD12913069 
ELMO1CED-12 | CED12 | ELMO-1 | KIAA0281 | MGC126406engulfment and cell motility 1-HPRD12134158 
 
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-17-5p/20/93.mr/106/519.d113119m8hsa-miR-17-5pCAAAGUGCUUACAGUGCAGGUAGU
hsa-miR-20abrainUAAAGUGCUUAUAGUGCAGGUAG
hsa-miR-106aAAAAGUGCUUACAGUGCAGGUAGC
hsa-miR-106bSZUAAAGUGCUGACAGUGCAGAU
hsa-miR-20bSZCAAAGUGCUCAUAGUGCAGGUAG
hsa-miR-519dCAAAGUGCCUCCCUUUAGAGUGU
miR-200bc/429510516m8hsa-miR-200bUAAUACUGCCUGGUAAUGAUGAC
hsa-miR-200cUAAUACUGCCGGGUAAUGAUGG
hsa-miR-429UAAUACUGUCUGGUAAAACCGU
miR-26931001A,m8hsa-miR-26abrainUUCAAGUAAUCCAGGAUAGGC
hsa-miR-26bSZUUCAAGUAAUUCAGGAUAGGUU
miR-328537543m8hsa-miR-328brainCUGGCCCUCUCUGCCCUUCCGU
miR-49129351Ahsa-miR-491brainAGUGGGGAACCCUUCCAUGAGGA
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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