Gene Page: MYO16

Summary ?
GeneID23026
SymbolMYO16
SynonymsMYAP3|MYR8|Myo16b|NYAP3|PPP1R107
Descriptionmyosin XVI
ReferenceMIM:615479|HGNC:HGNC:29822|Ensembl:ENSG00000041515|HPRD:14795|Vega:OTTHUMG00000017333
Gene typeprotein-coding
Map location13q33.3
Pascal p-value0.026
Sherlock p-value0.355
DMG1 (# studies)
SupportCompositeSet
Darnell FMRP targets
Potential synaptic genes

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:GWAScatGenome-wide Association StudiesThis data set includes 560 SNPs associated with schizophrenia. A total of 486 genes were mapped to these SNPs within 50kb.
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Wockner_2014Genome-wide DNA methylation analysisThis dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 2
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophreniasClick to show details
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg2689952613109794149MYO168.36E-50.4590.026DMG:Wockner_2014
cg2442580713109741176MYO163.71E-40.6990.043DMG:Wockner_2014


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
KIAA12190.950.96
HECTD10.950.96
FAM160B10.940.96
RNMT0.940.95
ZBTB380.930.94
USP9X0.930.95
GNAQ0.930.96
BAG50.930.95
CPEB40.930.95
ZYG11B0.930.96
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
FXYD1-0.71-0.76
MT-CO2-0.69-0.76
HIGD1B-0.68-0.76
AF347015.31-0.68-0.74
HSD17B14-0.66-0.71
TLCD1-0.66-0.71
ENHO-0.66-0.76
AC021016.1-0.65-0.70
IFI27-0.65-0.72
AF347015.33-0.65-0.69

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0003774motor activityIEA-
GO:0005524ATP bindingIEA-
GO:0051015actin filament bindingISS11588169 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0021549cerebellum developmentISSBrain (GO term level: 10)11588169 
GO:0008285negative regulation of cell proliferationISS17029291 
GO:0045749negative regulation of S phase of mitotic cell cycleISS17029291 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005654nucleoplasmIDA17029291 
GO:0005737cytoplasmISS11588169 
GO:0005886plasma membraneISS11588169 |17029291 
GO:0048471perinuclear region of cytoplasmIDA17029291 
GO:0016459myosin complexIEA-

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
YAGI AML FAB MARKERS 191131All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 4 307185All SZGR 2.0 genes in this pathway
KONDO EZH2 TARGETS 245148All SZGR 2.0 genes in this pathway
MASSARWEH TAMOXIFEN RESISTANCE DN 258160All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER WITH H3K9ME3 UP 14175All SZGR 2.0 genes in this pathway
MEISSNER BRAIN HCP WITH H3K4ME3 AND H3K27ME3 1069729All SZGR 2.0 genes in this pathway
MIKKELSEN MCV6 HCP WITH H3K27ME3 435318All SZGR 2.0 genes in this pathway