Gene Page: TRIM35

Summary ?
GeneID23087
SymbolTRIM35
SynonymsHLS5|MAIR
Descriptiontripartite motif containing 35
ReferenceHGNC:HGNC:16285|Ensembl:ENSG00000104228|HPRD:15553|Vega:OTTHUMG00000102047
Gene typeprotein-coding
Map location8p21.2
Pascal p-value0.01
eGeneCerebellum
Cortex
Meta

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
GSMA_IGenome scan meta-analysisPsr: 0.031 
GSMA_IIAGenome scan meta-analysis (All samples)Psr: 0.03086 
GSMA_IIEGenome scan meta-analysis (European-ancestry samples)Psr: 0.00057 

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
SRGAP20.960.98
ZNF4450.960.97
MED10.960.98
KLF70.960.97
ADNP0.960.98
ZNF3980.960.97
KDM4A0.950.97
CHD80.950.98
NSD10.950.98
FAM123B0.950.96
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
AF347015.31-0.74-0.92
MT-CO2-0.72-0.92
C5orf53-0.72-0.77
AF347015.27-0.72-0.89
S100B-0.72-0.85
AIFM3-0.71-0.77
FXYD1-0.71-0.89
HLA-F-0.71-0.76
AF347015.33-0.71-0.87
TSC22D4-0.71-0.80

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005515protein bindingIEA-
GO:0008270zinc ion bindingIEA-
GO:0046872metal ion bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006915apoptosisIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005622intracellularIEA-
GO:0005634nucleusIEA-
GO:0005737cytoplasmIEA-

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
DING LUNG CANCER EXPRESSION BY COPY NUMBER 10062All SZGR 2.0 genes in this pathway
RIGGI EWING SARCOMA PROGENITOR UP 430288All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA CHEMOTAXIS DN 457302All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA HAPTOTAXIS DN 668419All SZGR 2.0 genes in this pathway
CHIANG LIVER CANCER SUBCLASS POLYSOMY7 UP 7950All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN 19721213All SZGR 2.0 genes in this pathway
KASLER HDAC7 TARGETS 1 UP 194133All SZGR 2.0 genes in this pathway