Gene Page: FBXO5

Summary
GeneID  26271
Symbol  FBXO5
Synonyms  EMI1|FBX5|Fbxo31
Description  F-box protein 5
See related  HGNC:13584|MIM:606013|Ensembl:ENSG00000112029|HPRD:09348|
Locus tag  -
Gene type  protein-coding
Map location  6q25-q26
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
PLAGL20.920.88
ZFYVE260.920.92
PHF80.920.93
KIAA13100.910.92
ABL10.910.90
BAZ2A0.910.94
CCND20.910.90
MAML10.910.89
GCN1L10.910.89
EP4000.910.92
Top 10 negatively co-expressed genes
AF347015.31-0.61-0.75
AF347015.21-0.60-0.82
MT-CO2-0.60-0.74
IFI27-0.59-0.72
FXYD1-0.58-0.71
AF347015.27-0.58-0.70
HIGD1B-0.58-0.73
AF347015.8-0.57-0.70
C1orf54-0.56-0.80
S100A16-0.56-0.69
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005515protein bindingIPI11988738 |12791267 
GO:0008270zinc ion bindingIEA-
GO:0046872metal ion bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0000089mitotic metaphaseIEA-
GO:0001556oocyte maturationIEA-
GO:0006511ubiquitin-dependent protein catabolic processIEA-
GO:0016050vesicle organizationIEA-
GO:0007346regulation of mitotic cell cycleIEA-
GO:0007346regulation of mitotic cell cycleISS-
GO:0007049cell cycleIEA-
GO:0007057spindle assembly involved in female meiosis IIEA-
GO:0007067mitosisIEA-
GO:0007128meiotic prophase IIEA-
GO:0051225spindle assemblyIEA-
GO:0051301cell divisionIEA-
GO:0040020regulation of meiosisIEA-
GO:0046785microtubule polymerizationIEA-
GO:0051436negative regulation of ubiquitin-protein ligase activity during mitotic cell cycleIDA11988738 |16921029 
GO:0051437positive regulation of ubiquitin-protein ligase activity during mitotic cell cycleEXP12791267 
GO:0051442negative regulation of ubiquitin-protein ligase activity during meiotic cell cycleIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005819spindleIDA15469984 
GO:0005829cytosolEXP15469984 
GO:0005634nucleusIDA11988738 
GO:0005654nucleoplasmEXP11988738 |12791267 |15148369 
|15469984 
GO:0005737cytoplasmIDA11988738 
GO:0005737cytoplasmIEA-
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CDC20CDC20A | MGC102824 | bA276H19.3 | p55CDCcell division cycle 20 homolog (S. cerevisiae)-HPRD,BioGRID11389834 |11976684 
|11988738 
FZR1CDC20C | CDH1 | FZR | FZR2 | HCDH | HCDH1 | KIAA1242fizzy/cell division cycle 20 related 1 (Drosophila)-HPRD,BioGRID11988738 
SKP1EMC19 | MGC34403 | OCP-II | OCP2 | SKP1A | TCEB1L | p19AS-phase kinase-associated protein 1Reconstituted Complex
Two-hybrid		BioGRID10531035 
Skp1 interacts with Fbx5.BIND10531035 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_OOCYTE_MEIOSIS 11479All SZGR genes in this pathway
PID_PLK1_PATHWAY 4625All SZGR genes in this pathway
REACTOME_CELL_CYCLE 421253All SZGR genes in this pathway
REACTOME_CELL_CYCLE_MITOTIC 325185All SZGR genes in this pathway
REACTOME_G1_S_TRANSITION 11263All SZGR genes in this pathway
REACTOME_MITOTIC_G1_G1_S_PHASES 13779All SZGR genes in this pathway
REACTOME_REGULATION_OF_MITOTIC_CELL_CYCLE 8546All SZGR genes in this pathway
REACTOME_MITOTIC_M_M_G1_PHASES 17298All SZGR genes in this pathway
REACTOME_DNA_REPLICATION 192110All SZGR genes in this pathway
REACTOME_E2F_MEDIATED_REGULATION_OF_DNA_REPLICATION 3517All SZGR genes in this pathway
REACTOME_SCF_BETA_TRCP_MEDIATED_DEGRADATION_OF_EMI1 5132All SZGR genes in this pathway
REACTOME_G1_S_SPECIFIC_TRANSCRIPTION 199All SZGR genes in this pathway
SOTIRIOU_BREAST_CANCER_GRADE_1_VS_3_UP 15184All SZGR genes in this pathway
GARY_CD5_TARGETS_DN 431263All SZGR genes in this pathway
ODONNELL_TFRC_TARGETS_DN 13976All SZGR genes in this pathway
TIEN_INTESTINE_PROBIOTICS_24HR_UP 557331All SZGR genes in this pathway
KINSEY_TARGETS_OF_EWSR1_FLII_FUSION_UP 1278748All SZGR genes in this pathway
SCIBETTA_KDM5B_TARGETS_DN 8155All SZGR genes in this pathway
GRAHAM_CML_DIVIDING_VS_NORMAL_QUIESCENT_UP 181101All SZGR genes in this pathway
DODD_NASOPHARYNGEAL_CARCINOMA_DN 1375806All SZGR genes in this pathway
RODRIGUES_THYROID_CARCINOMA_POORLY_DIFFERENTIATED_UP 633376All SZGR genes in this pathway
TANG_SENESCENCE_TP53_TARGETS_DN 5733All SZGR genes in this pathway
KAN_RESPONSE_TO_ARSENIC_TRIOXIDE 12380All SZGR genes in this pathway
ROSTY_CERVICAL_CANCER_PROLIFERATION_CLUSTER 14073All SZGR genes in this pathway
HERNANDEZ_MITOTIC_ARREST_BY_DOCETAXEL_1_DN 3823All SZGR genes in this pathway
NUYTTEN_NIPP1_TARGETS_DN 848527All SZGR genes in this pathway
BUYTAERT_PHOTODYNAMIC_THERAPY_STRESS_DN 637377All SZGR genes in this pathway
BENPORATH_MYC_MAX_TARGETS 775494All SZGR genes in this pathway
GEORGES_TARGETS_OF_MIR192_AND_MIR215 893528All SZGR genes in this pathway
STEGMEIER_PRE-MITOTIC_CELL_CYCLE_REGULATORS 118All SZGR genes in this pathway
SHEPARD_BMYB_MORPHOLINO_DN 200112All SZGR genes in this pathway
SHEPARD_BMYB_TARGETS 7441All SZGR genes in this pathway
SHEPARD_CRUSH_AND_BURN_MUTANT_DN 185111All SZGR genes in this pathway
MANALO_HYPOXIA_DN 289166All SZGR genes in this pathway
VANTVEER_BREAST_CANCER_METASTASIS_DN 12165All SZGR genes in this pathway
VERNELL_RETINOBLASTOMA_PATHWAY_UP 7047All SZGR genes in this pathway
MARSON_BOUND_BY_E2F4_UNSTIMULATED 728415All SZGR genes in this pathway
SARRIO_EPITHELIAL_MESENCHYMAL_TRANSITION_UP 180114All SZGR genes in this pathway
FUJII_YBX1_TARGETS_DN 202132All SZGR genes in this pathway
MITSIADES_RESPONSE_TO_APLIDIN_DN 249165All SZGR genes in this pathway
BLUM_RESPONSE_TO_SALIRASIB_DN 342220All SZGR genes in this pathway
SHEDDEN_LUNG_CANCER_POOR_SURVIVAL_A6 456285All SZGR genes in this pathway
COLINA_TARGETS_OF_4EBP1_AND_4EBP2 356214All SZGR genes in this pathway
CHIANG_LIVER_CANCER_SUBCLASS_PROLIFERATION_UP 178108All SZGR genes in this pathway
SAKAI_CHRONIC_HEPATITIS_VS_LIVER_CANCER_UP 8363All SZGR genes in this pathway
CAIRO_HEPATOBLASTOMA_CLASSES_UP 605377All SZGR genes in this pathway
DANG_BOUND_BY_MYC 1103714All SZGR genes in this pathway
MARTENS_TRETINOIN_RESPONSE_DN 841431All SZGR genes in this pathway
DUTERTRE_ESTRADIOL_RESPONSE_24HR_UP 324193All SZGR genes in this pathway
JOHNSTONE_PARVB_TARGETS_3_DN 918550All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_EARLY_LATE 317190All SZGR genes in this pathway
FEVR_CTNNB1_TARGETS_DN 553343All SZGR genes in this pathway
GOBERT_OLIGODENDROCYTE_DIFFERENTIATION_UP 570339All SZGR genes in this pathway
REICHERT_MITOSIS_LIN9_TARGETS 2817All SZGR genes in this pathway
ZHOU_CELL_CYCLE_GENES_IN_IR_RESPONSE_6HR 8549All SZGR genes in this pathway
ZHOU_CELL_CYCLE_GENES_IN_IR_RESPONSE_24HR 12873All SZGR genes in this pathway


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