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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets

Gene Ranking Integration

Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets Datasets Gene Ranking

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Gene Page: IKZF2

Summary

GeneID

22807

Symbol

IKZF2

Synonyms

HELIOS|MGC34330|ZNF1A2|ZNFN1A2

Description

IKAROS family zinc finger 2 (Helios)

Locus tag

Gene type

protein-coding

Map location

2q34

Gene in Data Sources

Gene set name

Method of gene set

Evidence

Info

GSMA_IIE

genome scan meta-analysis (European-ancestry samples)

Psr: 0.01016

GSMA_IIA

genome scan meta-analysis (All samples)

Psr: 0.00916

General Gene Expression (microarray) ?

Gene Expression in Brain Regions (new)

Top co-expressed genes in Brain Regions (new)

Gene

Pearson's Correlation

Spearman's Correlation

Top 10 positively co-expressed genes

ERMP1

0.95

0.89

LAMP2

0.93

0.91

SYNJ2

0.93

0.80

SLC12A2

0.93

0.85

GLDN

0.92

0.79

PXK

0.91

0.80

ENPP4

0.91

0.90

NIPAL3

0.91

0.87

PRUNE2

0.91

0.89

ABCA8

0.90

0.78

Top 10 negatively co-expressed genes

BCL7C

-0.53

-0.63

C9orf46

-0.50

-0.59

RPL36

-0.50

-0.64

EXOSC8

-0.49

-0.56

RPL35

-0.49

-0.62

AC006276.2

-0.49

-0.53

RPL12

-0.48

-0.57

NR2C2AP

-0.48

-0.45

ALKBH2

-0.47

RPS23

-0.47

-0.59

Gene Ontology

Molecular function

GO term

Evidence

Neuro keywords

PubMed ID

GO:0003674

molecular_function

GO:0003676

nucleic acid binding

IEA

GO:0003677

DNA binding

IEA

GO:0008270

zinc ion binding

IEA

GO:0046872

metal ion binding

IEA

Biological process

GO term

Evidence

Neuro keywords

PubMed ID

GO:0006355

regulation of transcription, DNA-dependent

IEA

GO:0006350

transcription

IEA

GO:0008150

biological_process

Cellular component

GO term

Evidence

Neuro keywords

PubMed ID

GO:0005622

intracellular

IEA

GO:0005634

nucleus

NAS

Protein-protein Interactions

Shown by network

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
CHD4	DKFZp686E06161 \| Mi-2b \| Mi2-BETA	chromodomain helicase DNA binding protein 4	Affinity Capture-Western	BioGRID	12015313
HDAC2	RPD3 \| YAF1	histone deacetylase 2	Affinity Capture-Western	BioGRID	12015313
HDAC4	HA6116 \| HD4 \| HDAC-A \| HDACA \| KIAA0288	histone deacetylase 4	Reconstituted Complex	BioGRID	12943985
HDAC5	FLJ90614 \| HD5 \| NY-CO-9	histone deacetylase 5	Affinity Capture-Western	BioGRID	12015313
IKZF1	Hs.54452 \| IK1 \| IKAROS \| LYF1 \| PRO0758 \| ZNFN1A1 \| hIk-1	IKAROS family zinc finger 1 (Ikaros)	-	HPRD,BioGRID	9560339
IKZF2	HELIOS \| MGC34330 \| ZNF1A2 \| ZNFN1A2	IKAROS family zinc finger 2 (Helios)	-	HPRD,BioGRID	9560339
IKZF3	AIO \| AIOLOS \| ZNFN1A3	IKAROS family zinc finger 3 (Aiolos)	Affinity Capture-Western	BioGRID	9560339
IKZF4	EOS \| KIAA1782 \| ZNFN1A4	IKAROS family zinc finger 4 (Eos)	-	HPRD	10978333
IKZF5	DKFZp781B0249 \| FLJ22973 \| PEGASUS \| ZNFN1A5	IKAROS family zinc finger 5 (Pegasus)	-	HPRD	10978333
SIN3A	DKFZp434K2235 \| FLJ90319 \| KIAA0700	SIN3 homolog A, transcription regulator (yeast)	Affinity Capture-Western	BioGRID	12015313
SIN3B	KIAA0700	SIN3 homolog B, transcription regulator (yeast)	Affinity Capture-Western	BioGRID	12015313

miRNA Targets ?

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
let-7/98	7191	7197	1A	hsa-let-7a^brain	UGAGGUAGUAGGUUGUAUAGUU
				hsa-let-7b^brain	UGAGGUAGUAGGUUGUGUGGUU
				hsa-let-7c^brain	UGAGGUAGUAGGUUGUAUGGUU
				hsa-let-7d^brain	AGAGGUAGUAGGUUGCAUAGU
				hsa-let-7e^brain	UGAGGUAGGAGGUUGUAUAGU
				hsa-let-7f^brain	UGAGGUAGUAGAUUGUAUAGUU
				hsa-miR-98^brain	UGAGGUAGUAAGUUGUAUUGUU
				hsa-let-7g^SZ	UGAGGUAGUAGUUUGUACAGU
				hsa-let-7i^brain	UGAGGUAGUAGUUUGUGCUGU
miR-1/206	8	14	1A	hsa-miR-1	UGGAAUGUAAAGAAGUAUGUA
				hsa-miR-206^SZ	UGGAAUGUAAGGAAGUGUGUGG
				hsa-miR-613	AGGAAUGUUCCUUCUUUGCC
miR-101	7503	7509	m8	hsa-miR-101	UACAGUACUGUGAUAACUGAAG
miR-124/506	4158	4164	m8	hsa-miR-506	UAAGGCACCCUUCUGAGUAGA
miR-124/506	4158	4164	m8	hsa-miR-124^brain	UAAGGCACGCGGUGAAUGCC
miR-128	5499	5505	1A	hsa-miR-128a	UCACAGUGAACCGGUCUCUUUU
miR-128	5499	5505	1A	hsa-miR-128b	UCACAGUGAACCGGUCUCUUUC
miR-141/200a	962	969	1A,m8	hsa-miR-141	UAACACUGUCUGGUAAAGAUGG
miR-141/200a	962	969	1A,m8	hsa-miR-200a	UAACACUGUCUGGUAACGAUGU
miR-142-5p	944	950	m8	hsa-miR-142-5p	CAUAAAGUAGAAAGCACUAC
miR-145	7524	7530	1A	hsa-miR-145	GUCCAGUUUUCCCAGGAAUCCCUU
miR-17-5p/20/93.mr/106/519.d	943	949	1A	hsa-miR-17-5p	CAAAGUGCUUACAGUGCAGGUAGU
				hsa-miR-20a^brain	UAAAGUGCUUAUAGUGCAGGUAG
				hsa-miR-106a	AAAAGUGCUUACAGUGCAGGUAGC
				hsa-miR-106b^SZ	UAAAGUGCUGACAGUGCAGAU
				hsa-miR-20b^SZ	CAAAGUGCUCAUAGUGCAGGUAG
				hsa-miR-519d	CAAAGUGCCUCCCUUUAGAGUGU
miR-186	6914	6920	1A	hsa-miR-186	CAAAGAAUUCUCCUUUUGGGCUU
miR-200bc/429	4539	4545	m8	hsa-miR-200b	UAAUACUGCCUGGUAAUGAUGAC
				hsa-miR-200c	UAAUACUGCCGGGUAAUGAUGG
				hsa-miR-429	UAAUACUGUCUGGUAAAACCGU
miR-203.1	6831	6837	m8	hsa-miR-203	UGAAAUGUUUAGGACCACUAG
miR-208	6050	6056	1A	hsa-miR-208	AUAAGACGAGCAAAAAGCUUGU
miR-208	6050	6056	1A	hsa-miR-208	AUAAGACGAGCAAAAAGCUUGU
miR-219	2378	2384	1A	hsa-miR-219^brain	UGAUUGUCCAAACGCAAUUCU
miR-25/32/92/363/367	6242	6249	1A,m8	hsa-miR-25^brain	CAUUGCACUUGUCUCGGUCUGA
				hsa-miR-32	UAUUGCACAUUACUAAGUUGC
				hsa-miR-92	UAUUGCACUUGUCCCGGCCUG
				hsa-miR-367	AAUUGCACUUUAGCAAUGGUGA
				hsa-miR-92b^SZ	UAUUGCACUCGUCCCGGCCUC
miR-27	5499	5505	m8	hsa-miR-27a^brain	UUCACAGUGGCUAAGUUCCGC
miR-27	5499	5505	m8	hsa-miR-27b^brain	UUCACAGUGGCUAAGUUCUGC
miR-30-5p	553	559	m8	hsa-miR-30a-5p	UGUAAACAUCCUCGACUGGAAG
				hsa-miR-30c^brain	UGUAAACAUCCUACACUCUCAGC
				hsa-miR-30d^SZ	UGUAAACAUCCCCGACUGGAAG
				hsa-miR-30b^SZ	UGUAAACAUCCUACACUCAGCU
				hsa-miR-30e-5p	UGUAAACAUCCUUGACUGGA
miR-329	7434	7440	1A	hsa-miR-329^brain	AACACACCUGGUUAACCUCUUU
miR-34b	162	168	1A	hsa-miR-34b	UAGGCAGUGUCAUUAGCUGAUUG
miR-369-3p	7489	7495	1A	hsa-miR-369-3p	AAUAAUACAUGGUUGAUCUUU
miR-374	7489	7496	1A,m8	hsa-miR-374	UUAUAAUACAACCUGAUAAGUG
miR-376	25	31	1A	hsa-miR-376a	AUCAUAGAGGAAAAUCCACGU
miR-376	25	31	1A	hsa-miR-376b	AUCAUAGAGGAAAAUCCAUGUU
miR-377	7242	7248	m8	hsa-miR-377	AUCACACAAAGGCAACUUUUGU
miR-377	7242	7248	m8	hsa-miR-377	AUCACACAAAGGCAACUUUUGU
miR-378	7546	7552	1A	hsa-miR-378	CUCCUGACUCCAGGUCCUGUGU
miR-381	7402	7408	1A	hsa-miR-381	UAUACAAGGGCAAGCUCUCUGU
				hsa-miR-381	UAUACAAGGGCAAGCUCUCUGU
				hsa-miR-381	UAUACAAGGGCAAGCUCUCUGU
miR-448	7406	7412	m8	hsa-miR-448	UUGCAUAUGUAGGAUGUCCCAU
miR-493-5p	7437	7443	1A	hsa-miR-493-5p	UUGUACAUGGUAGGCUUUCAUU
miR-499	6260	6267	1A,m8	hsa-miR-499	UUAAGACUUGCAGUGAUGUUUAA
miR-499	6260	6267	1A,m8	hsa-miR-499	UUAAGACUUGCAGUGAUGUUUAA
miR-544	978	984	1A	hsa-miR-544	AUUCUGCAUUUUUAGCAAGU
miR-9	6926	6932	m8	hsa-miR-9^SZ	UCUUUGGUUAUCUAGCUGUAUGA
miR-93.hd/291-3p/294/295/302/372/373/520	59	65	1A	hsa-miR-93^brain	AAAGUGCUGUUCGUGCAGGUAG
				hsa-miR-302a	UAAGUGCUUCCAUGUUUUGGUGA
				hsa-miR-302b	UAAGUGCUUCCAUGUUUUAGUAG
				hsa-miR-302c	UAAGUGCUUCCAUGUUUCAGUGG
				hsa-miR-302d	UAAGUGCUUCCAUGUUUGAGUGU
				hsa-miR-372	AAAGUGCUGCGACAUUUGAGCGU
				hsa-miR-373	GAAGUGCUUCGAUUUUGGGGUGU
				hsa-miR-520e	AAAGUGCUUCCUUUUUGAGGG
				hsa-miR-520a	AAAGUGCUUCCCUUUGGACUGU
				hsa-miR-520b	AAAGUGCUUCCUUUUAGAGGG
				hsa-miR-520c	AAAGUGCUUCCUUUUAGAGGGUU
				hsa-miR-520d	AAAGUGCUUCUCUUUGGUGGGUU
				hsa-miR-93^brain	AAAGUGCUGUUCGUGCAGGUAG
				hsa-miR-302a	UAAGUGCUUCCAUGUUUUGGUGA
				hsa-miR-302b	UAAGUGCUUCCAUGUUUUAGUAG
				hsa-miR-302c	UAAGUGCUUCCAUGUUUCAGUGG
				hsa-miR-302d	UAAGUGCUUCCAUGUUUGAGUGU
				hsa-miR-372	AAAGUGCUGCGACAUUUGAGCGU
				hsa-miR-373	GAAGUGCUUCGAUUUUGGGGUGU
				hsa-miR-520e	AAAGUGCUUCCUUUUUGAGGG
				hsa-miR-520a	AAAGUGCUUCCCUUUGGACUGU
				hsa-miR-520b	AAAGUGCUUCCUUUUAGAGGG
				hsa-miR-520c	AAAGUGCUUCCUUUUAGAGGGUU
				hsa-miR-520d	AAAGUGCUUCUCUUUGGUGGGUU

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.