Gene Page: XRCC6

Summary
GeneID  2547
Symbol  XRCC6
Synonyms  CTC75|CTCBF|G22P1|KU70|ML8|TLAA
Description  X-ray repair complementing defective repair in Chinese hamster cells 6
See related  HGNC:4055|MIM:152690|Ensembl:ENSG00000196419|HPRD:01071|
Locus tag  CTA-216E10.7
Gene type  protein-coding
Map location  22q13.2-q13.31
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0143 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
ZFYVE280.910.85
CNTNAP10.910.86
GOT10.900.78
THY10.890.79
TMEM38A0.890.91
PRRT30.890.79
TUBG20.890.90
DHRS110.890.83
AC105206.10.880.75
FAIM20.880.84
Top 10 negatively co-expressed genes
FADS2-0.59-0.65
TUBB2B-0.58-0.74
KIAA1949-0.58-0.65
TRAF4-0.56-0.72
SH3BP2-0.56-0.70
BCL7C-0.55-0.70
RBMX2-0.55-0.73
DYNLT1-0.55-0.76
YBX1-0.55-0.66
ZNF311-0.54-0.58
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003677DNA bindingNAS1537839 
GO:0003690double-stranded DNA bindingTAS7957065 
GO:0004003ATP-dependent DNA helicase activityTAS7957065 
GO:0008022protein C-terminus bindingIPI10783163 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006303double-strand break repair via nonhomologous end joiningTAS10508516 
GO:0006266DNA ligationTAS9826654 
GO:0019047provirus integrationEXP16291214 
GO:0019059initiation of viral infectionEXP12091904 
GO:0045893positive regulation of transcription, DNA-dependentIDA12145306 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005624membrane fractionTAS2917966 
GO:0005634nucleusTAS10508516 
GO:0005654nucleoplasmEXP12023295 |12065431 
GO:0005667transcription factor complexIDA12145306 
GO:0005737cytoplasmIEA-
GO:0005958DNA-dependent protein kinase complexIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
Two-hybridBioGRID10219089 
ABCD4ABC41 | EST352188 | P70R | P79R | PMP69 | PXMP1LATP-binding cassette, sub-family D (ALD), member 4Two-hybridBioGRID16169070 
ABL1ABL | JTK7 | bcr/abl | c-ABL | p150 | v-ablc-abl oncogene 1, receptor tyrosine kinase-HPRD,BioGRID9798959 
ACDPIP1 | PTOP | TINT1 | TPP1adrenocortical dysplasia homolog (mouse)Two-hybridBioGRID16169070 
APEX1APE | APE-1 | APE1 | APEN | APEX | APX | HAP1 | REF-1 | REF1APEX nuclease (multifunctional DNA repair enzyme) 1-HPRD8621488 
ARAIS | DHTR | HUMARA | KD | NR3C4 | SBMA | SMAX1 | TFMandrogen receptorAffinity Capture-WesternBioGRID15640154 
ARAP1CENTD2 | KIAA0782ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1Two-hybridBioGRID16169070 
ATP6V1E1ATP6E | ATP6E2 | ATP6V1E | P31 | Vma4ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1Two-hybridBioGRID16169070 
BARD1-BRCA1 associated RING domain 1BARD1 interacts with XRCC6 (Ku70).BIND15782130 
BIN1AMPH2 | AMPHL | DKFZp547F068 | MGC10367 | SH3P9bridging integrator 1Co-purificationBioGRID17671430 
C9orf46AD025 | FLJ14688 | FLJ39176 | MDS030chromosome 9 open reading frame 46Two-hybridBioGRID16169070 
CBX5HP1 | HP1Achromobox homolog 5 (HP1 alpha homolog, Drosophila)Ku70 interacts with HP1-alpha.BIND11112778 
-HPRD,BioGRID11112778 
CCNA1-cyclin A1cyclin A1 interacts with Ku70.BIND15159402 
Two-hybridBioGRID15159402 
CD40Bp50 | CDW40 | MGC9013 | TNFRSF5 | p50CD40 molecule, TNF receptor superfamily member 5-HPRD,BioGRID10514012 
CDCA5MGC16386 | SORORINcell division cycle associated 5Two-hybridBioGRID16169070 
CDK2p33(CDK2)cyclin-dependent kinase 2Biochemical ActivityBioGRID15159402 
CHEK1CHK1CHK1 checkpoint homolog (S. pombe)-HPRD,BioGRID12756247 
CLUAAG4 | APOJ | CLI | KUB1 | MGC24903 | SGP-2 | SGP2 | SP-40 | TRPM-2 | TRPM2clusterin-HPRD,BioGRID10219089 
CLU interacts with G22P1 (Ku70).BIND12551933 
CREBBPCBP | KAT3A | RSTSCREB binding proteinReconstituted Complex
Two-hybrid
BioGRID9488450 
DLX2TES-1 | TES1distal-less homeobox 2Reconstituted ComplexBioGRID11279128 
DNTTTDTdeoxynucleotidyltransferase, terminal-HPRD,BioGRID10570175 
EGFRERBB | ERBB1 | HER1 | PIG61 | mENAepidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)-HPRD9430697 
FMNL1C17orf1 | C17orf1B | FHOD4 | FMNL | KW-13 | MGC133052 | MGC1894 | MGC21878formin-like 1Two-hybridBioGRID16169070 
GAL3ST4FLJ12116 | GAL3ST-4galactose-3-O-sulfotransferase 4Two-hybridBioGRID16169070 
HOXC4HOX3 | HOX3E | cp19homeobox C4-HPRD,BioGRID11279128 
HOXD4HHO.C13 | HOX-5.1 | HOX4 | HOX4B | Hox-4.2homeobox D4Reconstituted ComplexBioGRID11279128 
HSF1HSTF1heat shock transcription factor 1-HPRD,BioGRID11162511 
ILVBL209L8 | AHAS | FLJ39061 | ILV2H | MGC1269 | MGC19535ilvB (bacterial acetolactate synthase)-likeTwo-hybridBioGRID16169070 
KAT2AGCN5 | GCN5L2 | MGC102791 | PCAF-b | hGCN5K(lysine) acetyltransferase 2A-HPRD,BioGRID9488450 
KIAA0182GSE1KIAA0182Two-hybridBioGRID16169070 
MAPK8JNK | JNK1 | JNK1A2 | JNK21B1/2 | PRKM8 | SAPK1mitogen-activated protein kinase 8-HPRD11749722 
MRE11AATLD | HNGS1 | MRE11 | MRE11BMRE11 meiotic recombination 11 homolog A (S. cerevisiae)-HPRD,BioGRID10508516 
NCF4MGC3810 | NCF | P40PHOX | SH3PXD4neutrophil cytosolic factor 4, 40kDa-HPRD,BioGRID9914162 
NCOA6AIB3 | ANTP | ASC2 | HOX1.1 | HOXA7 | KIAA0181 | NRC | PRIP | RAP250 | TRBPnuclear receptor coactivator 6Affinity Capture-MS
Reconstituted Complex
BioGRID10823961 |12519782 
NHP2L115.5K | FA-1 | FA1 | NHPX | OTK27 | SNU13 | SPAG12 | SSFA1NHP2 non-histone chromosome protein 2-like 1 (S. cerevisiae)Two-hybridBioGRID16169070 
NIT1MGC57670nitrilase 1Two-hybridBioGRID16169070 
NOTCH1TAN1 | hN1Notch homolog 1, translocation-associated (Drosophila)Two-hybridBioGRID16169070 
PAEPGD | GdA | GdF | GdS | MGC138509 | MGC142288 | PAEG | PEP | PP14progestagen-associated endometrial proteinTwo-hybridBioGRID16169070 
PAFAH1B3-platelet-activating factor acetylhydrolase, isoform Ib, gamma subunit 29kDaTwo-hybridBioGRID16169070 
PCNAMGC8367proliferating cell nuclear antigen-HPRD,BioGRID11239001 |12171929 
PECAM1CD31 | PECAM-1platelet/endothelial cell adhesion moleculeTwo-hybridBioGRID16169070 
PGAM1PGAM-B | PGAMAphosphoglycerate mutase 1 (brain)Two-hybridBioGRID16169070 
POU2F1OCT1 | OTF1POU class 2 homeobox 1Affinity Capture-WesternBioGRID11279128 
-HPRD12672812 
POU2F2OCT2 | OTF2 | Oct-2POU class 2 homeobox 2Reconstituted Complex
Two-hybrid
BioGRID11279128 
PRKDCDNA-PKcs | DNAPK | DNPK1 | HYRC | HYRC1 | XRCC7 | p350protein kinase, DNA-activated, catalytic polypeptide-HPRD9312071 |10446239 
|11279128 
Affinity Capture-Western
in vitro
in vivo
BioGRID10064605 |10446239 
PTTG1EAP1 | HPTTG | MGC126883 | MGC138276 | PTTG | TUTR1pituitary tumor-transforming 1-HPRD,BioGRID11238996 
RBBP4NURF55 | RBAP48retinoblastoma binding protein 4Two-hybridBioGRID16169070 
RPA2REPA2 | RPA32replication protein A2, 32kDaAffinity Capture-WesternBioGRID10064605 
RPLP1FLJ27448 | MGC5215 | P1 | RPP1ribosomal protein, large, P1Two-hybridBioGRID16169070 
RRAS2TC21related RAS viral (r-ras) oncogene homolog 2Two-hybridBioGRID16169070 
SERPINB9CAP-3 | CAP3 | PI9serpin peptidase inhibitor, clade B (ovalbumin), member 9Two-hybridBioGRID16169070 
SNTA1SNT1 | TACIP1 | dJ1187J4.5syntrophin, alpha 1 (dystrophin-associated protein A1, 59kDa, acidic component)Two-hybridBioGRID16169070 
TAL1SCL | TCL5 | bHLHa17 | tal-1T-cell acute lymphocytic leukemia 1Affinity Capture-MSBioGRID16407974 
TBCDKIAA0988tubulin folding cofactor DTwo-hybridBioGRID16169070 
TERF2TRBF2 | TRF2telomeric repeat binding factor 2-HPRD,BioGRID10984620 |11112778 
TERF2IPDRIP5 | RAP1telomeric repeat binding factor 2, interacting proteinAffinity Capture-MSBioGRID15100233 
TERTEST2 | TCS1 | TP2 | TRT | hEST2telomerase reverse transcriptase-HPRD,BioGRID12377759 
TP53FLJ92943 | LFS1 | TRP53 | p53tumor protein p53TP53 (p53) interacts with XRCC6 (Ku70).BIND15782130 
VAV1VAVvav 1 guanine nucleotide exchange factor-HPRD,BioGRID8524317 
WRNDKFZp686C2056 | RECQ3 | RECQL2 | RECQL3Werner syndromeWRN interacts with G22P1 (Ku70) as part of a complex.BIND14734561 
-HPRD,BioGRID12177300 
XRCC5FLJ39089 | KARP-1 | KARP1 | KU80 | KUB2 | Ku86 | NFIVX-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)Affinity Capture-Western
Co-fractionation
in vitro
in vivo
Reconstituted Complex
Two-hybrid
BioGRID9488450 |10207052 
|10219089 |10446239 
|10984620 
Ku70 interacts with Ku80BIND11493912 
-HPRD10207052 |10446239 
XRCC6BP1KUB3 | MGC134817 | MGC134818XRCC6 binding protein 1-HPRD,BioGRID10219089 
YWHAZKCIP-1 | MGC111427 | MGC126532 | MGC138156tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptideTwo-hybridBioGRID16169070 
 


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