Gene Page: ICOSLG

Summary
GeneID  23308
Symbol  ICOSLG
Synonyms  B7-H2|B7H2|B7RP-1|B7RP1|CD275|GL50|ICOS-L|ICOSL|KIAA0653|LICOS
Description  inducible T-cell co-stimulator ligand
See related  HGNC:17087|MIM:605717|Ensembl:ENSG00000160223|HPRD:05757|
Locus tag  -
Gene type  protein-coding
Map location  21q22.3
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
FIBIN0.800.79
SUCLG20.780.78
EDNRB0.760.82
PSAT10.750.77
GLUD10.750.76
RAB310.740.76
SDC20.740.78
ANXA50.740.78
BCAN0.740.75
KCNJ160.740.77
Top 10 negatively co-expressed genes
MPPED1-0.44-0.44
NEUROD2-0.42-0.46
SLA-0.42-0.34
IER5L-0.41-0.42
SSBP3-0.41-0.44
TMEM108-0.41-0.31
ATXN7L1-0.41-0.37
DACT1-0.41-0.34
TIAM2-0.41-0.42
NELL2-0.40-0.39
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005102receptor bindingTASNeurotransmitter (GO term level: 4)11429535 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006972hyperosmotic responseNAS12145647 
GO:0007165signal transductionNAS12145647 
GO:0006955immune responseIEA-
GO:0006952defense responseNAS11983910 
GO:0042113B cell activationIEA-
GO:0042110T cell activationNAS11983910 
GO:0042104positive regulation of activated T cell proliferationTAS11429535 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0016020membraneIEA-
GO:0016021integral to membraneNAS12145647 
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ICOSAILIM | CD278 | MGC39850inducible T-cell co-stimulator-HPRD,BioGRID10657606 |11023515 
|11956294 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_CELL_ADHESION_MOLECULES_CAMS 13493All SZGR genes in this pathway
KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION 4836All SZGR genes in this pathway
BIOCARTA_CTLA4_PATHWAY 2118All SZGR genes in this pathway
REACTOME_COSTIMULATION_BY_THE_CD28_FAMILY 6348All SZGR genes in this pathway
REACTOME_IMMUNE_SYSTEM 933616All SZGR genes in this pathway
REACTOME_ADAPTIVE_IMMUNE_SYSTEM 539350All SZGR genes in this pathway
ZHOU_INFLAMMATORY_RESPONSE_LIVE_UP 485293All SZGR genes in this pathway
MULLIGHAN_MLL_SIGNATURE_2_DN 281186All SZGR genes in this pathway
ZHOU_INFLAMMATORY_RESPONSE_FIMA_UP 544308All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN 17811082All SZGR genes in this pathway
SHETH_LIVER_CANCER_VS_TXNIP_LOSS_PAM6 4632All SZGR genes in this pathway
PUJANA_ATM_PCC_NETWORK 1442892All SZGR genes in this pathway
KOYAMA_SEMA3B_TARGETS_DN 411249All SZGR genes in this pathway
SHEN_SMARCA2_TARGETS_DN 357212All SZGR genes in this pathway
SANA_TNF_SIGNALING_UP 8356All SZGR genes in this pathway
MATSUDA_NATURAL_KILLER_DIFFERENTIATION 475313All SZGR genes in this pathway
BASSO_CD40_SIGNALING_UP 10176All SZGR genes in this pathway
FOSTER_TOLERANT_MACROPHAGE_DN 409268All SZGR genes in this pathway
QI_PLASMACYTOMA_UP 259185All SZGR genes in this pathway
SEKI_INFLAMMATORY_RESPONSE_LPS_UP 7756All SZGR genes in this pathway
CHEN_METABOLIC_SYNDROM_NETWORK 1210725All SZGR genes in this pathway
MEISSNER_BRAIN_HCP_WITH_H3K4ME3_AND_H3K27ME3 1069729All SZGR genes in this pathway
PURBEY_TARGETS_OF_CTBP1_AND_SATB1_DN 180116All SZGR genes in this pathway


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