Gene Page: ATMIN
Summary ?
| GeneID | 23300 |
| Symbol | ATMIN |
| Synonyms | ASCIZ|ZNF822 |
| Description | ATM interactor |
| Reference | MIM:614693|HGNC:HGNC:29034|Ensembl:ENSG00000166454|HPRD:17188|Vega:OTTHUMG00000176469 |
| Gene type | protein-coding |
| Map location | 16q23.2 |
| Pascal p-value | 0.508 |
| Sherlock p-value | 0.625 |
| Fetal beta | -0.093 |
| DMG | 1 (# studies) |
| Support | CompositeSet Darnell FMRP targets |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| DMG:Jaffe_2016 | Genome-wide DNA methylation analysis | This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. | 1 |
Section I. Genetics and epigenetics annotation
Differentially methylated gene
| Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
|---|---|---|---|---|---|---|---|
| cg05621273 | 16 | 81070150 | ATMIN | 1.02E-9 | -0.015 | 1.18E-6 | DMG:Jaffe_2016 |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| NNMT | 0.83 | 0.85 |
| C6orf1 | 0.79 | 0.68 |
| TMEM160 | 0.76 | 0.61 |
| PKIG | 0.74 | 0.65 |
| PRSS3 | 0.74 | 0.80 |
| NDUFA7 | 0.73 | 0.67 |
| PRRX2 | 0.73 | 0.77 |
| CCK | 0.73 | 0.77 |
| NPPA | 0.73 | 0.75 |
| CAPN12 | 0.72 | 0.65 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| MAP4K4 | -0.49 | -0.69 |
| AC005035.1 | -0.48 | -0.69 |
| ZNF326 | -0.48 | -0.69 |
| C17orf85 | -0.47 | -0.70 |
| THOC2 | -0.47 | -0.71 |
| YTHDC1 | -0.47 | -0.65 |
| KCTD3 | -0.47 | -0.65 |
| IWS1 | -0.47 | -0.67 |
| C16orf88 | -0.46 | -0.68 |
| NCL | -0.45 | -0.67 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| ONKEN UVEAL MELANOMA UP | 783 | 507 | All SZGR 2.0 genes in this pathway |
| SENESE HDAC3 TARGETS DN | 536 | 332 | All SZGR 2.0 genes in this pathway |
| PROVENZANI METASTASIS UP | 194 | 112 | All SZGR 2.0 genes in this pathway |
| NUYTTEN EZH2 TARGETS DN | 1024 | 594 | All SZGR 2.0 genes in this pathway |
| SHEN SMARCA2 TARGETS UP | 424 | 268 | All SZGR 2.0 genes in this pathway |
| MATSUDA NATURAL KILLER DIFFERENTIATION | 475 | 313 | All SZGR 2.0 genes in this pathway |
| SANSOM APC MYC TARGETS | 217 | 138 | All SZGR 2.0 genes in this pathway |
| SANSOM APC TARGETS REQUIRE MYC | 210 | 123 | All SZGR 2.0 genes in this pathway |
| HAN SATB1 TARGETS UP | 395 | 249 | All SZGR 2.0 genes in this pathway |
| GOBERT OLIGODENDROCYTE DIFFERENTIATION DN | 1080 | 713 | All SZGR 2.0 genes in this pathway |