Gene Page: ZNF324
Summary ?
| GeneID | 25799 |
| Symbol | ZNF324 |
| Synonyms | ZF5128|ZNF324A |
| Description | zinc finger protein 324 |
| Reference | HGNC:HGNC:14096|Ensembl:ENSG00000083812|HPRD:11708|Vega:OTTHUMG00000183540 |
| Gene type | protein-coding |
| Map location | 19q13.43 |
| Pascal p-value | 0.063 |
| Sherlock p-value | 0.342 |
| Fetal beta | 0.225 |
| DMG | 1 (# studies) |
| eGene | Myers' cis & trans |
| Support | Ascano FMRP targets |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DMG:Wockner_2014 | Genome-wide DNA methylation analysis | This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). | 1 |
Section I. Genetics and epigenetics annotation
Differentially methylated gene
| Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
|---|---|---|---|---|---|---|---|
| cg07100957 | 19 | 58982330 | ZNF324 | 2.58E-5 | 0.406 | 0.017 | DMG:Wockner_2014 |
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs2009141 | chr4 | 173756532 | ZNF324 | 25799 | 0.07 | trans |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| ARHGAP20 | 0.86 | 0.92 |
| DOCK9 | 0.85 | 0.88 |
| AC093307.1 | 0.85 | 0.90 |
| FLRT2 | 0.84 | 0.90 |
| NAV3 | 0.84 | 0.86 |
| MKL1 | 0.83 | 0.86 |
| KIF3C | 0.83 | 0.86 |
| MAPKBP1 | 0.83 | 0.86 |
| RBM24 | 0.83 | 0.90 |
| CHN2 | 0.83 | 0.87 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| MT-CO2 | -0.66 | -0.70 |
| AF347015.31 | -0.65 | -0.69 |
| FXYD1 | -0.65 | -0.66 |
| HSD17B14 | -0.64 | -0.68 |
| BDH2 | -0.64 | -0.68 |
| SERPINB6 | -0.64 | -0.68 |
| HIGD1B | -0.63 | -0.69 |
| C11orf67 | -0.63 | -0.68 |
| ACSF2 | -0.63 | -0.69 |
| MT-CYB | -0.63 | -0.65 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| REACTOME GENERIC TRANSCRIPTION PATHWAY | 352 | 181 | All SZGR 2.0 genes in this pathway |
| ROVERSI GLIOMA COPY NUMBER UP | 100 | 75 | All SZGR 2.0 genes in this pathway |
| MARTENS TRETINOIN RESPONSE DN | 841 | 431 | All SZGR 2.0 genes in this pathway |