Gene Page: NCSTN

Summary
GeneID  23385
Symbol  NCSTN
Synonyms  APH2|KIAA0253
Description  nicastrin
See related  HGNC:17091|MIM:605254|Ensembl:ENSG00000162736|HPRD:05584|
Locus tag  RP11-517F10.1
Gene type  protein-coding
Map location  1q22-q23
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_Igenome scan meta-analysisPsr: 0.0235 
GSMA_IIAgenome scan meta-analysis (All samples)Psr: 0.00814 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005515protein bindingIPI12297508 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0042987amyloid precursor protein catabolic processTAS15274632 
GO:0006508proteolysisNAS10993067 
GO:0006509membrane protein ectodomain proteolysisIDA15274632 
GO:0007220Notch receptor processingTAS15274632 
GO:0016485protein processingIDA15274632 
GO:0016485protein processingIEA-
GO:0043085positive regulation of catalytic activityIDA15274632 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005794Golgi apparatusIDA15274632 
GO:0005783endoplasmic reticulumIDA15274632 
GO:0016020membraneIEA-
GO:0016021integral to membraneIEA-
GO:0005887integral to plasma membraneIDA15274632 
GO:0042470melanosomeIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ABL1ABL | JTK7 | bcr/abl | c-ABL | p150 | v-ablc-abl oncogene 1, receptor tyrosine kinase-HPRD12021275 
APH1A6530402N02Rik | APH-1A | CGI-78anterior pharynx defective 1 homolog A (C. elegans)-HPRD,BioGRID12297508 
APH1BAPH-1B | DKFZp564D0372 | PRO1328 | PSFL | TAAV688anterior pharynx defective 1 homolog B (C. elegans)-HPRD12297508 
APPAAA | ABETA | ABPP | AD1 | APPI | CTFgamma | CVAP | PN2amyloid beta (A4) precursor protein-HPRD,BioGRID10993067 
BACE1ASP2 | BACE | FLJ90568 | HSPC104 | KIAA1149beta-site APP-cleaving enzyme 1Nicastrin interacts with BACE1.BIND12054507 
-HPRD,BioGRID12054507 
PSEN1AD3 | FAD | PS1 | S182presenilin 1PS1 interacts with Nicastrin.BIND10993067 
Affinity Capture-WesternBioGRID10993067 |12297508 
|12471034 |14572442 
|15257293 
PSEN2AD3L | AD4 | PS2 | STM2presenilin 2 (Alzheimer disease 4)-HPRD,BioGRID10993067 
PSENENMDS033 | MSTP064 | PEN-2 | PEN2presenilin enhancer 2 homolog (C. elegans)-HPRD,BioGRID12198112 
PEN-2 interacts with NCT.BIND15322109 
 


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