Gene Page: FLNA

Summary
GeneID  2316
Symbol  FLNA
Synonyms  ABP-280|ABPX|DKFZp434P031|FLN|FLN1|FMD|MNS|NHBP|OPD|OPD1|OPD2
Description  filamin A, alpha (actin binding protein 280)
See related  HGNC:3754|MIM:300017|Ensembl:ENSG00000196924|HPRD:02060|
Locus tag  XX-FW83128A1.1
Gene type  protein-coding
Map location  Xq28
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 7.702 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
VPS410.900.89
ARMCX30.900.88
SENP20.900.89
AGGF10.890.90
SBNO10.890.92
KIF3A0.880.91
RANBP90.880.88
RMND5A0.880.88
PPM1B0.870.87
LONP20.870.87
Top 10 negatively co-expressed genes
AF347015.21-0.65-0.56
ENHO-0.63-0.69
C1orf54-0.61-0.61
C1orf61-0.61-0.68
METRN-0.60-0.59
HIGD1B-0.60-0.56
VAMP5-0.60-0.56
FXYD1-0.59-0.54
IFI27-0.58-0.55
RHOC-0.58-0.64
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003779actin bindingIEA-
GO:0004871signal transducer activityIMP12761501 
GO:0005080protein kinase C bindingIEA-
GO:0008134transcription factor bindingIPI15684392 
GO:0051015actin filament bindingTAS9883725 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007399nervous system developmentTASneurite (GO term level: 5)9883725 
GO:0030036actin cytoskeleton organizationTAS2391361 
GO:0042993positive regulation of transcription factor import into nucleusIMP15684392 
GO:0043433negative regulation of transcription factor activityIDA15684392 
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB cascadeIMP12761501 
GO:0045022early endosome to late endosome transportIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005802trans-Golgi networkIEA-
GO:0005856cytoskeletonIDA18029348 
GO:0005634nucleusIDA15684392 
GO:0005737cytoplasmIDA15684392 |18029348 
GO:0015629actin cytoskeletonTAS2391361 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ARAIS | DHTR | HUMARA | KD | NR3C4 | SBMA | SMAX1 | TFMandrogen receptor-HPRD,BioGRID12682292 
BRCA1BRCAI | BRCC1 | IRIS | PSCP | RNF53breast cancer 1, early onset-HPRD11602572 
BRCA2BRCC2 | FACD | FAD | FAD1 | FANCB | FANCD | FANCD1breast cancer 2, early onset-HPRD,BioGRID11602572 
BRCA2 interacts with hsFLNa.BIND11602572 
CASRCAR | FHH | FIH | GPRC2A | HHC | HHC1 | MGC138441 | NSHPT | PCAR1calcium-sensing receptor-HPRD,BioGRID11390379 |11390380 
CAV1CAV | MSTP085 | VIP21caveolin 1, caveolae protein, 22kDa-HPRD10637311 
CDC42CDC42Hs | G25Kcell division cycle 42 (GTP binding protein, 25kDa)-HPRD10051605 
CMIPKIAA1694c-Maf-inducing protein-HPRD,BioGRID15128042 
DCNCSCD | DSPG2 | PG40 | PGII | PGS2 | SLRR1Bdecorin-HPRD,BioGRID12106908 
DRD2D2DR | D2Rdopamine receptor D2Affinity Capture-WesternBioGRID12181426 
Dopamine receptor D2 interacts with filamin A. This interaction was modeled on a demonstrated interaction between human FLN-A and D2 from unspecified source.BIND11320256 
-HPRD11911837 
DRD3D3DR | ETM1 | FET1 | MGC149204 | MGC149205dopamine receptor D3Dopamine receptor D3 interacts with filamin A. This interaction was modeled on a demonstrated interaction between human FLN-A and D3 from unspecified source.BIND11320256 
-HPRD,BioGRID11911837 
F3CD142 | TF | TFAcoagulation factor III (thromboplastin, tissue factor)-HPRD,BioGRID9490735 
FBLIM1CAL | DKFZp434G171 | FBLP-1 | FBLP1 | RP11-169K16.5filamin binding LIM protein 1-HPRD,BioGRID12679033 
FLNBABP-278 | AOI | DKFZp686A1668 | DKFZp686O033 | FH1 | FLN1L | LRS1 | SCT | TABP | TAPfilamin B, beta (actin binding protein 278)-HPRD,BioGRID12393796 
FURINFUR | PACE | PCSK3 | SPC1furin (paired basic amino acid cleaving enzyme)-HPRD9412467 
GP1BABSS | CD42B | CD42b-alpha | GP1B | MGC34595glycoprotein Ib (platelet), alpha polypeptide-HPRD,BioGRID11700320 
GRIK1EAA3 | EEA3 | GLR5 | GLUR5glutamate receptor, ionotropic, kainate 1-HPRD11943148 
GRIK3EAA5 | GLR7 | GLUR7 | GluR7aglutamate receptor, ionotropic, kainate 3-HPRD11943148 
GRM8FLJ41058 | GLUR8 | GPRC1H | MGC126724 | MGLUR8 | mGlu8glutamate receptor, metabotropic 8-HPRD11943148 
ITGB1CD29 | FNRB | GPIIA | MDF2 | MSK12 | VLA-BETA | VLABintegrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)-HPRD,BioGRID9722563 |11807098 
ITGB3CD61 | GP3A | GPIIIaintegrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)Two-hybridBioGRID11807098 
ITGB6-integrin, beta 6Two-hybridBioGRID11807098 
ITGB7-integrin, beta 7-HPRD,BioGRID11781567 
MAP2K4JNKK | JNKK1 | MAPKK4 | MEK4 | MKK4 | PRKMK4 | SEK1 | SERK1mitogen-activated protein kinase kinase 4-HPRD9006895 
MAP3K7TAK1 | TGF1amitogen-activated protein kinase kinase kinase 7-HPRD14743216 
MAP3K7IP2FLJ21885 | KIAA0733 | TAB2mitogen-activated protein kinase kinase kinase 7 interacting protein 2-HPRD14743216 
MAPK14CSBP1 | CSBP2 | CSPB1 | EXIP | Mxi2 | PRKM14 | PRKM15 | RK | SAPK2A | p38 | p38ALPHAmitogen-activated protein kinase 14-HPRD11390380 
MYOTLGMD1 | LGMD1A | TTIDmyotilin-HPRD,BioGRID11038172 
NPHP1FLJ97602 | JBTS4 | NPH1 | SLSN1nephronophthisis 1 (juvenile)-HPRD,BioGRID12006559 
RAC1MGC111543 | MIG5 | TC-25 | p21-Rac1ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)-HPRD10051605 
RALAMGC48949 | RALv-ral simian leukemia viral oncogene homolog A (ras related)-HPRD,BioGRID10051605 
RHOAARH12 | ARHA | RHO12 | RHOH12ras homolog gene family, member A-HPRD10051605 
SELECD62E | ELAM | ELAM1 | ESEL | LECAM2selectin E-HPRD8609175 
SH2B3CELIAC13 | LNKSH2B adaptor protein 3-HPRD,BioGRID11163396 
SIGLEC10MGC126774 | PRO940 | SIGLEC-10 | SLG2sialic acid binding Ig-like lectin 10-HPRD,BioGRID12055638 
TNIP2ABIN-2 | ABIN2 | FLIP1 | KLIP | MGC4289TNFAIP3 interacting protein 2-HPRD12753905 
TRAF2MGC:45012 | TRAP | TRAP3TNF receptor-associated factor 2-HPRD,BioGRID10617615 
TRIOFLJ42780 | tgattriple functional domain (PTPRF interacting)-HPRD,BioGRID11146652 
VHLHRCA1 | RCA1 | VHL1von Hippel-Lindau tumor suppressorThe von Hippel-Lindau tumor suppressor protein (pVHL) interacts with FLNA .BIND12169691 
-HPRD,BioGRID8674032 |12169691 
 
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-146275281m8hsa-miR-146aUGAGAACUGAAUUCCAUGGGUU
hsa-miR-146bbrainUGAGAACUGAAUUCCAUAGGCU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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