Gene Page: GJA8
Summary ?
| GeneID | 2703 |
| Symbol | GJA8 |
| Synonyms | CAE|CAE1|CTRCT1|CX50|CZP1|MP70 |
| Description | gap junction protein alpha 8 |
| Reference | MIM:600897|HGNC:HGNC:4281|HPRD:02939| |
| Gene type | protein-coding |
| Map location | 1q21.1 |
| Fetal beta | -0.408 |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CNV:YES | Copy number variation studies | Manual curation | |
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| PMID:cooccur | High-throughput literature-search | Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included. | |
| Association | A combined odds ratio method (Sun et al. 2008), association studies | 2 | Link to SZGene |
| GSMA_I | Genome scan meta-analysis | Psr: 0.0235 | |
| GSMA_IIA | Genome scan meta-analysis (All samples) | Psr: 0.00814 | |
| Literature | High-throughput literature-search | Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias | Click to show details |
Section I. Genetics and epigenetics annotation
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| SNX31 | 0.68 | 0.35 |
| ZMYND10 | 0.66 | 0.46 |
| ANXA1 | 0.65 | 0.38 |
| GLB1L | 0.65 | 0.43 |
| C13orf26 | 0.65 | 0.41 |
| C11orf70 | 0.64 | 0.27 |
| C2orf39 | 0.64 | 0.39 |
| C19orf51 | 0.64 | 0.37 |
| C2orf70 | 0.64 | 0.33 |
| EFCAB1 | 0.64 | 0.49 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| S100A1 | -0.25 | -0.12 |
| AF347015.2 | -0.21 | -0.21 |
| ALDH1A1 | -0.21 | -0.07 |
| SEPT4 | -0.20 | -0.15 |
| AF347015.33 | -0.20 | -0.18 |
| HPSE2 | -0.20 | -0.12 |
| CD8BP | -0.20 | -0.12 |
| TNFSF13 | -0.19 | -0.10 |
| KIF1C | -0.19 | -0.09 |
| MT1G | -0.19 | -0.10 |
Section III. Gene Ontology annotation
| Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0015267 | channel activity | TAS | 7796604 | |
| Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0007154 | cell communication | IEA | - | |
| GO:0007601 | visual perception | TAS | 9497259 | |
| GO:0006810 | transport | TAS | 7796604 | |
| GO:0043010 | camera-type eye development | IEA | - | |
| Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0005922 | connexon complex | TAS | 9497259 | |
| GO:0005886 | plasma membrane | IEA | - | |
| GO:0005887 | integral to plasma membrane | TAS | 7796604 | |
| GO:0030054 | cell junction | IEA | - |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| REACTOME MEMBRANE TRAFFICKING | 129 | 74 | All SZGR 2.0 genes in this pathway |
| REACTOME GAP JUNCTION TRAFFICKING | 27 | 19 | All SZGR 2.0 genes in this pathway |
| REACTOME GAP JUNCTION ASSEMBLY | 18 | 12 | All SZGR 2.0 genes in this pathway |
| PUJANA ATM PCC NETWORK | 1442 | 892 | All SZGR 2.0 genes in this pathway |
| SHEN SMARCA2 TARGETS DN | 357 | 212 | All SZGR 2.0 genes in this pathway |
| ZWANG TRANSIENTLY UP BY 2ND EGF PULSE ONLY | 1725 | 838 | All SZGR 2.0 genes in this pathway |