Gene Page: FBXO5

Summary ?
GeneID26271
SymbolFBXO5
SynonymsEMI1|FBX5|Fbxo31
DescriptionF-box protein 5
ReferenceMIM:606013|HGNC:HGNC:13584|Ensembl:ENSG00000112029|HPRD:09348|Vega:OTTHUMG00000015854
Gene typeprotein-coding
Map location6q25.2
Pascal p-value0.161
Sherlock p-value0.529

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:GWASdbGenome-wide Association StudiesGWASdb records for schizophrenia
CV:PGCnpGenome-wide Association StudyGWAS

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
PLAGL20.920.88
ZFYVE260.920.92
PHF80.920.93
KIAA13100.910.92
ABL10.910.90
BAZ2A0.910.94
CCND20.910.90
MAML10.910.89
GCN1L10.910.89
EP4000.910.92
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
AF347015.31-0.61-0.75
AF347015.21-0.60-0.82
MT-CO2-0.60-0.74
IFI27-0.59-0.72
FXYD1-0.58-0.71
AF347015.27-0.58-0.70
HIGD1B-0.58-0.73
AF347015.8-0.57-0.70
C1orf54-0.56-0.80
S100A16-0.56-0.69

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005515protein bindingIPI11988738 |12791267 
GO:0008270zinc ion bindingIEA-
GO:0046872metal ion bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0000089mitotic metaphaseIEA-
GO:0001556oocyte maturationIEA-
GO:0006511ubiquitin-dependent protein catabolic processIEA-
GO:0016050vesicle organizationIEA-
GO:0007346regulation of mitotic cell cycleIEA-
GO:0007346regulation of mitotic cell cycleISS-
GO:0007049cell cycleIEA-
GO:0007057spindle assembly involved in female meiosis IIEA-
GO:0007067mitosisIEA-
GO:0007128meiotic prophase IIEA-
GO:0051225spindle assemblyIEA-
GO:0051301cell divisionIEA-
GO:0040020regulation of meiosisIEA-
GO:0046785microtubule polymerizationIEA-
GO:0051436negative regulation of ubiquitin-protein ligase activity during mitotic cell cycleIDA11988738 |16921029 
GO:0051437positive regulation of ubiquitin-protein ligase activity during mitotic cell cycleEXP12791267 
GO:0051442negative regulation of ubiquitin-protein ligase activity during meiotic cell cycleIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005819spindleIDA15469984 
GO:0005829cytosolEXP15469984 
GO:0005634nucleusIDA11988738 
GO:0005654nucleoplasmEXP11988738 |12791267 |15148369 
|15469984 
GO:0005737cytoplasmIDA11988738 
GO:0005737cytoplasmIEA-

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG OOCYTE MEIOSIS 11479All SZGR 2.0 genes in this pathway
PID PLK1 PATHWAY 4625All SZGR 2.0 genes in this pathway
REACTOME CELL CYCLE 421253All SZGR 2.0 genes in this pathway
REACTOME CELL CYCLE MITOTIC 325185All SZGR 2.0 genes in this pathway
REACTOME G1 S TRANSITION 11263All SZGR 2.0 genes in this pathway
REACTOME MITOTIC G1 G1 S PHASES 13779All SZGR 2.0 genes in this pathway
REACTOME REGULATION OF MITOTIC CELL CYCLE 8546All SZGR 2.0 genes in this pathway
REACTOME MITOTIC M M G1 PHASES 17298All SZGR 2.0 genes in this pathway
REACTOME DNA REPLICATION 192110All SZGR 2.0 genes in this pathway
REACTOME E2F MEDIATED REGULATION OF DNA REPLICATION 3517All SZGR 2.0 genes in this pathway
REACTOME SCF BETA TRCP MEDIATED DEGRADATION OF EMI1 5132All SZGR 2.0 genes in this pathway
REACTOME G1 S SPECIFIC TRANSCRIPTION 199All SZGR 2.0 genes in this pathway
SOTIRIOU BREAST CANCER GRADE 1 VS 3 UP 15184All SZGR 2.0 genes in this pathway
GARY CD5 TARGETS DN 431263All SZGR 2.0 genes in this pathway
ODONNELL TFRC TARGETS DN 13976All SZGR 2.0 genes in this pathway
TIEN INTESTINE PROBIOTICS 24HR UP 557331All SZGR 2.0 genes in this pathway
KINSEY TARGETS OF EWSR1 FLII FUSION UP 1278748All SZGR 2.0 genes in this pathway
SCIBETTA KDM5B TARGETS DN 8155All SZGR 2.0 genes in this pathway
GRAHAM CML DIVIDING VS NORMAL QUIESCENT UP 181101All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA DN 1375806All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA POORLY DIFFERENTIATED UP 633376All SZGR 2.0 genes in this pathway
TANG SENESCENCE TP53 TARGETS DN 5733All SZGR 2.0 genes in this pathway
KAN RESPONSE TO ARSENIC TRIOXIDE 12380All SZGR 2.0 genes in this pathway
ROSTY CERVICAL CANCER PROLIFERATION CLUSTER 14073All SZGR 2.0 genes in this pathway
HERNANDEZ MITOTIC ARREST BY DOCETAXEL 1 DN 3823All SZGR 2.0 genes in this pathway
NUYTTEN NIPP1 TARGETS DN 848527All SZGR 2.0 genes in this pathway
BUYTAERT PHOTODYNAMIC THERAPY STRESS DN 637377All SZGR 2.0 genes in this pathway
BENPORATH MYC MAX TARGETS 775494All SZGR 2.0 genes in this pathway
GEORGES TARGETS OF MIR192 AND MIR215 893528All SZGR 2.0 genes in this pathway
STEGMEIER PRE-MITOTIC CELL CYCLE REGULATORS 118All SZGR 2.0 genes in this pathway
SHEPARD BMYB MORPHOLINO DN 200112All SZGR 2.0 genes in this pathway
SHEPARD BMYB TARGETS 7441All SZGR 2.0 genes in this pathway
SHEPARD CRUSH AND BURN MUTANT DN 185111All SZGR 2.0 genes in this pathway
MANALO HYPOXIA DN 289166All SZGR 2.0 genes in this pathway
VANTVEER BREAST CANCER METASTASIS DN 12165All SZGR 2.0 genes in this pathway
VERNELL RETINOBLASTOMA PATHWAY UP 7047All SZGR 2.0 genes in this pathway
MARSON BOUND BY E2F4 UNSTIMULATED 728415All SZGR 2.0 genes in this pathway
SARRIO EPITHELIAL MESENCHYMAL TRANSITION UP 180114All SZGR 2.0 genes in this pathway
FUJII YBX1 TARGETS DN 202132All SZGR 2.0 genes in this pathway
MITSIADES RESPONSE TO APLIDIN DN 249165All SZGR 2.0 genes in this pathway
BLUM RESPONSE TO SALIRASIB DN 342220All SZGR 2.0 genes in this pathway
SHEDDEN LUNG CANCER POOR SURVIVAL A6 456285All SZGR 2.0 genes in this pathway
COLINA TARGETS OF 4EBP1 AND 4EBP2 356214All SZGR 2.0 genes in this pathway
CHIANG LIVER CANCER SUBCLASS PROLIFERATION UP 178108All SZGR 2.0 genes in this pathway
SAKAI CHRONIC HEPATITIS VS LIVER CANCER UP 8363All SZGR 2.0 genes in this pathway
CAIRO HEPATOBLASTOMA CLASSES UP 605377All SZGR 2.0 genes in this pathway
DANG BOUND BY MYC 1103714All SZGR 2.0 genes in this pathway
MARTENS TRETINOIN RESPONSE DN 841431All SZGR 2.0 genes in this pathway
DUTERTRE ESTRADIOL RESPONSE 24HR UP 324193All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 3 DN 918550All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE EARLY LATE 317190All SZGR 2.0 genes in this pathway
FEVR CTNNB1 TARGETS DN 553343All SZGR 2.0 genes in this pathway
GOBERT OLIGODENDROCYTE DIFFERENTIATION UP 570339All SZGR 2.0 genes in this pathway
REICHERT MITOSIS LIN9 TARGETS 2817All SZGR 2.0 genes in this pathway
ZHOU CELL CYCLE GENES IN IR RESPONSE 6HR 8549All SZGR 2.0 genes in this pathway
ZHOU CELL CYCLE GENES IN IR RESPONSE 24HR 12873All SZGR 2.0 genes in this pathway