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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets

Gene Ranking Integration

Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets Datasets Gene Ranking

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Gene Page: FREQ

Summary

GeneID

23413

Symbol

FREQ

Synonyms

DKFZp761L1223|FLUP|NCS-1|NCS1

Description

frequenin homolog (Drosophila)

Locus tag

Gene type

protein-coding

Map location

9q34

Gene in Data Sources

Gene set name

Method of gene set

Evidence

Info

Literature

High-throughput literature-search

Co-occurance with Schizophrenia keywords: [schizophrenias, schizophrenic, schizophrenia]

Click to show detail

GO_Annotation

Mapping neuro-related keywords to Gene Ontology annotations

Hits with neuro-related keywords: 2

Network

Shortest path distance of core genes in the Human protein-protein interaction network

Contribution to shortest path in PPI network: 0.0234

General Gene Expression (microarray) ?

Gene Expression in Brain Regions (new)

Top co-expressed genes in Brain Regions (new)

Gene

Pearson's Correlation

Spearman's Correlation

Top 10 positively co-expressed genes

ZNF134

0.96

NFX1

0.96

ZNF623

0.96

0.97

CTR9

0.95

0.96

TLK2

0.95

0.96

C1orf107

0.95

0.96

SART3

0.95

THRAP3

0.95

0.96

CHD8

0.95

0.96

ZNF304

0.95

0.96

Top 10 negatively co-expressed genes

AF347015.31

-0.82

-0.90

MT-CO2

-0.81

-0.90

FXYD1

-0.80

-0.89

IFI27

-0.80

-0.89

AF347015.27

-0.79

-0.87

AF347015.33

-0.79

-0.87

HIGD1B

-0.78

-0.89

AF347015.8

-0.77

-0.88

MT-CYB

-0.77

-0.86

HLA-F

-0.76

-0.79

Gene Ontology

Molecular function

GO term

Evidence

Neuro keywords

PubMed ID

GO:0005509

calcium ion binding

IEA

GO:0005509

calcium ion binding

TAS

11092894

Cellular component

GO term

Evidence

Neuro keywords

PubMed ID

GO:0030425

dendrite

IEA

neuron, axon, dendrite (GO term level: 6)

GO:0030424

axon

IEA

neuron, axon, Neurotransmitter (GO term level: 6)

GO:0005794

Golgi apparatus

IEA

GO:0016020

membrane

IEA

Protein-protein Interactions

Shown by network

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
ADRBK1	BARK1 \| BETA-ARK1 \| FLJ16718 \| GRK2	adrenergic, beta, receptor kinase 1	-	HPRD	12351722
DRD2	D2DR \| D2R	dopamine receptor D2	-	HPRD,BioGRID	12351722
DRD2	D2DR \| D2R	dopamine receptor D2	The D2 dopamine receptor interacts with NCS-1.	BIND	12351722
DRD3	D3DR \| ETM1 \| FET1 \| MGC149204 \| MGC149205	dopamine receptor D3	Affinity Capture-Western	BioGRID	12351722
DRD3	D3DR \| ETM1 \| FET1 \| MGC149204 \| MGC149205	dopamine receptor D3	The D3 dopamine receptor interacts with NCS-1.	BIND	12351722
DRD5	DBDR \| DRD1B \| DRD1L2 \| MGC10601	dopamine receptor D5	NCS-1 interacts with the D5 dopamine receptor.	BIND	12351722
DTX2	KIAA1528 \| MGC71098 \| RNF58	deltex homolog 2 (Drosophila)	Two-hybrid	BioGRID	16189514
IL1RAPL1	IL1R8 \| IL1RAPL \| MRX21 \| MRX34 \| OPHN4 \| TIGIRR-2	interleukin 1 receptor accessory protein-like 1	Affinity Capture-Western Reconstituted Complex Two-hybrid	BioGRID	12783849
KCND2	KIAA1044 \| KV4.2 \| MGC119702 \| MGC119703 \| RK5	potassium voltage-gated channel, Shal-related subfamily, member 2	Affinity Capture-Western	BioGRID	11606724
PI4KB	PI4K-BETA \| PI4KIIIbeta \| PI4Kbeta \| PIK4CB \| pi4K92	phosphatidylinositol 4-kinase, catalytic, beta	Affinity Capture-Western Reconstituted Complex	BioGRID	11526106 \|14607934
PI4KB	PI4K-BETA \| PI4KIIIbeta \| PI4Kbeta \| PIK4CB \| pi4K92	phosphatidylinositol 4-kinase, catalytic, beta	-	HPRD	11526106 \|12244129 \|14607934

miRNA Targets ?

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-15/16/195/424/497	697	703	m8	hsa-miR-15a^brain	UAGCAGCACAUAAUGGUUUGUG
				hsa-miR-16^brain	UAGCAGCACGUAAAUAUUGGCG
				hsa-miR-15b^brain	UAGCAGCACAUCAUGGUUUACA
				hsa-miR-195^SZ	UAGCAGCACAGAAAUAUUGGC
				hsa-miR-424	CAGCAGCAAUUCAUGUUUUGAA
				hsa-miR-497	CAGCAGCACACUGUGGUUUGU
miR-183	45	51	m8	hsa-miR-183	UAUGGCACUGGUAGAAUUCACUG
miR-200bc/429	611	617	m8	hsa-miR-200b	UAAUACUGCCUGGUAAUGAUGAC
				hsa-miR-200c	UAAUACUGCCGGGUAAUGAUGG
				hsa-miR-429	UAAUACUGUCUGGUAAAACCGU
miR-30-5p	743	749	1A	hsa-miR-30a-5p	UGUAAACAUCCUCGACUGGAAG
				hsa-miR-30c^brain	UGUAAACAUCCUACACUCUCAGC
				hsa-miR-30d^SZ	UGUAAACAUCCCCGACUGGAAG
				hsa-miR-30b^SZ	UGUAAACAUCCUACACUCAGCU
				hsa-miR-30e-5p	UGUAAACAUCCUUGACUGGA
miR-421	50	56	m8	hsa-miR-421	GGCCUCAUUAAAUGUUUGUUG
miR-505	3645	3651	1A	hsa-miR-505	GUCAACACUUGCUGGUUUCCUC

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.